Peptic ulcer disease

scientific article published on 13 August 2009

Peptic ulcer disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0140-6736(09)60938-7
P698PubMed publication ID19683340

P50authorFrancis Ka-Ming ChanQ42153384
P2093author name stringPeter Malfertheiner
Kenneth E L McColl
P2860cites workProstaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?Q22306448
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trialsQ24546221
The role of gastrin in ulcer pathogenesisQ73629005
Cure of Helicobacter pylori-associated ulcer disease through eradicationQ73629031
The acid response to gastrin distinguishes duodenal ulcer patients from Helicobacter pylori-infected healthy subjectsQ74036159
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 productionQ74531603
Clinical and endoscopic characteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: a long-term prospective studyQ77331394
A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcerQ77331416
Current or recent proton pump inhibitor therapy markedly impairs the accuracy of the [14C]urea breath testQ77608865
Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized studyQ77769244
Pretreatment antibiotic resistance in Helicobacter pylori infection: results of three randomized controlled studiesQ77923132
Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trialQ79676511
Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritisQ79798187
Risk of peptic ulcer hospitalizations in users of NSAIDs with gastroprotective cotherapy versus coxibsQ81248684
Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcerQ82896112
Amino terminus and the first four membrane-spanning segments of the Arabidopsis K+ channel KAT1 confer inward-rectification property of plant-animal chimeric channelsQ95805985
Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus ReportQ24674636
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxenQ28164178
Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic reviewQ28194969
Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trialsQ28200013
Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control studyQ28200506
Is ranitidine therapy sufficient for healing peptic ulcers associated with non-steroidal anti-inflammatory drug use?Q28201393
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trialQ28210388
Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic reviewQ28212850
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleedingQ28213463
Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trialQ28216474
Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinationsQ28217824
Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatmentQ28218361
Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general populationQ28218399
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in womenQ28218670
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complicationsQ28219448
Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulantsQ28219972
Cure of duodenal ulcer associated with eradication of Helicobacter pyloriQ28256637
Unidentified curved bacilli on gastric epithelium in active chronic gastritisQ28261151
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulcerationQ29547429
Causes underlying the birth-cohort phenomenon of peptic ulcer: analysis of mortality data 1911-2000, England and WalesQ31041312
Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment studyQ33175376
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Guidelines for prevention of NSAID-related ulcer complicationsQ33412100
Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsiaQ33619704
Should non-invasive Helicobacter pylori testing replace endoscopy in investigation of dyspepsia?Q33903435
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Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysisQ34247727
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPaseQ34252248
Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcerQ34377376
Gastrin and somatostatin in Helicobacter pylori infected antral mucosaQ34378628
Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcersQ34393522
Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazoleQ34407809
Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulbQ34410052
Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status.Q51565479
Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.Q51599679
In vivo assessment of the gastric mucosal tolerance dose after single fraction, small volume irradiation of liver malignancies by computed tomography-guided, high-dose-rate brachytherapy.Q52932463
Patterns of inflammation linked to ulcer diseaseQ56157321
CIVILISATION AND PEPTIC ULCER*1Q56830457
Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysisQ56929040
Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugsQ57945428
Potent ulcerogenic actions of platelet-activating factor on the stomachQ59065369
H. pylori-negative duodenal ulcer prevalence and causes in 774 patientsQ59509874
Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcersQ61570355
The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcerQ61960636
The MACH2 study: Role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapiesQ61960641
Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcerQ63409765
Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory DrugsQ67903664
Plasma Gastrin, Daytime Intragastric pH, and Nocturnal Acid Output before and at 1 and 7 Months after Eradication ofHelicobacter pyloriin Duodenal Ulcer SubjectsQ67917465
Blood lymphocyte proliferation, cytokine secretion and appearance of T cells with activation surface markers in cultures with Helicobacter pylori. Comparison of the responses of subjects with and without antibodies to H. pyloriQ67984886
The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelinQ68523385
Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infectionQ70525503
Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulcerationQ70912581
A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcerQ71035846
