Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial

scientific article published on 05 August 2013

Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2013.48.8585
P698PubMed publication ID23918952

P2093author name stringMin Tao
Jin Li
Xiaodong Zhu
Ying Cheng
Xin Liu
Liwei Wang
Shukui Qin
Yan Yang
Guoping Sun
Jianming Xu
Hao Yu
Dongmei Ji
Yuxian Bai
Nong Xu
Zhehai Wang
Weijian Guo
Leizhen Zheng
Jianping Xiong
P433issue26
P921main subjectphase II clinical trialQ42824440
placeboQ269829
P304page(s)3219-3225
P577publication date2013-08-05
P1433published inJournal of Clinical OncologyQ400292
P1476titleApatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial
P478volume31

Reverse relations

cites work (P2860)
Q36195933A Case Report of Gastrointestinal Hemorrhage and Perforation During Apatinib Treatment of Gastric Cancer
Q92402681A Single-Arm, Phase II Study of Apatinib in Refractory Metastatic Colorectal Cancer
Q33597266A case report of apatinib in treating osteosarcoma with pulmonary metastases
Q49724049A phase II study of apatinib in patients with recurrent epithelial ovarian cancer
Q91725994A retrospective study of low-dose apatinib combined with S-1 in patients with advanced non-small cell lung cancer
Q36215991A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?
Q58547850A systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer
Q90697880An open label, multicenter, noninterventional study of apatinib in advanced gastric cancer patients (AHEAD-G202)
Q89538276Anorexia, Hypertension, Pneumothorax, and Hypothyroidism: Potential Signs of Improved Clinical Outcome Following Apatinib in Advanced Osteosarcoma
Q39067386Anti-angiogenic Therapy in Patients with Advanced Gastric and Gastroesophageal Junction Cancer: A Systematic Review
Q37225659Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer
Q90699513Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway
Q90390144Apatinib Mesylate in the treatment of advanced progressed lung adenocarcinoma patients with EGFR-TKI resistance -A Multicenter Randomized Trial
Q91739100Apatinib Monotherapy for Chemotherapy-Refractory Metastatic Colorectal Cancer: A Multi-centre, Single-Arm, Prospective Study
Q89180130Apatinib Plus Chemotherapy Shows Clinical Activity in Advanced NSCLC: A Retrospective Study
Q47728680Apatinib alone or combined with radiotherapy in metastatic prostate cancer: Results from a pilot, multicenter study.
Q57183556Apatinib as maintenance therapy in extensive-stage small-cell lung cancer: results from a single-center retrospective study
Q54977588Apatinib as targeted therapy for sarcoma.
Q90352665Apatinib combined with chemotherapy or concurrent chemo-brachytherapy in patients with recurrent or advanced cervical cancer: A phase 2, randomized controlled, prospective study
Q57111625Apatinib combined with docetaxel as a salvage treatment for metastatic esophageal squamous cancer: a case report
Q90783657Apatinib combined with oral etoposide in patients with platinum-resistant or platinum-refractory ovarian cancer (AEROC): a phase 2, single-arm, prospective study
Q47158606Apatinib concurrent gemcitabine for controlling malignant ascites in advanced pancreatic cancer patient: A case report
Q91079557Apatinib exerts anti-tumour effects on ovarian cancer cells
Q52681013Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia.
Q90594483Apatinib for Advanced Osteosarcoma after Failure of Standard Multimodal Therapy: An Open Label Phase II Clinical Trial
Q54117193Apatinib for advanced sarcoma: results from multiple institutions' off-label use in China.
