Formulation, stability and immunogenicity of a trivalent pneumococcal protein vaccine formulated with aluminum salt adjuvants

scientific article published on 27 February 2012

Formulation, stability and immunogenicity of a trivalent pneumococcal protein vaccine formulated with aluminum salt adjuvants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2012.02.038
P698PubMed publication ID22381074

P2093author name stringSalvador F Ausar
Annie Dookie
Kevin Harper
Belma Ljutic
Marin Ming
Martina Ochs
Benjamin Messham
P2860cites workEffect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune responseQ82910116
Preformulation studies--The next advance in aluminum adjuvant-containing vaccinesQ84269723
Aluminum salts in vaccines--US perspectiveQ28218439
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvantsQ29615635
Rapid pneumococcal evolution in response to clinical interventionsQ29616646
Application of extrinsic fluorescence spectroscopy for the high throughput formulation screening of aluminum-adjuvanted vaccinesQ33673241
Streptococcus pneumoniae clonal complex 199: genetic diversity and tissue-specific virulenceQ33886611
Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccinesQ33933255
Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsisQ34005995
Mechanisms of stimulation of the immune response by aluminum adjuvantsQ34787679
Pneumococcal Vaccination and Revaccination of Older AdultsQ34926870
Overcharging in colloids: beyond the Poisson-Boltzmann approach.Q35098371
Towards an understanding of the adjuvant action of aluminiumQ35138579
Vaccine Adjuvants: Putting Innate Immunity to WorkQ36168232
Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studiesQ36558990
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiationQ36968256
Serotype-specific problems associated with pneumococcal conjugate vaccinationQ37071137
Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniaeQ37111830
A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniaeQ37333825
Mechanism of action of clinically approved adjuvantsQ37402088
Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) [prevenar 13®].Q37794965
Pneumococcal polysaccharide vaccination for adults: new perspectives for Europe.Q37910264
Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsisQ39023214
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticityQ39576961
Considerations for Formulating the Second-Generation Pneumococcal Capsular Polysaccharide Vaccine with Emphasis on the Cross-Reactive Types Within GroupsQ40166521
Structure-guided antigen engineering yields pneumolysin mutants suitable for vaccination against pneumococcal diseaseQ42708867
Aluminum compounds used as adjuvants in vaccinesQ43747182
Effect of microenvironment pH of aluminum hydroxide adjuvant on the chemical stability of adsorbed antigenQ44788256
Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccineQ45122273
Measuring the surface area of aluminum hydroxide adjuvant.Q52413573
The protective efficacy of polyvalent pneumococcal polysaccharide vaccine.Q53854379
The Influence of Various Adjuvants on the Metabolism of Phospholipids in MacrophagesQ59410967
Population Snapshot of EmergentStreptococcus pneumoniaeSerotype 19A in the United States, 2005Q59538885
Antibody response to pneumococcal vaccination in children younger than five years of ageQ71831864
[Principal comments on active vaccination against poliomyelitis.]Q78582156
P433issue19
P304page(s)2981-2988
P577publication date2012-02-27
P1433published inVaccineQ7907941
P1476titleFormulation, stability and immunogenicity of a trivalent pneumococcal protein vaccine formulated with aluminum salt adjuvants
P478volume30

Reverse relations

cites work (P2860)
Q89734659Adsorption onto aluminum hydroxide adjuvant protects antigens from degradation
Q42272103Aluminum hydroxide influences not only the extent but also the fine specificity and functional activity of antibody responses to tick-borne encephalitis virus in mice
Q38721098Biophysical Characterization and Thermal Stability of Pneumococcal Histidine Triad Protein D in the Presence of Zinc and Manganese
Q34637890Characterization of protective immune responses induced by pneumococcal surface protein A in fusion with pneumolysin derivatives
Q35531214Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children
Q34057765Contributions to protection from Streptococcus pneumoniae infection using the monovalent recombinant protein vaccine candidates PcpA, PhtD, and PlyD1 in an infant murine model during challenge
Q34866385Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker.
Q90564961Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens
Q52365761Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1.
Q42036323Mechanism of immunopotentiation and safety of aluminum adjuvants.
Q37174555Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms
Q57478910Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want
Q37264979Phosphate substitution in an AlOOH - TLR4 adjuvant system (SPA08) modulates the immunogenicity of Serovar E MOMP from Chlamydia trachomatis
Q89969392Protection of outbred mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant
Q104105760Rapid developability assessments to formulate recombinant protein antigens as stable, low-cost, multi-dose vaccine candidates: Case-study with non-replicating rotavirus (NRRV) vaccine antigens
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Q87680192Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model
Q37668409Working together: interactions between vaccine antigens and adjuvants

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