Eradication of Helicobacter pylori reduces the possibility of rebleeding in peptic ulcer diseaseQ72114814
Salicylate Damage to the Gastric Mucosal BarrierQ72219865
Helicobacter pylori infection: genetic and environmental influences. A study of twinsQ72424515
Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pyloriQ72638584
Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trialQ72669446
Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugsQ72674958
Treatment of Helicobacter pylori reduces the rate of rebleeding in peptic ulcer diseaseQ72715711
Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitroQ41392086
The clinical relevance of strain types of Helicobacter pyloriQ41552242
Asymptomatic peptic ulcer diseaseQ42559696
Gastric mucosal barrier: evidence for Helicobacter pylori ingesting gastric surfactant and deriving protection from it.Q43212856
Healing of duodenal ulcer after eradication of Helicobacter heilmannii.Q43997322
Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice.Q44077396
Impact of Helicobacter pylori eradication on heartburn in patients with gastric or duodenal ulcer disease -- results from a randomized trial programmeQ44105244
Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritisQ44165133
Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatmentQ44214971
Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer diseaseQ44215910
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritisQ44261800
Contribution of HLA-DQA gene to host's response against Helicobacter pyloriQ44266538
Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugsQ44443132
Second‐line treatment for failure to eradicate Helicobacter pylori: a randomized trial comparing four treatment strategiesQ44611978
The importance of biopsychosocial factors in the development of duodenal ulcer in a cohort of middle-aged menQ44743485
Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial.Q45104115
Rifabutin- and furazolidone-based Helicobacter pylori eradication therapies after failure of standard first- and second-line eradication attempts in dyspepsia patientsQ45219635
Second-line treatment for Helicobacter pylori infection based on moxifloxacin triple therapy: a randomized controlled trialQ46099612
A prospective study of gastric and duodenal ulcer and its relation to smoking, alcohol, and dietQ46327283
Effect of esomeprazole triple therapy on eradication rates of Helicobacter pylori, gastric ulcer healing and prevention of relapse in gastric ulcer patientsQ46604034
Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazoleQ46982445
Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pyloriQ47900027
A survey of stress ulcer prophylaxis in Intensive Care Units in the UK.Q48611773
Differing patterns of Helicobacter pylori gastritis in patients with duodenal, prepyloric, and gastric ulcer disease.Q50900413
Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product.Q50989183
Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysisQ34520598
The relative efficacies of gastroprotective strategies in chronic users of nonsteroidal anti-inflammatory drugsQ34588716
A population-based study of the drug interaction between proton pump inhibitors and clopidogrelQ34603772
American College of Gastroenterology guideline on the management of Helicobacter pylori infectionQ34645482
Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pyloriQ34651921
Review article: Helicobacter pylori "rescue" regimen when proton pump inhibitor-based triple therapies fail.Q34657352
Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleedingQ34714596
Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trialQ34720605
Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer diseaseQ34721129
Bellyaching in these pages: upper gastrointestinal disorders in Psychosomatic medicineQ34883020
ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus DocumentsQ34883156
Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndromeQ34956075
Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDsQ35030551
Helicobacter pylori infection and perforated peptic ulcer prevalence of the infection and role of antimicrobial treatment.Q35129759
Natural history of gastritis and its relationship to peptic ulcer diseaseQ35378921
Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients: a randomised, double blind, placebo controlled, clinical trialQ35594930
The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese populationQ35597205
Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adultsQ35598340
Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID usersQ36158848
Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure.Q36360546
Levofloxacin-based triple therapy versus bismuth-based quadruple therapy for persistent Helicobacter pylori infection: a meta-analysisQ36423165
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesinQ36556507
Magnitude and economic impact of inappropriate use of stress ulcer prophylaxis in non-ICU hospitalized patientsQ36585284
Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.Q36591918
Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.Q36820902
Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the National Audit of Acute Upper Gastrointestinal HaemorrhageQ36904361
Helicobacter pylori urease activity is toxic to human gastric epithelial cells.Q36984967
NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizonQ36998760
Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin?Q37044230
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsQ37047617
Cushing's ulcer in traumatic brain injury.Q37123651
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigensQ38313312
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses.Q39984099
Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis onlyQ40198420
Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injuryQ40689497
P433issue9699
P407language of work or nameEnglishQ1860
P304page(s)1449-1461
P577publication date2009-08-13
P1433published inThe LancetQ939416
P1476titlePeptic ulcer disease
P478volume374