Q57178943Apatinib for heavily treated patients with non-small cell lung cancer: Report of a case series and literature review
Q26775828Apatinib for molecular targeted therapy in tumor
Q58732685Apatinib for patients with advanced or recurrent cervical cancer: study protocol for an open-label randomized controlled trial
Q91676340Apatinib for treatment of a pseudomyxoma peritonei patient after surgical treatment and hyperthermic intraperitoneal chemotherapy: A case report
Q90114862Apatinib in patients with extensive-stage small-cell lung cancer after second-line or third-line chemotherapy: a phase II, single-arm, multicentre, prospective study
Q46156056Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation
Q37086246Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
Q41592916Apatinib inhibits VEGFR-2 and angiogenesis in an in vivo murine model of nasopharyngeal carcinoma
Q60950851Apatinib inhibits tumor growth and angiogenesis in PNET models
Q93143659Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer: A retrospective analysis in a real-world setting
Q47146309Apatinib is effective for treatment of advanced hepatocellular carcinoma
Q58732707Apatinib monotherapy for advanced non-small cell lung cancer after the failure of chemotherapy or other targeted therapy
Q64070319Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway
Q55383868Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Q41167283Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma
Q58779802Apatinib targets both tumor and endothelial cells in hepatocellular carcinoma
Q42289797Apatinib to combat EGFR-TKI resistance in an advanced non-small cell lung cancer patient with unknown EGFR status: a case report
Q37712356Apatinib treatment combined with chemotherapy for advanced epithelial ovarian cancer: a case report
Q64112976Apatinib treatment of advanced hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombus: A case report
Q99583852Apatinib versus sorafenib in patients with advanced hepatocellular carcinoma: a preliminary study
Q61806165Apatinib with EGFR-TKIs in advanced wild gene-type NSCLC: A case report
Q89435456Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice
Q58739900Apatinib-based targeted therapy against pulmonary sarcomatoid carcinoma: a case report and literature review
Q57287885Apatinib-induced protective autophagy and apoptosis through the AKT-mTOR pathway in anaplastic thyroid cancer
Q58790284Apatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro
Q49411843Apatinib-treated advanced medullary thyroid carcinoma: a case report
Q52583991Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers.
Q55279175Association between angiogenesis and cytotoxic signatures in the tumor microenvironment of gastric cancer.
Q52880999Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study.
Q33895597Biologic therapy in esophageal and gastric malignancies: current therapies and future directions
Q57456582Cardiovascular Toxicities with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Meta-Analysis of 77 Randomized Controlled Trials
Q91050877Changes in clinical trials of cancer drugs in mainland China over the decade 2009-18: a systematic review
Q26798288Chemotherapy beyond second-line in advanced gastric cancer
Q38604012Chemotherapy for advanced gastric cancer.
Q35288940Chemotherapy or targeted therapy as second-line treatment of advanced gastric cancer. A systematic review and meta-analysis of published studies
Q89493421Clinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer
Q34658366Clinical advances in the development of novel VEGFR2 inhibitors
Q60955467Clinical efficacy and safety of apatinib in patients with advanced colorectal cancer as the late-line treatment
Q64893996Clinical efficacy of apatinib in treating metastatic gastric cancer and its effect on IL-17.
Q42378476Clinical efficacy of endostar combined with chemotherapy in the treatment of peritoneal carcinomatosis in gastric cancer: results from a retrospective study
Q33922534Clinical impact of tumour biology in the management of gastroesophageal cancer
Q26765314Clinical modalities for management of gastric cancer hepatic metastasis
Q98386311Clinical observation of apatinib-related hypothyroidism in patients with advanced malignancies
Q41292062Clinical trials of tyrosine kinase inhibitors for lung cancer in China: a review
Q26785665Clinical utility of ramucirumab in advanced gastric cancer
Q97537942Combination of apatinib and docetaxel in treating advanced non-squamous non-small cell lung cancer patients with wild-type EGFR: a multi-center, phase II trial
Q64939558Combination of apatinib mesylate and second-line chemotherapy for treating gastroesophageal junction adenocarcinoma.
Q46832556Combined aspirin and apatinib treatment suppresses gastric cancer cell proliferation
Q89791281Combining transcatheter arterial embolization with iodized oil containing Apatinib inhibits HCC growth and metastasis
Q58759141Comparison of apatinib and capecitabine (Xeloda) with capecitabine (Xeloda) in advanced triple-negative breast cancer as third-line therapy: A retrospective study
Q58116134Comparison of efficacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human lung cancer xenograftzebrafish model
Q37536970Comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy.
