Tandem mass spectrometry study of C-phenyl-N-tert-butyl nitrone spin adducts from in vitro rat liver microsomal metabolism of bromotrichloromethane and carbon tetrachloride

scientific article published on 01 September 1995

Tandem mass spectrometry study of C-phenyl-N-tert-butyl nitrone spin adducts from in vitro rat liver microsomal metabolism of bromotrichloromethane and carbon tetrachloride is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1006484829
P356DOI10.1016/1044-0305(95)00328-B
P698PubMed publication ID24214427

P2093author name stringH Sang
Y Kotake
E G Janzen
J L Poyer
C M Dubose
M Arimura
P2860cites workChemistry and biology of spin-trapping radicals associated with halocarbon metabolism in vitro and in vivoQ35035619
Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethaneQ39184713
Characterization of the free radical formed in aerobic microsomal incubations containing carbon tetrachloride and NADPH.Q39279749
Spin trapping of superoxide and hydroxyl radical: practical aspectsQ40119727
In vivo spin-trapping of trichloromethyl radicals formed from CCl4Q40264932
Spin-trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions isolated hepatocytes and in vivo in the ratQ41876199
Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermosprayQ42161910
Detection of radical species in haematin-catalysed retinoic acid 5,6-epoxidation by using h.p.l.c.-e.p.r. spectrometryQ42165437
Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,Q42244676
Carbon radicals in the metabolism of alkyl hydrazinesQ42246400
Structure identification of free radicals by ESR and GC/MS of PBN spin adducts from the in vitro and in vivo rat liver metabolism of halothane.Q51743259
Phenyl radical production during the oxidation of phenylhydrazine and in phenylphydrazine-induced haemolysisQ60786804
Stabilities of hydroxyl radical spin adducts of PBN-type spin traps☆Q67487370
Detection of the ethyl- and pentyl-radical adducts of alpha-(4-pyridyl-1- oxide)-N-tert-butylnitrone in rat-liver microsomes treated with ADP, NADPH and ferric chlorideQ67494839
Combined liquid chromatography/electron paramagnetic resonance spectrometry/electrospray ionization mass spectrometry for radical identificationQ67507201
Isolation and identification of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenaseQ67912636
Radical identification by liquid chromatography/thermospray mass spectrometryQ68400226
Mass spectroscopy and chromatography of the trichloromethyl radical adduct of phenyl tert-butyl nitroneQ68473305
Separation of polyunsaturated fatty acid radicals by high-performance liquid chromatography with electron spin resonance and ultraviolet detectionQ69344449
Factors influencing the formation of the carbon dioxide radical anion (.CO2-) spin adduct of PBN in the rat liver metabolism of halocarbonsQ69851818
Detection of free radicals generated from the in vitro metabolism of carbon tetrachloride using improved ESR spin trapping techniquesQ69852433
Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazineQ70121468
Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitroQ70191632
Free radical intermediates under hypoxic conditions in the metabolism of halogenated carcinogensQ70405278
Characteristics of an oxidant formed during iron (II) autoxidationQ71999762
Oxygen radical formation in well-washed rat liver microsomes: spin trapping studiesQ72017789
Oxidative metabolism of hydralazine. Evidence for nitrogen centered radicals formationQ72935306
Spin-trapped Radicals: Determination by LC-TSP-MS and LC-ESI-MSQ86762573
P433issue9
P304page(s)847-853
P577publication date1995-09-01
P1433published inJournal of the American Society for Mass SpectrometryQ3020250
P1476titleTandem mass spectrometry study of C-phenyl-N-tert-butyl nitrone spin adducts from in vitro rat liver microsomal metabolism of bromotrichloromethane and carbon tetrachloride
P478volume6

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cites work (P2860)
Q73503915Aromatic hydroxylation in PBN spin trapping by hydroxyl radicals and cytochrome P-450
Q74704800Clarification of the relationship between free radical spin trapping and carbon tetrachloride metabolism in microsomal systems
Q73268914The structure of free radical metabolites detected by EPR spin trapping and mass spectroscopy from halocarbons in rat liver microsomes

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