Chiral Separation of Uncharged Pomalidomide Enantiomers Using Carboxymethyl-β-Cyclodextrin: A Validated Capillary Electrophoretic Method

scientific article published on 28 December 2015

Chiral Separation of Uncharged Pomalidomide Enantiomers Using Carboxymethyl-β-Cyclodextrin: A Validated Capillary Electrophoretic Method is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CHIR.22563
P698PubMed publication ID26708721

P2093author name stringGergő Tóth
Zoltán-István Szabó
Daniela-Lucia Muntean
Levente Szőcs
Béla NoszáL
P2860cites workCereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideQ24614147
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A double-blind study of the sedative effects of the thalidomide enantiomers in humansQ48766029
Investigation of the enantiomerization barriers of the phthalimidone derivatives EM12 and lenalidomide by dynamic electrokinetic chromatography.Q50994881
A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma.Q53628417
Modeling and simulation to probe the pharmacokinetic disposition of pomalidomide R- and S-enantiomers.Q55058282
Investigations on the in vitro racemization of thalidomide by high-performance liquid chromatographyQ55968708
Investigation of the in vitro biotransformation and simultaneous enantioselective separation of thalidomide and its neutral metabolites by capillary electrophoresisQ71489111
Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analoguesQ71742426
Investigation of the stereoselective in vitro biotransformation of thalidomide using a dual cyclodextrin system in capillary electrophoresisQ72990981
Enantioseparation of thalidomide and its hydroxylated metabolites using capillary electrophoresis with various cyclodextrins and their combinations as chiral buffer additivesQ73024844
Identification and characterization of related substances in pomalidomide by hyphenated LC-MS techniquesQ85321779
P433issue3
P921main subjectchiralityQ214514
enantiomerQ494483
P304page(s)199-203
P577publication date2015-12-28
P1433published inChiralityQ2120255
P1476titleChiral Separation of Uncharged Pomalidomide Enantiomers Using Carboxymethyl-β-Cyclodextrin: A Validated Capillary Electrophoretic Method
P478volume28

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cites work (P2860)
Q39030333Chiral selectors in CE: Recent development and applications (mid-2014 to mid-2016).
Q47763989Enantioselective resolution of 4-chloromandelic acid by liquid-liquid extraction using 2-chloro-N-carbobenzyloxy-L-amino acid.
Q50881127Validated capillary electrophoretic method for the enantiomeric quality control of R-praziquantel.

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