Q64091227Concurrent apatinib and docetaxel vs apatinib monotherapy as third- or subsequent-line therapy for advanced gastric adenocarcinoma: a retrospective study
Q47423570Cost-Effectiveness and Budget Impact Analysis of Apatinib for Advanced Metastatic Gastric Cancer from the Perspective of Health Insurance System.
Q26801289Critical evaluation of ramucirumab in the treatment of advanced gastric and gastroesophageal cancers
Q96132801Current Molecular Targeted Agents for Advanced Gastric Cancer
Q26765941Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application
Q48117450Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial
Q40058691Early presence of anti-angiogenesis-related adverse events as a potential biomarker of antitumor efficacy in metastatic gastric cancer patients treated with apatinib: a cohort study
Q92329898Effect of Apatinib on Serum CD4+CD25+ T cells, NK Cells, and T Cells Subgroup in Malignant Tumor
Q90455818Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial
Q90529033Efficacy and safety assessment of apatinib in patients with advanced gastric cancer: a meta-analysis
Q42378852Efficacy and safety for Apatinib treatment in advanced gastric cancer: a real world study
Q42362795Efficacy and safety of Apatinib in stage IV sarcomas: experience of a major sarcoma center in China
Q28079362Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis
Q90400076Efficacy and safety of apatinib combined with chemotherapy for the treatment of advanced gastric cancer in the Chinese population: a systematic review and meta-analysis
Q47174386Efficacy and safety of apatinib combined with transarterial chemoembolization for hepatocellular carcinoma with portal venous tumor thrombus: a retrospective study
Q104686280Efficacy and safety of apatinib for the treatment of AFP-producing gastric cancer
Q64963698Efficacy and safety of apatinib in treatment of osteosarcoma after failed standard multimodal therapy: An observational study.
Q48563213Efficacy and safety of apatinib monotherapy in advanced bone and soft tissue sarcoma: An observational study
Q41430542Efficacy and safety of apatinib treatment for advanced esophageal squamous cell carcinoma
Q57071382Efficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis
Q55259389Efficacy and safety of sorafenib versus apatinib in the treatment of intermediate and advanced hepatocellular carcinoma: a comparative retrospective study.
Q52682256Efficacy and safety of targeting VEGFR drugs in treatment for advanced or metastatic gastric cancer: a systemic review and meta-analysis.
Q64256594Efficacy and toxicity of apatinib combined with or without chemotherapy for patients with advanced or metastatic chemotherapy-refractory gastric adenocarcinoma: A prospective clinical study
Q42371626Efficiency of low dosage apatinib in post-first-line treatment of advanced lung adenocarcinoma
Q35119526Establishment and characterization of patient-derived tumor xenograft using gastroscopic biopsies in gastric cancer
Q45771543Extraordinary response of metastatic pancreatic cancer to apatinib after failed chemotherapy: A case report and literature review
Q37204806Famitinib exerted powerful antitumor activity in human gastric cancer cells and xenografts
Q92551240First-line application of apatinib combined with S-1 based on peripheral circulating tumor cell screening to treat advanced gastric adenocarcinoma: a case report
Q27028079Gastric Cancer: New Drugs - New Strategies
Q39838743Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy.
Q26776195Gastric cancer: The times they are a-changin'
Q86003418Gastrointestinal cancer. Over the RAINBOW--renaissance in antiangiogenesis
Q89953612HER2/neu as target in gastric adenocarcinoma
Q41188373Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.
Q91789276Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer
Q92802225Incidence and Risk of Fatal Adverse Events in Cancer Patients Treated With Vascular Endothelial Growth Factor Receptor 2-Targeted Agents: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials
Q90299813Influence and mechanism of lung cavitation development on antiangiogenic therapy: is cavitation the new caveat?
