Abstract is: Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction; it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion does, however, carry a much higher risk of seizure than many other antidepressants and extreme caution must be taken in patients with a history of seizure disorder. Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. Rare but serious side effects include seizure, liver toxicity, psychosis, and risk of overdose. Bupropion use during pregnancy may be associated with increased odds of congenital heart defects. Bupropion acts as a norepinephrine–dopamine reuptake inhibitor and a nicotinic receptor antagonist. However, its effects on dopamine are weak. Chemically, bupropion is an aminoketone that belongs to the class of substituted cathinones and more generally that of substituted amphetamines and substituted phenethylamines. Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in 1969. It was first approved for medical use in the United States in 1985. Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. In 2020, it was the eighteenth most commonly prescribed medication in the United States, with more than 28 million prescriptions. It is on the World Health Organization's List of Essential Medicines.
P3780 | active ingredient in | Aplenzin | Q47521061 |
Wellbutrin | Q47521291 | ||
Forfivo | Q47521628 | ||
Zyban | Q47522363 | ||
Buproban | Q48828815 | ||
Budeprion | Q48829143 | ||
P4250 | defined daily dose | 0.3 | |
P1889 | different from | buprenorphine | Q407721 |
P527 | has part(s) | carbon | Q623 |
P366 | has use | medication | Q12140 |
P3493 | legal status (medicine) | boxed warning | Q879952 |
P8026 | LiverTox likelihood score | LiverTox toxicity likelihood category C | Q83284310 |
P2067 | mass | 239.107692 | |
P2175 | medical condition treated | major depressive disorder | Q42844 |
attention deficit hyperactivity disorder | Q181923 | ||
anxiety | Q154430 | ||
nicotine dependence | Q18553444 | ||
neurotic disorder | Q19000444 | ||
P129 | physically interacts with | solute carrier family 6 member 3 | Q2271947 |
Solute carrier family 6 member 2 | Q7050954 | ||
P3489 | pregnancy category | Australian pregnancy category B2 | Q3679233 |
US pregnancy category C | Q28123617 | ||
P636 | route of administration | oral administration | Q285166 |
intravenous infusion and defusion | Q640448 | ||
inhalation administration | Q4010888 | ||
P769 | significant drug interaction | imipramine | Q58396 |
amitriptyline | Q58397 | ||
clomipramine | Q58713 | ||
zolpidem | Q218842 | ||
paroxetine | Q408471 | ||
linezolid | Q411377 | ||
(S)-duloxetine | Q411932 | ||
trimipramine | Q423498 | ||
rasagiline | Q420685 | ||
moclobemide | Q421934 | ||
fluoxetine | Q422244 | ||
venlafaxine | Q898407 | ||
phenelzine | Q1747559 | ||
(−)-selegiline | Q47495783 | ||
(E/Z)-doxepin | Q71704041 | ||
P9989 | stylized name | buPROPion | |
P2868 | subject has role | antidepressant | Q76560 |
selective serotonin reuptake inhibitor | Q334477 | ||
dopamine reuptake inhibitor | Q899647 | ||
adrenergic uptake inhibitors | Q899668 | ||
second-generation antidepressive agents | Q50430246 | ||
cytochrome P-450 CYP2D6 inhibitors | Q50430508 | ||
P2275 | World Health Organisation international non-proprietary name | bupropion |
FileName: Bupropion-3d-CPK.png
Description: w:Bupropion
Artist: Sbrools
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
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Category:Bupropion | wikimedia | |
Arabic (ar / Q13955) | بوبروبيون | wikipedia |
azb | بوپروپیون | wikipedia |
Catalan (ca / Q7026) | Bupropió | wikipedia |
Bupropion | wikipedia | |
cy | Bwpropion | wikipedia |
Bupropion | wikipedia | |
Bupropion | wikipedia | |
Βουπροπιόνη | wikipedia | |
Bupropion | wikipedia | |
en-simple | Bupropion | wikipedia |
Bupropión | wikipedia | |
Bupropioon | wikipedia | |
Basque language (eu / Q8752) | Bupropion | wikipedia |
Persian (fa / Q9168) | بوپروپیون | wikipedia |
Bupropioni | wikipedia | |
Bupropion | wikipedia | |
gl | Bupropion | wikipedia |
בופרופיון | wikipedia | |
Bupropion | wikipedia | |
Bupropion | wikipedia | |
Bupropion | wikipedia | |
Búprópíón | wikipedia | |
Bupropione | wikipedia | |
ブプロピオン | wikipedia | |
부프로피온 | wikipedia | |
Bupropionum | wikipedia | |
ml | ബ്യൂപ്രോപ്പീയോൺ | wikipedia |
Bupropion | wikipedia | |
or | ବ୍ୟୁପ୍ରୋପିଅନ | wikipedia |
Bupropion | wikipedia | |
Bupropiona | wikipedia | |
Bupropionă | wikipedia | |
Бупропион | wikipedia | |
Serbo-Croatian (sh / Q9301) | Bupropion | wikipedia |
Bupropion | wikipedia | |
Bupropion | wikipedia | |
Bupropion | wikipedia | |
บูโพรพิออน | wikipedia | |
Bupropion | wikipedia | |
Бупропіон | wikipedia | |
Bupropion | wikipedia | |
安非他酮 | wikipedia |
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