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Q37328142Perforated duodenal ulcer presenting with a subphrenic abscess revealed by plain abdominal X-ray films and confirmed by multi-detector computed tomography: a case report.
Q28084426Perforated peptic ulcer
Q64917613Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study.
Q92063898Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer
Q38804396Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents
Q38848225Potential role of probiotics in the management of gastric ulcer
Q36591044Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes
Q55095896Propolis and Its Potential to Treat Gastrointestinal Disorders.
Q35116152Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats
Q47159334Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice
Q94326811Proton pump inhibitor‐ and fluoroquinolone‐based triple therapies for eradication
Q41996131Proton-pump inhibitors: understanding the complications and risks
Q36616851Quadruple therapy for eradication of Helicobacter pylori
Q34299125Randomized controlled trial comparing 7-day triple, 10-day sequential, and 7-day concomitant therapies for Helicobacter pylori infection
Q64890427Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer.
Q49911269Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs
Q47801037Relationship between Adverse Gastric Reactions and the Timing of Enteric-Coated Aspirin Administration
Q28538491Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: gastroprotective and ulcer healing properties in rats
Q42852402Risk factors for development and recurrence of peptic ulcer disease
Q37661702Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease
Q34255432Role of Helicobacter pylori infection on nutrition and metabolism
Q28088459Role of dietary polyphenols in the management of peptic ulcer
Q37616472Salivary enzymes in peptic ulcer disease
Q90307705Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study
Q50217701Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells
Q48225195Sequential versus concomitant therapy for treatment of Helicobacter pylori infection: an updated systematic review and meta-analysis
Q64226721Serum protein expression in Equine Glandular Gastric Disease (EGGD) induced by phenylbutazone
Q33612306Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population
Q61447265Statins and gastroduodenal endoscopic lesions: A case-control study
Q35239157Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of Chresta martii DC. and Identification of Its Principal Compounds
Q36838164Subtotal Gastrectomy With Billroth II Anastomosis Is Associated With a Low Risk of Ischemic Stroke in Peptic Ulcer Disease Patients: A Nationwide Population-Based Study
Q90457114Surgical repair of perforated peptic ulcers: laparoscopic versus open approach
Q88787445Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives
Q89682811Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases
Q38001425Tannins, peptic ulcers and related mechanisms
Q58700546Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicen
Q40129982Ten-Day Quadruple Therapy Comprising Proton Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin is More Effective than Standard Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori Infection: A Randomized Controlled Tr
Q34508052The 5300-year-old Helicobacter pylori genome of the Iceman
Q36205817The Development of Diabetes after Subtotal Gastrectomy with Billroth II Anastomosis for Peptic Ulcer Disease
Q64093567The Interaction of Infection and Type 2 Diabetes Mellitus
Q64092764The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation
Q94571823The analysis of risk for peptic ulcer disease using Korean national health and nutrition examination survey: a cross-sectional analysis of a national survey sample
Q40073407The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article
Q37071499The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.
Q35029133The prevalence of helicobacter pylori among dyspeptic patients in an earthquake-stricken area
Q26784036The stomach in health and disease
Q33838470Therapeutic Applications of Rose Hips from Different Rosa Species.
Q38032319Therapeutic management of recurrent peptic ulcer disease
Q34508830Treatment of Helicobacter pylori infection: Past, present and future
Q38238745Treatment of Helicobacter pylori infection: meeting the challenge of antimicrobial resistance
Q35647007Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample
Q35132193Trends in diagnosis and surgical management of patients with perforated peptic ulcer
Q35825245Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus.
Q34062323Ulcerogenic Helicobacter pylori strains isolated from children: a contribution to get insight into the virulence of the bacteria
Q33893567Update on the first-line treatment for Helicobacter pylori infection - a continuing challenge from an old enemy
Q27002380Upper gastrointestinal microbiota and digestive diseases
Q35188639Weekly pattern of emergency room admissions for peptic ulcers: a population-based study
Q40023559When Should Antiplatelet Agents Be Resumed After Successful Endoscopic Hemostasis in Patients with Peptic Ulcer Bleeding?

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