Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity

scientific article published on 23 February 2011

Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YJMCC.2011.02.008
P698PubMed publication ID21354172

P50authorAntonio ZazaQ57130638
P2093author name stringMarcella Rocchetti
Matteo Alemanni
Daniele Re
P2860cites workThe inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger functionQ24680113
Effects of aldosterone on transient outward K+ current density in rat ventricular myocytesQ28364342
Integrative analysis of calcium cycling in cardiac muscleQ34101069
Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+Q34169317
Macromolecular complexes regulating cardiac ryanodine receptor function.Q35846632
Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channelsQ36497439
The sarcoplasmic reticulum and arrhythmogenic calcium releaseQ37002270
Overview of emerging pharmacologic agents for acute heart failure syndromesQ37086309
Regulation of current flow through ryanodine receptors by luminal Ca2+.Q41602511
Quantitative assessment of the SR Ca2+ leak-load relationshipQ44167973
Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).Q44186043
Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms.Q44329151
Ouabain increases sarcoplasmic reticulum calcium release in cardiac myocytesQ44666460
Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].Q45171504
Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure modelQ46163987
Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failureQ46556129
Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmiasQ47903909
Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinaseQ48628901
Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes.Q52082843
Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes.Q54361992
Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis).Q54429273
ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of CardiologyQ55050673
Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium WavesQ60182017
The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytesQ60182042
An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytesQ60182097
Kinetics of [Ca]i decline in cardiac myocytes depend on peak [Ca]iQ72491683
Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytesQ73561281
Relative importance of SR load and cytoplasmic calcium concentration in the genesis of aftercontractions in cardiac myocytesQ74271632
P433issue5
P304page(s)910-918
P577publication date2011-02-23
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleRole and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity
P478volume50

Reverse relations

cites work (P2860)
Q41878275Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage
Q37269322Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.
Q42008108Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.
Q41472411Istaroxime, a potential anticancer drug in prostate cancer, exerts beneficial functional effects in healthy and diseased human myocardium
Q36527731Istaroxime: A rising star in acute heart failure
Q42014726SERCA2a stimulation by istaroxime: a novel mechanism of action with translational implications
Q92588956Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials

Search more.