TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis

scientific article published on 01 February 2008

TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.3061-07.2008
P932PMC publication ID6671436
P698PubMed publication ID18287512

P2093author name stringAzad Bonni
Mai Anh Huynh
Yoshiyuki Konishi
Zengqiang Yuan
Judith Stegmüller
P2860cites workDirect interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1Q21284174
Negative feedback regulation of TGF-beta signaling by the SnoN oncoproteinQ22010706
A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitorsQ24297856
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Q24299813
Sumoylated SnoN represses transcription in a promoter-specific mannerQ24302417
The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteinsQ24302423
Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoNQ24324676
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoNQ24600452
Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neuronsQ24670261
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradationQ28199064
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligaseQ28249846
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complexQ28249855
New insights into TGF-beta-Smad signallingQ28260517
SnoN is a cell type-specific mediator of transforming growth factor-beta responsesQ28304684
Bcl-2 promotes regeneration of severed axons in mammalian CNSQ28504892
Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cellsQ28573415
SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signalingQ28608960
The molecular biology of axon guidanceQ29617857
Molecular mechanisms of axon guidanceQ29620362
Smads as transcriptional co-modulatorsQ33860520
Ski/Sno and TGF-beta signaling.Q34225107
TGF-betas and their roles in the regulation of neuron survivalQ35063091
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.Q35209949
Transforming growth factor-beta and ischemic brain injuryQ35545534
Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegenerationQ35722374
Intrinsic neuronal regulation of axon and dendrite growth.Q35909227
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.Q36109451
Emerging roles for TGF-beta1 in nervous system developmentQ36152409
Moving past proliferation: new roles for Cdh1-APC in postmitotic neuronsQ36259807
A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered modelsQ36683235
Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous systemQ36708206
Transcriptional regulation of vertebrate axon guidance and synapse formationQ36799115
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.Q40261081
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cellsQ40602724
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destructionQ40763954
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cellsQ41877034
Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip.Q41928071
Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependentQ42483089
Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibitionQ42738100
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradationQ43832078
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machineryQ44017737
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome systemQ44485246
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.Q44772939
Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruningQ47071604
Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling.Q47343275
Smad6 inhibits signalling by the TGF-beta superfamilyQ48044158
Cdh1-APC controls axonal growth and patterning in the mammalian brainQ48096732
Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matterQ48105976
Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brainQ48110101
Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cordQ48584785
Myelination in rat brain: method of myelin isolationQ48629501
Genetic analyses demonstrate that bone morphogenetic protein signaling is required for embryonic cerebellar development.Q48648484
Localization of transforming growth factor-beta1 and receptor mRNA after experimental spinal cord injuryQ73721201
RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survivalQ74796123
P433issue8
P304page(s)1961-1969
P577publication date2008-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleTGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis
P478volume28

Reverse relations

cites work (P2860)
Q28570816A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain
Q28073361A decade of the anaphase-promoting complex in the nervous system
Q37799221APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity
Q91235044Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes
Q37375249Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity
Q34774782An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain
Q40002781An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons
Q36651360Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis
Q38188439Cell intrinsic control of axon regeneration
Q37985959Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling
Q37347653Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain.
Q34908635Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1
Q38825736Effect of cilostazol pretreatment on the PARP/AIF-mediated apoptotic pathway in rat cerebral ischemia-reperfusion models
Q36682829GDF10 is a signal for axonal sprouting and functional recovery after stroke.
Q42706732Genetic manipulation of cerebellar granule neurons in vitro and in vivo to study neuronal morphology and migration
Q34584292HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion
Q24310196ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells
Q34806677Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells
Q37746477Initiating and growing an axon.
Q35539750Multiple transcription factor families regulate axon growth and regeneration
Q55305045Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration.
Q36183127Neuronal polarity: demarcation, growth and commitment
Q37857958Novel functions for the anaphase-promoting complex in neurobiology.
Q39014622PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism
Q33737827Pathway bridge based multiobjective optimization approach for lurking pathway prediction
Q34612748Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction
Q36394421Regulation of APC/C-Cdh1 and its function in neuronal survival
Q33731826Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation
Q36934092Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2.
Q37359949Ski and SnoN, potent negative regulators of TGF-beta signaling
Q34998146Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice
Q34927127SnoN facilitates axonal regeneration after spinal cord injury
Q37498907SnoN in regulation of embryonic development and tissue morphogenesis
Q36058887SnoN signaling in proliferating cells and postmitotic neurons
Q41820973SnoN: bridging neurobiology and cancer biology
Q36756238Spatial organization of ubiquitin ligase pathways orchestrates neuronal connectivity.
Q61794334Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits A
Q36591813TGFβ signaling induces expression of Gadd45b in retinal ganglion cells
Q34139057TIF1γ protein regulates epithelial-mesenchymal transition by operating as a small ubiquitin-like modifier (SUMO) E3 ligase for the transcriptional regulator SnoN1.
Q40010489The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction
Q38711030The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling
Q93051854The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain
Q35055074The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity
Q37614211The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression
Q37865793The emerging role of APC/CCdh1 in development
Q36799312The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner
Q62060038Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
Q34222337Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain
Q30423475p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation

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