Q36065487Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
Q98612912Large Scale, Multicenter, Prospective Study of Apatinib in Advanced Gastric Cancer: A Real-World Study from China
Q93135012Late-line treatment in metastatic gastric cancer: today and tomorrow
Q65000120Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review.
Q90429351Long-term progression-free survival of third-line apatinib in lung squamous cell carcinoma
Q60912072Merkel cell carcinoma of the thigh: case report and review of the literature
Q42957434Metastatic gastric cancer treatment: Second line and beyond
Q26798420Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy
Q34544166Multicenter phase II study of apatinib in non-triple-negative metastatic breast cancer
Q47109075Multicenter phase II study of apatinib treatment for metastatic gastric cancer after failure of second-line chemotherapy
Q26799748Multimodal treatment of gastric cancer in the west: Where are we going?
Q26738548New advances in targeted gastric cancer treatment
Q92240594Novel Agents in Heavily Pretreated Metastatic Gastric Cancer: More Shadows Than Lights
Q26786580Novel targeted agents for the treatment of lung cancer in China
Q26765208Novel targets in the treatment of advanced gastric cancer: a perspective review
Q54940671Overexpression of Kin of IRRE-Like Protein 1 (KIRREL) in Gastric Cancer and Its Clinical Prognostic Significance.
Q41091965Overwhelming rapid metabolic and structural response to apatinib in radioiodine refractory differentiated thyroid cancer
Q34326627Pathogenetic mechanisms in gastric cancer
Q64087290Phase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety
Q39630965Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors
Q90529019Progress in the treatment of solid tumors with apatinib: a systematic review
Q35541950Progression-free survival as a surrogate endpoint for overall survival in patients with third-line or later-line chemotherapy for advanced gastric cancer
Q47115888Progression-free survival of up to 8 months of an advanced intrahepatic cholangiocarcinoma patient treated with apatinib: a case report.
Q55603677Proposed Molecular and miRNA Classification of Gastric Cancer.
Q37211153Ramucirumab for the treatment of gastroesophageal cancers
Q89445769Regorafenib: lights and shadows of antiangiogenic therapies in gastric cancer
Q33816865Reply to S. Zhang, L. Fornaro et al, and H.J. Lee et al
Q48145007Reporting of health-related quality of life in randomized controlled trials involving palliative systemic therapy for esophagogastric cancer: a systematic review.
Q42317538Response to apatinib in chemotherapy-failed advanced spindle cell breast carcinoma
Q89886969Retrospective review of the activity and safety of apatinib and anlotinib in patients with advanced osteosarcoma and soft tissue sarcoma
Q94546944Role of Systemic Treatment for Advanced/Metastatic Gastric Carcinoma in the Third-Line Setting: A Bayesian Network Analysis
Q64950564Safety and Efficacy of Apatinib Combined with Temozolomide in Advanced Melanoma Patients after Conventional Treatment Failure.
Q91713198Safety and effectiveness of apatinib in patients with previously treated metastatic gastric cancer: a sub-analysis from the real-world study of apatinib for gastric cancer treatment (AHEAD-G202)
Q37725637Salvage treatment with apatinib for advanced non-small-cell lung cancer
Q30249003Second- and third-line systemic therapy in patients with advanced esophagogastric cancer: a systematic review of the literature.
Q90705312Significant Efficacy of Apatinib in a Patient With Hepatocellular Carcinoma Lung Metastases After Liver Transplantation: A Case Report
Q41915464Significant efficacy and well safety of apatinib in an advanced liver cancer patient: a case report and literature review
Q37164989Significant partial response of metastatic intra-abdominal and pelvic round cell liposarcoma to a small-molecule VEGFR-2 tyrosine kinase inhibitor apatinib: A case report
Q61809370Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report
Q50350183Successful treatment of metastatic colorectal cancer with apatinib: report of two cases and literature review
Q48563226Successful treatment using apatinib with or without docetaxel in heavily pretreated advanced non-squamous non-small cell lung cancer: A case report and literature review
Q37653025Successful treatment with apatinib for refractory recurrent malignant gliomas: a case series
Q47149532Survival benefit of anti-angiogenic agents in patients with previously treated advanced gastric or gastroesophageal junction cancer: a meta-analysis
Q92432508Survival benefits of dose-dense early postoperative intraperitoneal chemotherapy in front-line therapy for advanced ovarian cancer: a randomised controlled study
Q52576043Synergistic antitumor effects of cMet inhibitor in combination with anti-VEGF in colorectal cancer patient-derived xenograft models.
