The Ala allele in the PPAR-gamma2 gene is associated with reduced risk of type 2 diabetes mellitus in Caucasians and improved insulin sensitivity in overweight subjects

scientific article published on 27 April 2010

The Ala allele in the PPAR-gamma2 gene is associated with reduced risk of type 2 diabetes mellitus in Caucasians and improved insulin sensitivity in overweight subjects is …
instance of (P31):
meta-analysisQ815382
scholarly articleQ13442814

External links are
P356DOI10.1017/S0007114510000851
P698PubMed publication ID20420754

P50authorGrazielle HugueninQ62132534
P2093author name stringGlorimar Rosa
P2860cites workThe common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetesQ24290189
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manQ26776977
Measuring inconsistency in meta-analysesQ27860655
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin ResiQ31035230
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetesQ33899154
Genetics of the metabolic syndromeQ33964734
The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivityQ34348367
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivityQ38331543
Genetic variation in the peroxisome proliferator-activated receptor-gamma2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regainQ40689616
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesityQ43542493
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivityQ43566173
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasiansQ43763530
PPARgamma2 pro12Ala polymorphism and insulin resistance in Japanese hypertensive patients.Q43940848
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention StudyQ44081023
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish populationQ44172019
PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese populationQ44196997
Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian populationQ44210344
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjectsQ44325204
Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementationQ44452896
Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12AlaQ44473943
Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetesQ44599756
Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphismsQ44629006
Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemiaQ44697252
High incidence of type 2 diabetes in peroxisome proliferator-activated receptor gamma2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acidsQ45034145
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosisQ45050542
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trialQ45183730
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography studyQ46458639
Association between Pro12Ala polymorphism of the PPAR-gamma2 gene and insulin sensitivity in Brazilian patients with type-2 diabetes mellitus.Q46623854
Hyperinsulinemia is an independent predictor for complex atherosclerotic lesion of thoracic aorta in non-diabetic patientsQ46743359
Effects of two common polymorphisms of peroxisome proliferator-activated receptor-gamma gene on metabolic syndromeQ46824955
Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetesQ47330796
Clustering of cardiovascular risk factors in hyperinsulinemia in Japanese without diabetes.Q50869061
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.Q51486794
Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid.Q51491761
Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity.Q51499010
Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study.Q51536333
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.Q51549887
Evidence for gene-nutrient interaction at the PPARgamma locus.Q51550350
Contribution of fasting hyperinsulinemia to prediction of atherosclerotic cardiovascular disease status in 293 hyperlipidemic patients.Q51559659
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.Q54090156
Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populationsQ57242012
Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitusQ57605988
The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor- 2 Gene on Glucose/Insulin Metabolism Interact With Prenatal Exposure to FamineQ58992827
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetesQ73658806
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitusQ77906021
P433issue4
P921main subjecttype 2 diabetesQ3025883
P304page(s)488-497
P577publication date2010-04-27
P1433published inBritish Journal of NutritionQ4970206
P1476titleThe Ala allele in the PPAR-gamma2 gene is associated with reduced risk of type 2 diabetes mellitus in Caucasians and improved insulin sensitivity in overweight subjects
P478volume104

Reverse relations

cites work (P2860)
Q44254466Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics
Q37136093Association between PRO12ALA polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in Iranian patients
Q37567750Association of PPARG Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome
Q84449805Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: a meta-analysis
Q48892922Associations between C1431T and Pro12Ala variants of PPARγ gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population.
Q82274977Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study
Q26750792Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma
Q36306320Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity
Q36239731Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene and diabetic retinopathy in Caucasians and Asians
Q98164364PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis
Q92679171PPARγ Pro12Ala Polymorphism Influences the Relationship between Dietary Fat Intake, Adiposity and Lipid Profile in Patients with Type 2 Diabetes
Q35808814PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome
Q37634074PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet
Q34803775PPARγ2 Pro12Ala polymorphism was associated with favorable cardiometabolic risk profile in HIV/HCV coinfected patients: a cross-sectional study
Q31132059The association between the Pro12Ala variant in the PPARγ2 gene and type 2 diabetes mellitus and obesity in a Chinese population

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