Transgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis

scientific article published on 22 August 2008

Transgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2249.2008.03723.X
P698PubMed publication ID18727633

P50authorAbel Gutiérrez-OrtegaQ56750557
Rogelio Hernández-PandoQ59978499
P2093author name stringD Aguilar
A L Elías-López
B Marquina
M Gomez-Lim
P2860cites workThe gastrointestinal absorption of liposomally entrapped insulin in normal rats [proceedings]Q67695394
Oral use of human alpha interferon in catsQ67956958
Epidemiology of tuberculosisQ70328865
Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosisQ71764410
The Use of Fluorescein Diacetate and Ethidium Bromide as a Stain for Evaluating Viability of MycobacteriaQ72623810
Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma productionQ73774733
Expression of cholera toxin B subunit in transgenic tomato plantsQ78529703
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Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infectionQ34125021
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosisQ34431001
Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platformsQ34624452
Localization of a bacterial protein in starch granules of transgenic maize kernelsQ35979043
Recombinant interleukin 12 cures mice infected with Leishmania majorQ36361742
Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responsesQ36376548
Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road aheadQ36445550
Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control.Q36960077
Oral administration of insulin by encapsulation within liposomesQ39758120
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Interleukin-12 therapy reduces the number of immune cells and pathology in lungs of mice infected with Mycobacterium tuberculosisQ40764004
Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture.Q41033273
Role of interferon-gamma in interleukin 12-induced pathology in mice.Q42789370
Expression of recombinant human acetylcholinesterase in transgenic tomato plants.Q43759333
Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is presentQ44197418
Microbiology. Chemical warfare and mycobacterial defenseQ44690387
Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measlesQ44750073
Suppression of relapsing experimental autoimmune encephalomyelitis in the SJL/J mouse by oral administration of type I interferonsQ46412993
Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studiesQ48020652
IL-12 promotes drug-induced clearance of Mycobacterium avium infection in miceQ48032359
Expression of functional interleukin-12 from mouse in transgenic tomato plants.Q51313517
IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infectionQ52509109
Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.Q53863572
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Q54195040
The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c miceQ57794668
P433issue1
P921main subjectpulmonary tuberculosisQ13046587
tuberculosisQ12204
murine modelQ122890741
P304page(s)123-133
P577publication date2008-08-22
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleTransgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis
P478volume154

Reverse relations

cites work (P2860)
Q44395612Bifidobacterium as an oral delivery carrier of interleukin-12 for the treatment of Coxsackie virus B3-induced myocarditis in the Balb/c mice
Q52728151Current status and industrialization of transgenic tomatoes
Q35551021IL12B expression is sustained by a heterogenous population of myeloid lineages during tuberculosis.
Q33589495In vivo activity of plant-based interleukin-12 in the lung of Balb/c mouse
Q37484555Interleukin-6: a potent biomarker of mycobacterial infection
Q38121856Plant‐derived pharmaceuticals for the developing world
Q39792117The potential impact of plant biotechnology on the Millennium Development Goals

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