Q41644087Systemic chemotherapy as a main strategy for liver metastases from gastric cancer
Q36471685Targeted therapies in gastric cancer and future perspectives.
Q38731943Targeted therapies in gastric cancer treatment: where we are and where we are going.
Q47623942Targeted therapies: Hope for antiangiogenic therapy in advanced gastric cancer.
Q26774138Targeted therapy for advanced gastric cancer: A review of current status and future prospects
Q36294579Targeted therapy in gastroesophageal cancers: past, present and future
Q89555538TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer
Q64962531The Efficacy and Safety of Apatinib Treatment for Patients with Unresectable or Relapsed Liver Cancer: a retrospective study.
Q89538260The Impact of Ramucirumab Treatment on Survival and Quality of Life in Patients with Gastric Cancer
Q36993067The Use of Apatinib in Treating Nonsmall-Cell Lung Cancer: Case Report and Review of Literature
Q39134733The changing landscape of clinical trial and approval processes in China.
Q40539652The combinational therapy of trastuzumab and cetuximab inhibits tumor growth in a patient-derived tumor xenograft model of gastric cancer
Q55437410The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells.
Q36420167The distinct signatures of VEGF and soluble VEGFR2 increase prognostic implication in gastric cancer
Q36286390The effect of anti-angiogenic agents on overall survival in metastatic oesophago-gastric cancer: A systematic review and meta-analysis
Q93115476The effect of apatinib combined with chemotherapy or targeted therapy on non-small cell lung cancer in vitro and vivo
Q39455675The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
Q49892901The efficacy and safety of targeted therapy with or without chemotherapy in advanced gastric cancer treatment: a network meta-analysis of well-designed randomized controlled trials
Q55410948The excellent antitumor effect of apatinib alone as second-line therapy in a patient with sorafenib-refractory hepatocellular carcinoma: A case report.
Q51738099The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report.
Q33415118The role of anti-VEGF agents in the treatment of advanced gastric cancer: a meta-analysis of randomized controlled trials
Q57452863The safety and efficacy of TACE combined with apatinib on patients with advanced hepatocellular carcinoma: a retrospective study
Q92151408The use of apatinib in treating primary pleural synovial sarcoma: A case report
Q37082827Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage
Q33818002Third-line chemotherapy in advanced gastric cancer: A systematic review and meta-analysis
Q50154574Traditional Chinese medicine integrated with chemotherapy for stage IV non-surgical gastric cancer: a retrospective clinical analysis.
Q98178300Transarterial Chemoembolization Combined With Apatinib for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Q47640556Treatment of medullary thyroid carcinoma with apatinib: A case report and literature review
Q34661367Treatment options in patients with metastatic gastric cancer: current status and future perspectives
Q49283018Treatment outcome of anti-angiogenesis through VEGF-pathway in the management of gastric cancer: a systematic review of phase II and III clinical trials
Q41769227Tumor microenvironment interruption: a novel anti-cancer mechanism of Proton-pump inhibitor in gastric cancer by suppressing the release of microRNA-carrying exosomes
Q64992191Use of apatinib combined with pemetrexed for advanced ovarian cancer: A case report.
Q33432199Vorinostat in combination with capecitabine plus cisplatin as a first-line chemotherapy for patients with metastatic or unresectable gastric cancer: phase II study and biomarker analysis
Q38247980What make differences in the outcome of adjuvant treatments for resected gastric cancer?
Q37412557miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

Search more.