(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

scientific article published on 03 May 2018

(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41386-018-0084-Y
P932PMC publication ID6046044
P698PubMed publication ID29802366

P50authorKenji HashimotoQ70911404
P2093author name stringChun Yang
Shigeyuki Chaki
Hiroyuki Koike
Jun-Ichi Yamaguchi
Youge Qu
Akiko Mizuno-Yasuhira
Hidetoh Toki
P2860cites workR-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effectsQ28266846
Ketamine's antidepressant action: beyond NMDA receptor inhibitionQ28278684
R (-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamineQ28303539
Antidepressant effects of ketamine in depressed patientsQ29617327
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depressionQ29617914
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.Q30370600
Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammationQ34460057
Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming testQ36127598
Stereoselective and regiospecific hydroxylation of ketamine and norketamineQ36186055
Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depressionQ36233963
Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectoriesQ37424333
Drug interaction study between bupropion and ticlopidine in male CF-1 miceQ39775832
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeysQ44135052
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial samplingQ44952028
Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuitQ47306135
Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.Q47338721
Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depressionQ47403269
Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.Q47570724
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-KetamineQ47572680
Mechanistic Target of Rapamycin-Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model.Q47683691
(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.Q47822871
Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation.Q47882199
Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidineQ48251035
Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressantsQ48887628
Studies on the biotransformation of ketamine. 1-Identification of metabolites produced in vitro from rat liver microsomal preparations.Q51864897
Effects of a ketamine metabolite on synaptic NMDAR function.Q55060170
In vivo use of the CYP inhibitor 1-aminobenzotriazole to increase long-term exposure in miceQ87825044
P433issue9
P304page(s)1900-1907
P577publication date2018-05-03
P1433published inNeuropsychopharmacologyQ2261280
P1476title(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
P478volume43

Reverse relations

cites work (P2860)
Q92043421(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism
Q64111576Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?
Q60047223Is the History Repeated? Can (2R,6R)-Hydroxynorketamine be Another Antidepressant?
Q95642618Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers
Q90631290Ketamine in Major Depressive Disorder: Mechanisms and Future Perspectives
Q89548916Ketamine: Leading us into the future for development of antidepressants
Q91173369Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
Q89076158No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model
Q92873306Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
Q94954574Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
Q89923969The Effects of General Anesthetics on Synaptic Transmission
Q104509545The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

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