Reversing Mechanoinductive DSP Expression by CRISPR/dCas9-mediated Epigenome Editing

scientific article published on 01 September 2018

Reversing Mechanoinductive DSP Expression by CRISPR/dCas9-mediated Epigenome Editing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1164/RCCM.201711-2242OC
P932PMC publication ID6118013
P698PubMed publication ID29924937

P2093author name stringYong Zhou
Ping Chen
Victor J Thannickal
Jing Qu
Shuyan Liu
Morgan L Locy
Lanyan Zhu
Zijing Zhou
P2860cites workEpigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsQ22122053
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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppressionQ24627446
Matrix elasticity directs stem cell lineage specificationQ27860761
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Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndromeQ28296280
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferasesQ28587647
Super-enhancers in the control of cell identity and diseaseQ28661442
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisQ28943334
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosisQ29417118
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosisQ30274832
Functional Wnt signaling is increased in idiopathic pulmonary fibrosisQ33334369
???Q28215495
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Environment drives selection and function of enhancers controlling tissue-specific macrophage identitiesQ34452301
An atlas of active enhancers across human cell types and tissuesQ34660689
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.Q35145453
A common MUC5B promoter polymorphism and pulmonary fibrosis.Q36048530
Structural features of alveolar wall basement membrane in the adult rat lungQ36205481
Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakinQ36292214
The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammationQ36331430
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransductionQ36370200
Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigationQ36488760
Is idiopathic pulmonary fibrosis an environmental disease?Q36493941
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosisQ36638211
Host-environment interactions in pulmonary fibrosisQ36694847
Desmoplakin Variants Are Associated with Idiopathic Pulmonary FibrosisQ36916067
Repurposing the CRISPR-Cas9 system for targeted DNA methylationQ37076267
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosisQ37191868
Epigenetic cancer therapy: rationales, targets and drugsQ37969665
Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathyQ38181533
150th Anniversary Series: Desmosomes and the Hallmarks of CancerQ38541665
Editing DNA Methylation in the Mammalian GenomeQ38744151
Tunable Crosslinked Cell-Derived Extracellular Matrix Guides Cell Fate.Q38828186
Basement membrane stiffening promotes retinal endothelial activation associated with diabetes.Q38829833
Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer.Q39315240
How deeply cells feel: methods for thin gels.Q40363506
Cytoskeletal and cell adhesion defects in wounded and Pax6+/- corneal epitheliaQ42463438
Systematic identification of regulatory variants associated with cancer riskQ42653906
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous systemQ45239531
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.Q46125322
Enhanced proofreading governs CRISPR-Cas9 targeting accuracyQ46347859
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.Q46727259
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.Q47234248
Transforming growth factor-beta stimulates the expression of desmosomal proteins in bronchial epithelial cellsQ68077702
Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent mannerQ83337192
P433issue5
P921main subjectCRISPRQ412563
P304page(s)599-609
P577publication date2018-09-01
P1433published inAmerican Journal of Respiratory and Critical Care MedicineQ4744267
P1476titleReversing Mechanoinductive DSP Expression by CRISPR/dCas9-mediated Epigenome Editing
P478volume198

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cites work (P2860)
Q91692625Dead Cas Systems: Types, Principles, and Applications
Q92626279Stiff matrix instigates type I collagen biogenesis by mammalian cleavage factor I complex-mediated alternative polyadenylation
Q90131166TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

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