Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection

scientific article published on 17 August 2012

Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1018736758
P356DOI10.1007/S00439-012-1220-0
P698PubMed publication ID22898894

P50authorJohn GuytonQ37842174
P2093author name stringKeyur Patel
Allen D Roses
Ornit Chiba-Falek
Stephen D Gardner
Jeanette J McCarthy
Colton Linnertz
P2860cites workReliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virusQ21090530
Dissection of the mitochondrial import and assembly pathway for human Tom40Q24337791
Apolipoprotein 3 allele is associated with persistent hepatitis C virus infectionQ27478309
Association of apolipoprotein E genotypes with lipid levels and coronary riskQ28249437
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single siteQ28264429
Characterization of the poly-T variant in the TOMM40 gene in diverse populationsQ28732044
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994Q29620136
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart StudyQ30484496
Haploview: Visualization and analysis of SNP genotype dataQ33530583
APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structureQ33691358
Genetic variation at a single locus and age of onset for Alzheimer's disease.Q33870512
Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.Q34065725
IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.Q34142463
A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's diseaseQ34159318
The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virusQ34190545
Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.Q34295937
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levelsQ35138365
Changes in lipid metabolism in chronic hepatitis C.Q35165949
Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolismQ35246448
Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.Q35337926
Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.Q35696751
Metabolic and cardiovascular risk profiles and hepatitis C virus infection in rural EgyptQ35956085
Correlation between beta-lipoprotein levels and outcome of hepatitis C treatmentQ36548487
IL28B and the Control of Hepatitis C Virus InfectionQ37800518
Assembly of infectious hepatitis C virus particlesQ37819269
Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels: a community-based studyQ42978491
Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1.Q42981658
Carriage of the apolipoprotein E-epsilon4 allele and histologic outcome of recurrent hepatitis C after antiviral treatment.Q42987472
Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.Q42996760
Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination SurveysQ42998640
Beta-lipoproteins influence the serum level of hepatitis C virus.Q43029944
Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infectionQ43035003
Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosisQ43048093
Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infectionQ43224504
Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C.Q43588122
Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene clusterQ44858774
Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patientsQ45728692
Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virusQ45731567
Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective studyQ45737816
Blood lipids of patients with chronic hepatitis: differences related to viral etiology.Q50949484
Lipid metabolism in children with chronic hepatitis C, A preliminary report.Q51483847
The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.Q51918191
Serum lipid profile of patients with genotype 1b hepatitis C viral infection in JapanQ73281202
Serum cholesterol and low-density lipoprotein cholesterol levels as predictors of response to interferon therapy for chronic hepatitis CQ73728277
Allelic discrimination using fluorogenic probes and the 5' nuclease assayQ74618454
Long-term reversal of hypocholesterolaemia in patients with chronic hepatitis C is related to sustained viral response and viral genotypeQ80054974
Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis CQ80323229
Apolipoprotein E genotypes modulate fibrosis progression in patients with chronic hepatitis C and persistently normal transaminasesQ83284557
P433issue12
P921main subjectpleiotropyQ1134884
P304page(s)1911-1920
P577publication date2012-08-17
P1433published inHuman GeneticsQ5937167
P1476titlePleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection
P478volume131

Reverse relations

cites work (P2860)
Q92350874A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
Q34753579Alzheimer's disease and infections, where we stand and where we go.
Q47625969Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses
Q37285273Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
Q34706979The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer's Disease
Q64087216The Genetic Variability of in Different Human Populations and Its Implications for Longevity
Q38722398The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster