Engineering predictability and protraction in a basal insulin analogue: the pharmacology of insulin detemir

scientific article published on 01 September 2004

Engineering predictability and protraction in a basal insulin analogue: the pharmacology of insulin detemir is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.IJO.0802746
P698PubMed publication ID15306834

P2093author name stringP Kurtzhals
P2860cites workCrystal structure of a prolonged-acting insulin with albumin-binding propertiesQ27734944
Insulin analogs with improved pharmacokinetic profilesQ33933381
Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cellQ34275166
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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.Q34315974
Insulins today and beyondQ34365284
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Absorption of isophane (NPH) insulin and its clinical implications.Q34762491
Variability of insulin absorption and insulin actionQ35008637
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Insulin analogues and other developments in insulin therapy for diabetesQ35164710
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Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albuminQ41696877
Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivoQ41861199
Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potencyQ42177647
Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusionQ43901566
Albumin binding of acylated insulin (NN304) does not deter action to stimulate glucose uptakeQ43901624
A comparison of postprandial and preprandial administration of insulin aspart in children and adolescents with type 1 diabetesQ44526983
Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetesQ44909481
Pharmacokinetics of 125I-labeled insulin glargine (HOE 901) in healthy men: comparison with NPH insulin and the influence of different subcutaneous injection sites.Q55033955
The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human InsulinQ57599459
Monomeric insulins obtained by protein engineering and their medical implicationsQ59060531
The reality of glycaemic control in insulin treated diabetes: defining the clinical challengesQ59311929
Subcutaneous Insulin Absorption Explained by Insulin's Physicochemical Properties: Evidence From Absorption Studies of Soluble Human Insulin and Insulin Analogues in HumansQ67868378
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitusQ68134802
Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and crystallizability of insulins substituted in the termini of the B-chainQ68245775
Soluble, prolonged-acting insulin derivatives. II. Degree of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30Q68245778
Basal and 24-h C-peptide and insulin secretion rate in normal manQ68950608
Diffusion and polymerization determines the insulin absorption from subcutaneous tissue in diabetic patientsQ69923821
The cobalt(III)-insulin hexamer is a prolonged-acting insulin prodrugQ71520692
Action Profile of Cobalt(III)-Insulin: A Novel Principle of Protraction of Potential Use for Basal Insulin DeliveryQ71816863
Inadequate suspension of neutral protamine Hagendorn (NPH) insulin in pensQ73179764
Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humansQ73824586
Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placeboQ73840622
Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical useQ73922459
Effect of fatty acids and selected drugs on the albumin binding of a long-acting, acylated insulin analogueQ74017384
Insulin detemir: improving the predictability of glycaemic controlQ80442184
P921main subjectpharmacologyQ128406
insulin detemirQ410965
P304page(s)S23-8
P577publication date2004-09-01
P1476titleEngineering predictability and protraction in a basal insulin analogue: the pharmacology of insulin detemir
P478volume28 Suppl 2