Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation

scientific article published on 26 March 2018

Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41416-018-0050-9
P932PMC publication ID5931088
P698PubMed publication ID29576625

P2093author name stringRemco J Molenaar
Alwine B Kruisselbrink
Anne-Marie Cleton-Jansen
Judith V M G Bovée
Elisabeth F P Peterse
Yvonne de Jong
Arjen H G Cleven
Brendy E W M van den Akker
Ruben D Addie
Bertine Niessen
P2860cites workInhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.Q38884358
Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.Q38901610
Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.Q39146561
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.Q39149779
Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.Q39340562
Characterization of a new human cell line (CH-3573) derived from a grade II chondrosarcoma with matrix productionQ39393325
Mesenchymal chondrosarcoma: prognostic factors and outcome in 113 patients. A European Musculoskeletal Oncology Society studyQ41662722
Chloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbitQ41929463
Inhibitory properties of nerve-specific human glutamate dehydrogenase isozyme by chloroquineQ41941868
Targeting survivin as a potential new treatment for chondrosarcoma of boneQ42419178
Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.Q48373123
Outcome of advanced, unresectable conventional central chondrosarcoma.Q50660686
Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.Q52015949
Establishment and characterization of a continuous human chondrosarcoma cell line, ch-2879: comparative histologic and genetic studies with its tumor of origin.Q52828622
Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.Q53361172
Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma.Q54506099
Correlation of hypoxic signalling to histological grade and outcome in cartilage tumoursQ59348505
Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistanceQ82659226
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesQ24632807
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxiaQ28300406
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolismQ29617213
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
Estimated cause-specific survival continues to improve over time in patients with chondrosarcomaQ33839039
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumoursQ34186353
Characterization of a newly derived human sarcoma cell line (HT-1080).Q34202593
Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.Q34230316
Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H gliomaQ34314291
Autophagy: assays and artifactsQ34341096
Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of boneQ34396287
Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.Q34493791
The clinical approach towards chondrosarcomaQ34766148
Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 yearsQ35302545
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viabilityQ35621293
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndromeQ36190010
Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiationQ36892224
IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolismQ36948088
Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cellsQ37185828
Metformin: taking away the candy for cancer?Q37775372
Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapiesQ38165840
Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumoursQ38375735
Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapiesQ38674653
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell lineQ38746885
Prediction and validation of enzyme and transporter off-targets for metformin.Q38838317
Osteosarcoma Stem Cells Have Active Wnt/β-catenin and Overexpress SOX2 and KLF4.Q38838570
Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.Q38874166
P433issue8
P304page(s)1074-1083
P577publication date2018-03-26
P1433published inBritish Journal of CancerQ326309
P1476titleTargeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
P478volume118

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cites work (P2860)
Q100443903A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
Q61807296Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway
Q91761588Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status
Q98778655Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma
Q64972730Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes.

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