Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up

scientific article published on 27 April 2018

Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.31539
P932PMC publication ID6099282
P698PubMed publication ID29663363

P50authorRenske D. SteenbergenQ71536042
Lise M A De StrooperQ88381372
Daniëlle A M HeidemanQ90379334
Chris J L M MeijerQ90379336
Peter J F SnijdersQ90768556
P2093author name stringJohannes Berkhof
Birgit I Lissenberg-Witte
P2860cites workAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
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DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive womenQ35678378
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Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive womenQ36852263
Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-scienceQ37170521
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Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesisQ39151945
Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis.Q39815478
Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC.Q39979527
Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer.Q40202976
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Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study).Q41027688
Comparing triage algorithms using HPV DNA genotyping, HPV E7 mRNA detection and cytology in high-risk HPV DNA-positive womenQ41244440
Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions.Q41716644
Combined CADM1/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women.Q42210253
Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancerQ42245758
Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive womenQ43661461
Performance of a methylation specific real-time PCR assay as a triage test for HPV-positive women.Q43719974
Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screeningQ44876752
Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16/18: results from the ATHENA HPV studyQ46295268
Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trial.Q51201676
Primary hrHPV DNA testing in cervical cancer screening: how to manage screen-positive women? A POBASCAM trial substudy.Q51807309
CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease.Q51827467
Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer.Q54483212
Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive.Q54770367
Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trialQ61626075
Human papillomavirus DNA testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year follow-up of a randomised controlled implementation trialQ81404025
Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility studyQ82536442
Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screeningQ83603494
Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA studyQ84818275
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcervix uterine cancerQ160105
P1104number of pages8
P304page(s)1541-1548
P577publication date2018-04-27
P1433published inInternational Journal of CancerQ332492
P1476titleCervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up
P478volume143

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cites work (P2860)
Q59352587Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation
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Q89543236Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124-2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions
Q92639475Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis
Q90731036Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis
Q91752553Role of FAM19A4/miR124-2 methylation analysis in predicting regression or non-regression of CIN2/3 lesions: a protocol of an observational longitudinal cohort study
Q95856254Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma
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