Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review

scientific article published on 10 May 2018

Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3324/HAEMATOL.2017.186684
P932PMC publication ID6058775
P698PubMed publication ID29748447

P2093author name stringLuca Laurenti
Alessandra Ferrajoli
Paolo Strati
Francesco Autore
P2860cites workTP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutationsQ85068912
Overall and cancer-specific survival of patients with breast, colon, kidney, and lung cancers with and without chronic lymphocytic leukemia: a SEER population-based studyQ85938416
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelinesQ24616084
CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose TemplateQ27679016
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activationQ27851655
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemiaQ27851685
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.Q27851945
Genomic aberrations and survival in chronic lymphocytic leukemiaQ28141442
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily memberQ28268352
The cut-off levels of CD23 expression in the differential diagnosis of MCL and CLLQ28274788
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemiaQ28394721
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemiaQ29614659
Clinical staging of chronic lymphocytic leukemiaQ33337604
The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphomaQ33379107
Second cancers and Richter transformation are the leading causes of death in patients with trisomy 12 chronic lymphocytic leukemiaQ33421376
Adhesion molecules in B-chronic lymphoproliferative disordersQ33630828
The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemiaQ33655756
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutationsQ33814458
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemiaQ33873337
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.Q33956997
Relevance of stereotyped B-cell receptors in the context of the molecular, cytogenetic and clinical features of chronic lymphocytic leukemiaQ34012864
Serum levels of soluble CD23, but not soluble CD25, predict disease progression in early stage B-cell chronic lymphocytic leukemia.Q34066000
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysisQ34282319
CD23: an overlooked regulator of allergic disease.Q34662928
Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patientsQ34759512
Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemiaQ35192691
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signalingQ35208383
NOTCH1 mutations in CLL associated with trisomy 12.Q35669190
CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potentialQ35769292
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLLQ35794466
Evolution and impact of subclonal mutations in chronic lymphocytic leukemiaQ36619124
Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimensQ36900364
Complex karyotype predicts for inferior outcomes following reduced-intensity conditioning allogeneic transplant for chronic lymphocytic leukaemiaQ37036898
Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemiaQ37059754
Percentage of smudge cells on routine blood smear predicts survival in chronic lymphocytic leukemiaQ37157694
Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphomaQ37163867
Real-world clinical experience in the Connect® chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres.Q37462177
Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expressionQ37554072
Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45.Q37622532
From pathogenesis to treatment of chronic lymphocytic leukaemiaQ37643423
Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).Q37771666
Antigens in chronic lymphocytic leukemia--implications for cell origin and leukemogenesisQ37791678
A matter of debate in chronic lymphocytic leukemia: is the occurrence of autoimmune disorders an indicator of chronic lymphocytic leukemia therapy?Q37890835
ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemiaQ37980658
Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapyQ38010501
Small lymphocytic lymphoma and chronic lymphocytic leukemia: are they the same disease?Q38046044
CD49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemiaQ38848633
Mutations driving CLL and their evolution in progression and relapseQ39714436
Does IL-2 receptor expression and secretion in chronic B-cell leukemia have a role in down-regulation of the immune system?Q40804993
Clinical correlations of immunophenotypic variations and the presence of trisomy 12 in B-cell chronic lymphocytic leukemiaQ41486595
Cytogenetic and molecular cytogenetic analysis of B cell chronic lymphocytic leukemia: specific chromosome aberrations identify prognostic subgroups of patients and point to loci of candidate genesQ41493765
Trisomy 12 CLLs progress through NOTCH1 mutationsQ42537461
CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B-cell chronic lymphocytic leukaemia cellsQ42811066
Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patientsQ43555954
Late appearance of the 11q22.3-23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significanceQ43722688
Very low levels of surface CD45 reflect CLL cell fragility, are inversely correlated with trisomy 12 and are associated with increased treatment-free survivalQ44052238
B-cell receptor configuration and mutational analysis of patients with chronic lymphocytic leukaemia and trisomy 12 reveal recurrent molecular abnormalities.Q45940002
Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndromeQ46585922
Percentage of smudge cells determined on routine blood smears is a novel prognostic factor in chronic lymphocytic leukemiaQ46872563
Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemiaQ47989294
Intratumoral genetic heterogeneity and number of cytogenetic aberrations provide additional prognostic significance in chronic lymphocytic leukemia.Q48138435
FISHing in the dark: How the combination of FISH and conventional karyotyping improves the diagnostic yield in CpG-stimulated chronic lymphocytic leukemia.Q50621489
The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.Q51609722
Prognostic markers and stratification of chronic lymphocytic leukemia.Q51891213
Increased trisomy 12 frequency and a biased IgVH 3-21 gene usage characterize small lymphocytic lymphoma.Q53062744
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.Q53259951
Low CD23 expression correlates with high CD38 expression and the presence of trisomy 12 in CLL.Q53450213
Impact of trisomy 12, del(13q), del(17p), and del(11q) on the immunophenotype, DNA ploidy status, and proliferative rate of leukemic B-cells in chronic lymphocytic leukemia.Q53512382
Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations.Q54308638
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.Q54580268
Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features.Q54595876
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Q55036524
Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter SyndromeQ58001002
A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemiaQ58041425
A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidenceQ58041611
Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulinsQ58041617
Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysisQ58041632
Chronic lymphocytic leukemiaQ58042034
CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanismQ58319764
Incidence of chromosomal anomalies detected with FISH and their clinical correlations in B-chronic lymphocytic leukemiaQ58459410
The clinical and biological features of a series of immunophenotypic variant of B-CLLQ60197171
Trisomy 19 is associated with trisomy 12 and mutatedIGHVgenes in B-chronic lymphocytic leukaemiaQ60345375
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemiaQ60358460
Expression of adhesion molecules in chronic B-cell lymphoproliferative disordersQ61939597
Trisomy 12 in B-cell chronic lymphocytic leukemia: correlation with advanced disease, atypical morphology, high levels of sCD25, and with refractoriness to treatmentQ70820469
Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patientsQ71005057
The two CD23 isoforms display differential regulation in chronic lymphocytic leukaemiaQ72585155
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profileQ73023141
Clinico-prognostic implications of increased levels of soluble CD54 in the serum of B-cell chronic lymphocytic leukemia patients. Results of a multivariate survival analysisQ73397775
Cell surface expression of CD25, CD54, and CD95 on B- and T-cells in chronic lymphocytic leukaemia in relation to trisomy 12, atypical morphology and clinical courseQ74311647
Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemiaQ74628197
CD38 expression correlates with adverse biological features and predicts poor clinical outcome in B-cell chronic lymphocytic leukemiaQ77139871
Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemiaQ77637148
Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: A study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expressionQ79903978
Analysis of CD23 antigen expression in B-chronic lymphocytic leukaemia and its correlation with clinical parametersQ80467805
Molecular basis of aggressive disease in chronic lymphocytic leukemia patients with 11q deletion and trisomy 12 chromosomal abnormalitiesQ81040763
Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotypingQ81099032
Chronic lymphocytic leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ84932151
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLLQ84975869
P433issue6
P921main subjectchronic lymphocytic leukemiaQ1088156
P304page(s)931-938
P577publication date2018-05-10
P1433published inHaematologicaQ5638209
P1476titleMorphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review
P478volume103

Reverse relations

cites work (P2860)
Q90304110Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18
Q93081398Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12
Q96432059Frequency of genomic secondary findings among 21,915 eMERGE network participants