Efficacy generated by afatinib in a lung adenocarcinoma patient harboring HER2 S310Y mutation

scientific article published on 12 April 2018

Efficacy generated by afatinib in a lung adenocarcinoma patient harboring HER2 S310Y mutation is …
instance of (P31):
case reportQ2782326
scholarly articleQ13442814

External links are
P356DOI10.1080/15384047.2018.1449611
P932PMC publication ID5927689
P698PubMed publication ID29561699

P2093author name stringJian Wang
Lin Yang
Tengfei Zhang
Jing Liu
Lu Zhang
Peikun Ding
Guanggui Ding
Yuxin Wen
P2860cites workPotential of afatinib in the treatment of patients with HER2-positive breast cancerQ26999050
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blockerQ27681964
Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumorsQ27853154
HER2 insertion YVMA mutant lung cancer: Long natural history and response to afatinib.Q27853242
Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectivesQ28289431
Diverse somatic mutation patterns and pathway alterations in human cancersQ29619825
Treatment of metastatic extramammary Paget's disease associated with adnexal adenocarcinoma, with anti-HER2 drugs based on genomic alteration ERBB2 S310FQ34127918
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisQ34493341
Targeted therapy in NSCLC driven by HER2 insertionsQ35200528
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Q36221780
HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers.Q36423790
Activating Mutations in ERBB2 and Their Impact on Diagnostics and TreatmentQ36785721
EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.Q37021792
Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas.Q37398636
Afatinib treatment in advanced non-small cell lung cancerQ37645209
Afatinib: a review of its use in the treatment of advanced non-small cell lung cancerQ38179266
Afatinib for the treatment of advanced non-small-cell lung cancer.Q38197278
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificityQ38272701
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.Q40449400
HER2 status in lung adenocarcinoma: a comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations.Q54336136
A Rare Case of S310F Somatic ERBB2 Mutation in a HER2-Nonamplified Breast Cancer.Q55015674
Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gainsQ82448154
P433issue6
P921main subjectadenocarcinomaQ356033
P304page(s)450-453
P577publication date2018-04-12
P1433published inCancer Biology and TherapyQ2544651
P1476titleEfficacy generated by afatinib in a lung adenocarcinoma patient harboring HER2 S310Y mutation
P478volume19

Reverse relations

cites work (P2860)
Q58092149Afatinib as first-line treatment for advanced lung adenocarcinoma patients harboring HER2 mutation: A case report and review of the literature
Q60307729Clinical benefit from afatinib in an advanced squamous cell lung carcinoma patient harboring S310Y mutation: a case report
Q92068530Response to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report
Q91637215Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer
Q90206293Triple Trouble: A Case of Multiple Resistance Mechanisms after First Generation EGFR-TKI in NSCLC

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