Tissue-resident memory T cells at the center of immunity to solid tumors

scientific article published on 18 May 2018

Tissue-resident memory T cells at the center of immunity to solid tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41590-018-0114-2
P698PubMed publication ID29777219

P50authorRene van LierQ44249981
Klaas Pjm van GisbergenQ62263897
Pleun HombrinkQ100729296
P2093author name stringDerk Amsen
P2860cites workCD44 cell adhesion moleculesQ24568164
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunityQ24604251
Posttranscriptional control of T cell effector function by aerobic glycolysisQ24606942
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosisQ24679720
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulationQ27317270
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Blimp-1 homolog Hobit identifies effector-type lymphocytes in humansQ28119179
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activationQ28250446
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiationQ28588268
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytesQ28588804
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cellsQ29618126
The immune contexture in human tumours: impact on clinical outcomeQ29620667
Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.Q30528857
Sensing and alarm function of resident memory CD8⁺ T cellsQ30539038
Persistence of skin-resident memory T cells within an epidermal nicheQ30576067
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CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human SkinQ33390838
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Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective functionQ33709440
Dynamic T cell migration program provides resident memory within intestinal epitheliumQ33730150
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IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.Q33769563
Mucosal imprinting of vaccine-induced CD8⁺ T cells is crucial to inhibit the growth of mucosal tumorsQ33862822
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The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.Q42259563
Tissue-resident lymphocytes: sentinel of the transformed tissueQ42350320
Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal SitesQ42380040
CD103 and Intratumoral Immune Response in Breast CancerQ42494274
Targeting latency-associated peptide promotes antitumor immunity.Q42626385
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusQ45385806
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma ImmunotherapyQ45871848
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.Q46154234
Trigger-happy resident memory CD4(+) T cells inhabit the human lungs.Q47400716
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory.Q47556615
Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responsesQ47557011
Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8+ Resident Memory T Cells in Tumors.Q47666149
Intrinsically de-sialylated CD103(+) CD8 T cells mediate beneficial anti-glioma immune responsesQ48738172
Regulation of CD8+ T Cells and Antitumor Immunity by Notch SignalingQ49222919
NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control MetastasisQ50060442
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.Q50105085
Resident Memory T Cells as Surrogate Markers of the Efficacy of Cancer Vaccines.Q50696975
CD103+ Tumor Infiltrating Lymphocytes Predict a Favorable Prognosis in Urothelial Cell Carcinoma of the Bladder.Q50747698
Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.Q50874203
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection.Q51027821
Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population.Q51985053
TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment.Q54211955
CD103+ intraepithelial lymphocytes—a unique population in microsatellite unstable sporadic colorectal cancerQ56589948
Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer PatientsQ56932510
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinomaQ58490751
Rescue of notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancerQ34017104
Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residenceQ34241501
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiationQ34245351
A central role for Notch in effector CD8(+) T cell differentiationQ34517022
T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cellsQ34626234
Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responsesQ34996288
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lungQ35015677
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infectionQ35073840
Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⁺ T cells responding to infectionQ35202406
Quantifying Memory CD8 T Cells Reveals Regionalization of ImmunosurveillanceQ35591980
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responsesQ35667029
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.Q35935558
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissuesQ35936035
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factorQ36082833
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cellsQ36129832
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cellsQ36161076
Common clonal origin of central and resident memory T cells following skin immunizationQ36246184
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.Q36258039
T-cell homing specificity and plasticity: new concepts and future challengesQ36437343
Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responsesQ36498016
Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital TractQ36535555
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian CancerQ36922131
Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infectionQ36949921
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cellsQ37352068
Homeostasis of naive and memory T cellsQ37356053
Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virusQ37412380
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell propertiesQ37439855
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell helpQ37461871
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.Q37468713
IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.Q37485997
Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma PatientsQ37492906
Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infectionQ37496801
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cellsQ37500355
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cellsQ37509860
Exploiting the curative potential of adoptive T-cell therapy for cancerQ37576033
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.Q37688907
Prognostic implications of intratumoral CD103+ tumor-infiltrating lymphocytes in pulmonary squamous cell carcinomaQ37706697
Therapeutic cancer vaccines: why so few randomised phase III studies reflect the initial optimism of phase II studiesQ37935976
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillanceQ38124438
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.Q38618945
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.Q38636573
Tissue-resident memory T cells: local specialists in immune defence.Q38674833
Cancer immune contexture and immunotherapyQ38680820
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell TherapyQ38704192
Antitumour actions of interferons: implications for cancer therapyQ38748641
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.Q38951617
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize PrimingQ38964925
Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ ProductionQ39001253
Elements of cancer immunity and the cancer-immune set pointQ39094764
The Principles of Engineering Immune Cells to Treat CancerQ39130457
Metabolic Instruction of Immunity.Q39286043
Minimal engagement of CD103 on cytotoxic T lymphocytes with an E-cadherin-Fc molecule triggers lytic granule polarization via a phospholipase Cgamma-dependent pathwayQ39609183
CD103 is a hallmark of tumor-infiltrating regulatory T cellsQ39612049
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunityQ40092134
Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacityQ40112735
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cellsQ40120388
Resident memory T cells in the skin mediate durable immunity to melanoma.Q40122403
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.Q40154614
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.Q40325436
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells.Q40476077
Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1+ Dendritic CellsQ40499828
Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage InfectionQ40499837
Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal FunctionQ40664082
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.Q40865815
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunityQ40944056
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.Q41067857
Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retentionQ41520161
T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.Q41717756
PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian CancerQ41751520
Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retentionQ41775548
Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.Q42114048
CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patientsQ42158777
Spatial map of human T cell compartmentalization and maintenance over decades of lifeQ42159822
P433issue6
P304page(s)538-546
P577publication date2018-05-18
P1433published inNature ImmunologyQ1071725
P1476titleTissue-resident memory T cells at the center of immunity to solid tumors
P478volume19

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