Endpoints and other considerations in phase I studies of targeted anticancer therapy: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT)

scientific article published on 24 September 2007

Endpoints and other considerations in phase I studies of targeted anticancer therapy: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT) is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.EJCA.2007.07.034
P698PubMed publication ID17890079

P50authorGiuseppe GiacconeQ37829946
P2093author name stringChristopher M Booth
A Hilary Calvert
Elizabeth A Eisenhauer
Lesley K Seymour
Marinus W Lobbezoo
P433issue1
P304page(s)19-24
P577publication date2007-09-24
P1433published inEuropean Journal of CancerQ332260
P1476titleEndpoints and other considerations in phase I studies of targeted anticancer therapy: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT)
P478volume44

Reverse relations

cites work (P2860)
Q43684447"Classical 3 + 3 design" versus "accelerated titration designs": analysis of 270 phase 1 trials investigating anti-cancer agents.
Q54569640Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer
Q35565672Advances in Statistical Approaches Oncology Drug Development
Q37222606Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?
Q92152744Cumulative Toxicity in Targeted Therapies: What to Expect at the Recommended Phase II Dose
Q37723328Current challenges for the early clinical development of anticancer drugs in the era of molecularly targeted agents
Q33433456Current issues in oncology drug development, with a focus on Phase II trials
Q90493457Design and Conduct Considerations for First-in-Human Trials
Q39463857Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies
Q37198192Dose escalation methods in phase I cancer clinical trials
Q37270128Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities
Q33849805Dose-levels and first signs of efficacy in contemporary oncology phase 1 clinical trials
Q51819134Envisioning the future of early anticancer drug development
Q36238965How many diseases are colorectal cancer?
Q37822199Making the Investigational Oncology Pipeline More Efficient and Effective: Are We Headed in the Right Direction?
Q85498660Meta-analysis of the Relationship Between Dose and Benefit in Phase I Targeted Agent Trials
Q40354212Nature and subjectivity of dose-limiting toxicities in contemporary phase 1 trials: comparison of cytotoxic versus non-cytotoxic drugs
Q37152009Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium.
Q38735014Outcomes and prognostic factors for relapsed or refractory lymphoma patients in phase I clinical trials
Q34941964Phase 0 clinical trials in oncology new drug development
Q33985780Phase 0 clinical trials: recommendations from the Task Force on Methodology for the Development of Innovative Cancer Therapies
Q34440220Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors
Q92445960Phase I cancer clinical trials
Q33728406Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort
Q26865346Phase I trials of antitumour agents: fundamental concepts
Q47223679Potential utility of a longitudinal relative dose intensity of molecularly targeted agents in phase 1 dose-finding trials.
Q51640753Predictors for establishing recommended phase 2 doses: analysis of 320 dose-seeking oncology phase 1 trials
Q47447457Proposal for size justification of expanded cohort at phase-2-recommended dose.
Q43140987Recommended changes to oncology clinical trial design: revolution or evolution?
Q38824605Sequential designs for individualized dosing in phase I cancer clinical trials

Search more.