1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells

scientific article published on 01 December 2011

1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2567.2011.03507.X
P698PubMed publication ID22044285

P50authorMihai NeteaQ24517868
Xuehui HeQ56452144
P2093author name stringFrank Preijers
Irma Joosten
Hans J P M Koenen
André J A M van der Ven
Meta Michels
Rob Woestenenk
Ai-Leng Khoo
P2860cites workVitamin D controls T cell antigen receptor signaling and activation of human T cellsQ28275206
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27Q28285583
1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activationQ28370605
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic miceQ28581280
Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profileQ33301251
Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapyQ33373073
Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosisQ33493067
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.Q33606850
Regulatory T cells in the control of immune pathology.Q34348983
Vitamin D: its role and uses in immunologyQ34451101
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.Q34516841
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune diseaseQ34556560
Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNAQ34575360
The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agentsQ34583816
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol)Q34617856
Regulatory T cells in transplantation toleranceQ35092535
Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence.Q35963620
Regulatory T cells and tumor immunityQ36114473
Immunoregulation by 1,25-dihydroxyvitamin D3: basic conceptsQ36208185
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.Q36370315
Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel diseaseQ36430929
Vitamin D physiologyQ36430932
Vitamin D: its role in cancer prevention and treatmentQ36432932
A potential role for vitamin D on HIV infection?Q36505204
Control of autoimmune diseases by the vitamin D endocrine systemQ37204961
1,25-dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitroQ41576405
Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2.Q43007160
1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responsesQ43199222
Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1.Q43290336
Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosisQ43440450
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.Q43775059
Inhibition of human T lymphocyte proliferation and cytokine production by 1,25-dihydroxyvitamin D3. Differential effects on CD45RA+ and CD45R0+ cellsQ44007127
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cellsQ44448880
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cellsQ44521617
Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists.Q46030799
Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity.Q54613192
Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune systemQ66829131
1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitroQ67280107
Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cellsQ73709030
P433issue4
P1104number of pages10
P304page(s)459-468
P577publication date2011-12-01
P1433published inImmunologyQ15754984
P1476title1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells
P478volume134

Reverse relations

cites work (P2860)
Q347443831(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial
Q359816031,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
Q3938607125(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study.
Q3407689225-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings
Q36494694Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses
Q38255387Association of vitamin D receptor gene polymorphisms with asthma risk: systematic review and updated meta-analysis of case-control studies
Q36353718Calcitriol modulates the CD46 pathway in T cells
Q35154069Change in vitamin d levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
Q36218302Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-tuberculosis immune reconstitution inflammatory syndrome
Q41832613Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells
Q36237164Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis
Q39356640High-dose cholecalciferol supplementation significantly increases peripheral CD4⁺ Tregs in healthy adults without negatively affecting the frequency of other immune cells
Q38798523Host and Environmental Factors Influencing Individual Human Cytokine Responses
Q50673352No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children.
Q86931781Pharmacological and pharmacokinetic studies with vitamin D-loaded nanoemulsions in asthma model
Q26774600Protective links between vitamin D, inflammatory bowel disease and colon cancer
Q36085086The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases
Q36723173The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus
Q60916990Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough
Q34550631Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential.
Q54319905Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia.