Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies

scientific article published on 03 May 2007

Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1041920572
P356DOI10.1038/SJ.LEU.2404709
P698PubMed publication ID17476281

P50authorMarcos González DíazQ5996580
Josep NomdedeuQ50238034
Mar TormoQ53101846
Maria José TerolQ55445053
M J CalasanzQ67566883
Ana LluchQ67755317
Vicente Martin GuillemQ73275907
P2093author name stringBolufer P
Collado M
Esteve J
Sanzo C
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Score tests for association between traits and haplotypes when linkage phase is ambiguousQ29616281
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistanceQ29616511
Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemiaQ32073276
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia.Q33944747
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.Q34025724
The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemiaQ34155718
Genetic predisposition and treatment-related leukemiaQ34243517
The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and functionQ34290755
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?Q34385362
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.Q35080478
5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireviewQ35097747
Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivationQ35792429
Therapy-related leukemia and myelodysplasia: evolving concepts of pathogenesis and treatmentQ35809447
Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemiaQ36600942
Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neckQ38318875
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexateQ40597353
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivityQ42808297
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteineQ43631868
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease riskQ43787664
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemiaQ43963806
Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexateQ44230880
Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis.Q44298677
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.Q45193940
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivityQ45285628
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemiaQ46410865
MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer StudyQ46469731
MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemiaQ46819261
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.Q46931731
XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects.Q53396019
SNPStats: a web tool for the analysis of association studies.Q53731244
Genotype of glutathione S-transferase and other genetic configurations in myelodysplasiaQ73215627
Therapy related acute myeloid leukemia after exposure to 5-fluorouracil: a case reportQ73393250
Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignanciesQ73446152
P433issue7
P304page(s)1413-1422
P577publication date2007-05-03
P1433published inLeukemiaQ6534498
P1476titleRole of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies
P478volume21

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cites work (P2860)
Q34450001A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk
Q37855227An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Q35106332Association between MTHFR polymorphisms and acute myeloid leukemia risk: a meta-analysis
Q38861651Associations of NQO1 C609T and NQO1 C465T polymorphisms with acute leukemia risk: a PRISMA-compliant meta-analysis.
Q38403345Comprehensive assessment of the association between DNA repair gene XRCC3 Thr241Met polymorphism and leukemia risk
Q33606720Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects
Q35117677Genetic variation as a modifier of association between therapeutic exposure and subsequent malignant neoplasms in cancer survivors
Q38063197Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia
Q60907615Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms
Q34411659Polymorphisms in XPC provide prognostic information in acute myeloid leukemia
Q36605135Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia
Q57127326Problems to affect long-term survival for breast cancer patients: An observational study of subsequent lung/bronchus malignancies
Q52653738Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.
Q37009760Therapy-related myeloid leukemia.
Q38039381What's all the fuss about? facts and figures about bone marrow failure and conditions

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