Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

scientific article published on 01 May 2011

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.201041014
P698PubMed publication ID21469103

P2093author name stringTim Sparwasser
Wolfgang Reindl
Jakob Loschko
Anne B Krug
Daniela Hackl
P2860cites workSpecies-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Q24310398
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathwayQ28216760
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAQ28513215
Molecular antagonism and plasticity of regulatory and inflammatory T cell programsQ29619478
Yaa autoimmune phenotypes are conferred by overexpression of TLR7.Q34356566
Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharideQ34531452
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosusQ34574768
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cellsQ36156864
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cellsQ36399149
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusQ36403653
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.Q36403678
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.Q36403992
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsQ36699777
In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host diseaseQ36843821
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.Q36893657
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cellsQ36985100
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylationQ37065897
T-regulatory cells in systemic lupus erythematosusQ37168023
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferationQ37252315
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responsesQ37267529
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivoQ37312884
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like diseaseQ38306073
U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.Q38317464
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin miceQ40231922
Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cellsQ43258134
Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccinationQ45400025
Toll-dependent control mechanisms of CD4 T cell activation.Q51996404
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expressionQ59048389
Global Natural Regulatory T Cell Depletion in Active Systemic Lupus ErythematosusQ61050853
Immunostimulatory RNA Blocks Suppression by Regulatory T CellsQ63408458
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functionsQ79445141
Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritisQ81000977
Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupusQ81527709
P433issue5
P921main subjectdendritic cellQ506253
P304page(s)1334-1343
P577publication date2011-05-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleActivation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs
P478volume41