Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells

scientific article published on 02 November 2012

Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2012.10.011
P698PubMed publication ID23127514

P50authorMichiie SakamotoQ114433538
P2093author name stringKen Yamazaki
Yohei Masugi
Kathryn Effendi
Keiji Tanese
Mariko Fukuma
Mariko Suda
P2860cites workLgr5 marks cycling, yet long-lived, hair follicle stem cells.Q53447869
LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell linesQ21560941
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorQ24328829
Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distensionQ24561753
Wnt signal transduction pathwaysQ24641814
Stem cells, cancer, and cancer stem cellsQ27860878
Identification of stem cells in small intestine and colon by marker gene Lgr5Q28131701
Crypt stem cells as the cells-of-origin of intestinal cancerQ28304418
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitorQ29614622
Applying the principles of stem-cell biology to cancerQ29622827
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutationsQ34179347
Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumorsQ34507214
G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation.Q36855733
Adenomatous polyposis coli (APC) protein regulates epithelial cell migration and morphogenesis via PDZ domain-based interactions with plasma membranesQ40171921
Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.Q40508457
LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestineQ43579801
P433issue3
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)113-121
P577publication date2012-11-02
P1433published inExperimental Cell ResearchQ1524289
P1476titleLeucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells
P478volume319

Reverse relations

cites work (P2860)
Q37660299CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.
Q90776672Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
Q33889222Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma.
Q33688716Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma
Q42611886HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
Q37404543Knockdown of LGR5 suppresses the proliferation of glioma cells in vitro and in vivo
Q41408678LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.
Q35849680Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer
Q48198419Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+) liver cancer initiating cells by suppressing negative regulators of β-catenin signaling.
Q55100149Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish.
Q26797525Overexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular Carcinoma
Q38751204Overexpression of MicroRNA-216a Suppresses Proliferation, Migration, and Invasion of Glioma Cells By Targeting Leucine-rich Repeat-containing G Protein-coupled Receptor 5.
Q59354523Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 predicts poor prognosis in hepatocellular carcinoma
Q53339535Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas.
Q92650461Regulatory T Cells Promote Overexpression of Lgr5 on Gastric Cancer Cells via TGF-beta1 and Confer Poor Prognosis in Gastric Cancer

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