SjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice

scientific article published on 21 June 2015

SjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1042960791
P356DOI10.1007/S00436-015-4567-Z
P698PubMed publication ID26091761

P2093author name stringQun Liu
Jiao-Jiao Lin
Yun Yan Li
Chun Xiu Yuan
Xin Gang Feng
Guo Feng Cheng
Ming Ming Duan
Rui Min Xu
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Molecular and functional characterization of a mortalin-like protein from Schistosoma japonicum (SjMLP/hsp70) as a member of the HSP70 familyQ33625124
Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70.Q33648551
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DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.Q34009516
Th1 stimulatory proteins of Leishmania donovani: comparative cellular and protective responses of rTriose phosphate isomerase, rProtein disulfide isomerase and rElongation factor-2 in combination with rHSP70 against visceral leishmaniasisQ34277331
Candidate vaccine antigens identified by antibodies from mice vaccinated with 15- or 50-kilorad-irradiated cercariae of Schistosoma mansoniQ34521287
Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armourQ35000247
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Immunostimulatory functions of membrane-bound and exported heat shock protein 70.Q36356898
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.Q36576646
Intravenous transfer of apoptotic cell-treated dendritic cells leads to immune tolerance by blocking Th17 cell activityQ37026218
Sensing danger--Hsp72 and HMGB1 as candidate signals.Q37044348
Radiation-attenuated schistosome vaccination--a brief historical perspectiveQ37425288
Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogenQ37490474
Proteomic analysis of schistosomiasis japonica vaccine candidate antigens recognized by UV-attenuated cercariae-immunized porcine serum IgG2.Q38489789
Immunization of baboons with attenuated schistosomula of Schistosoma haematobium: levels of protection induced by immunization with larvae irradiated with 20 and 60 kradQ39051086
Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection.Q39051597
A dominant B-cell epitope on the 22 kDa tegumental membrane-associated antigen of Schistosoma japonicum maps to an EF-hand calcium binding domainQ39568381
The heat shock proteins, Hsp70 and Hsp83, of Leishmania infantum are mitogens for mouse B cellsQ39956943
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.Q40005411
Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine releaseQ41010028
Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell deathQ42115292
DNA vaccines encoding membrane-bound or secreted forms of heat shock protein 70 exhibit improved potencyQ42225249
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilizationQ42971215
Exposed proteins of the Schistosoma japonicum tegumentQ43255769
Antigen localization and the induction of resistance in mice vaccinated with irradiated cercariae of Schistosoma mansoniQ44025761
Observations on cattle schistosomiasis in the Sudan, a study in comparative medicine. III. Field testing of an irradiated Schistosoma bovis vaccine.Q46972787
Identification of Th1 epitopes within molecules from the lung-stage schistosomulum of Schistosoma japonicum by combining prediction analysis of the transcriptome with experimental validationQ47727969
Humoral immune response to the 72 kDa heat shock protein from Plasmodium falciparum in populations at hypoendemic areas of malaria in western Brazilian AmazonQ48036532
[Schistosomiasis status in People's Republic of China in 2010].Q51180297
Schistosoma japonicum: proteomics analysis of differentially expressed proteins from ultraviolet-attenuated cercariae compared to normal cercariae.Q51766277
Delayed-type hypersensitivity elicited by synthetic peptides complexed with Mycobacterium tuberculosis hsp 70.Q52045219
Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines.Q53658056
Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes.Q53927474
Immunization of rats against Schistosoma mansoni using irradiated cercariae, lung schistosomula and liver-stage worms.Q54467337
Isolation and characterization of a protective antigen for adjuvant-free immunization against Schistosoma mansoniQ56950609
Heat shock protein 70 fused to or complexed with Hantavirus nucleocapsid protein significantly enhances specific humoral and cellular immune responses in C57BL/6 miceQ59279871
The ability of fractionated sera from animals vaccinated with irradiated cercariae of Schistosoma mansoni to transfer immunity to miceQ69057896
Vaccination against Schistosoma mansoni infection using 74 kDa Schistosoma protein antigenQ78100549
[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]Q78875574
Vaccination against Schistosomiasis: The case for Lung-stage AntigensQ79239621
Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cellsQ80833079
Innate immune response in Th1- and Th2-dominant mouse strainsQ80873433
Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytesQ81672080
Cocktail of gp63 and Hsp70 induces protection against Leishmania donovani in BALB/c miceQ83176489
P433issue9
P921main subjectSchistosoma japonicumQ1256989
P304page(s)3415-3429
P577publication date2015-06-21
P1433published inParasitology ResearchQ15755242
P1476titleSjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice
P478volume114

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cites work (P2860)
Q90004065Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel
Q40233001Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection
Q99238493Proteomics Analysis of Hydatigera taeniaeformis Metacestode Stage
Q49539680Schistosoma Infection and Schistosoma-Derived Products Modulate the Immune Responses Associated with Protection against Type 2 Diabetes
Q44497423SjCRT, a recombinant Schistosoma japonicum calreticulin, induces maturation of dendritic cells and a Th1-polarized immune response in mice