4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor (scientific article published on 06 September 2010)

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Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis.

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells

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PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation.

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Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations

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Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells.

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Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis.

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NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.

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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells.

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Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans

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Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays

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A cross-sectional investigation of biomarkers of risk after a decade of smoking.

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Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27.

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P433

issue

P304

page(s)

106-116

P577

publication date

2010-09-06

P1433

published in

Oncogene

Q1568657

P1476

title

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor

P478

volume

Reverse relations

cites work (P2860)

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