Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion (scientific article published on 23 May 2018)

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Role of the Collecting Duct Renin Angiotensin System in Regulation of Blood Pressure and Renal Function

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(Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H⁺-ATPase activity in MDCK.C11 collecting duct cells.

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Acute regulation of the epithelial Na+ channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells

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Non-coordinate regulation of endogenous epithelial sodium channel (ENaC) subunit expression at the apical membrane of A6 cells in response to various transporting conditions

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Elements of a paracrine tubular renin-angiotensin system along the entire nephron

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Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies

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Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4.

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The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes.

Q41935568

Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.

Q42722913

Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors

Q43964515

The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney.

Q45958088

Collecting duct (pro)renin receptor targets ENaC to mediate angiotensin II-induced hypertension

Q48056969

(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis.

Q51107556

A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron.

Q51427806

Renin and kallikrein in connecting tubule of mouse.

Q51831842

Overexpression of Renin in the collecting duct causes elevated blood pressure

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Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling

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Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

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Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention

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Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats

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(Pro)renin receptor contributes to regulation of renal epithelial sodium channel

Q30277745

Nephron-specific deletion of the prorenin receptor causes a urine concentration defect

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Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways

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Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression

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In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system

Q34242386

Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension.

Q34355942

Intratubular renin-angiotensin system in hypertension

Q34777649

The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney.

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Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone.

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AT1 receptors in the collecting duct directly modulate the concentration of urine

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Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.

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Prorenin receptor is essential for podocyte autophagy and survival

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Prorenin receptor is essential for normal podocyte structure and function

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Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system

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The collecting duct is the major source of prorenin in diabetes

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Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor

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Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production

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Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats

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Activation of ENaC in collecting duct cells by prorenin and its receptor PRR: involvement of Nox4-derived hydrogen peroxide

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Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport.

Q37139445

Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium

Q37430659

Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption.

Q37430745

Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure.

Q37629189

The biology of the (pro)renin receptor

Q37633806

P433

issue

P304

page(s)

F607-F617

P577

publication date

2018-05-23

P1433

published in

American Journal of Physiology - Renal Physiology

Q2610177

P1476

title

Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion

P478

volume

315

Reverse relations

cites work (P2860)

Q57047034	ATAC-ing the mechanisms of renin regulation
Q59792055	Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish
Q92020061	The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome
Q90836141	The (pro)renin receptor: what's in a name?