Suppression of viral replication with highly active antiretroviral therapy has no impact on the functional profile of HIV-specific CD8(+) T cells

scientific article published on 01 June 2008

Suppression of viral replication with highly active antiretroviral therapy has no impact on the functional profile of HIV-specific CD8(+) T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.200738054
P698PubMed publication ID18421792

P50authorVicente SorianoQ55277832
Norma I RallónQ80787266
P2093author name stringJosé M Benito
Juan González-Lahoz
Mariola López
Almudena Cascajero
P2860cites workVirus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infectionQ28304764
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferonQ33603919
HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.Q33772204
Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapyQ33843388
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cellsQ33981572
Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen loadQ35784804
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic functionQ35834664
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV developmentQ36600351
Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.Q36644746
Escape mutations in HIV infection and its impact on CD8+ T cell responsesQ36907342
Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infectionQ42261780
Phenotype and functional characteristics of HIV-specific cytotoxic CD8+ T cells in chronically infected patients: dual effects of highly active antiretroviral therapyQ43653991
Skewed maturation of memory HIV-specific CD8 T lymphocytesQ45284555
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsQ45733084
Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activityQ45787868
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alphaQ47835000
Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNAQ56930699
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytesQ57075675
Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDSQ77768092
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
P433issue6
P304page(s)1548-1558
P577publication date2008-06-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleSuppression of viral replication with highly active antiretroviral therapy has no impact on the functional profile of HIV-specific CD8(+) T cells
P478volume38

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cites work (P2860)
Q34730855CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy
Q37521828Effect of maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals
Q33952015Human immunodeficiency virus type I-specific CD8+ T cell subset abnormalities in chronic infection persist through effective antiretroviral therapy
Q35795271Initiation of Antiretroviral Therapy (ART) at Different Stages of HIV-1 Disease Is Not Associated with the Proportion of Exhausted CD8+ T Cells
Q39550595Interleukin-12p70 expression by dendritic cells of HIV-1-infected patients fails to stimulate gag-specific immune responses
Q35092923Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy
Q33381538Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status
Q82964253Polyfunctional analysis of Gag and Nef specific CD8+ T-cell responses in HIV-1 infected Indian individuals
Q37389999Reconstitution of Peripheral T Cells by Tissue-Derived CCR4+ Central Memory Cells Following HIV-1 Antiretroviral Therapy
Q27025707The enduring tale of T cells in HIV immunopathogenesis
Q85052418The expansion ability but not the quality of HIV-specific CD8(+) T cells is associated with protective human leucocyte antigen class I alleles in long-term non-progressors
Q35688013Vγ9Vδ2 T-Cell Polyfunctionality Is Differently Modulated in HAART-Treated HIV Patients according to CD4 T-Cell Count

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