CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis

scientific article published on 21 June 2018

CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.97054
P932PMC publication ID6124412
P698PubMed publication ID29925681

P2093author name stringShigeki Miyamoto
Joan Heller Brown
Hal M Hoffman
Andrew Willeford
Audrey Nickle
Takeshi Suetomi
P2860cites workCaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.Q46615618
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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.Q51072106
S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury.Q54214133
CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure OverloadQ58003417
Isolation and culture of adult mouse cardiac myocytesQ64377366
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Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivoQ79967267
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Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.Q27340146
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CaMKII determines mitochondrial stress responses in heartQ28591986
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A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidationQ29620430
Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction.Q33660939
Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin IIQ34264496
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The cardiokine story unfolds: ischemic stress-induced protein secretion in the heartQ34809985
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.Q34833218
CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injuryQ34880308
Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensationQ35132584
CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosisQ35159918
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.Q35621283
Up-regulated TLR4 in cardiomyocytes exacerbates heart failure after long-term myocardial infarctionQ35750924
Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the MouseQ35847003
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.Q35903753
Angiotensin II revisited: new roles in inflammation, immunology and agingQ36039299
Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo.Q36142000
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart FailureQ36261243
Temporal neutrophil polarization following myocardial infarctionQ36702435
Macrophage activation by endogenous danger signalsQ37045743
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of CardiologyQ37090971
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heartQ37143342
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.Q37170829
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.Q37363053
Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload.Q37434655
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasomeQ37453447
Endoplasmic reticulum stress in bone marrow-derived cells prevents acute cardiac inflammation and injury in response to angiotensin II.Q37482793
PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2.Q37534751
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammationQ37581780
Mechanisms of cardiac fibrosis in inflammatory heart disease.Q37743971
Emerging role of damage-associated molecular patterns derived from mitochondria in inflammationQ37844960
Innate immune signaling in cardiac ischemiaQ37859249
Fibrosis and heart failureQ38057701
Danger signals in the initiation of the inflammatory response after myocardial infarctionQ38173348
Myocyte signalling in leucocyte recruitment to the heartQ38185647
The inflammasome in myocardial injury and cardiac remodelingQ38261433
Complexity of danger: the diverse nature of damage-associated molecular patterns.Q38267715
Inflammation in cardiac injury, repair and regeneration.Q38390454
Role of inflammatory cells in fibroblast activationQ38643076
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis.Q38875774
Chronic Heart Failure and Inflammation: What Do We Really Know?Q38875783
Mechanism and Regulation of NLRP3 Inflammasome ActivationQ38964695
CaMKII is a nodal signal for multiple programmed cell death pathways in heartQ39056528
ASC speck formation as a readout for inflammasome activationQ39126034
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.Q40385305
The Cardiomyocyte as a Source of Cytokines in Cardiac InjuryQ41256651
TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosisQ41324289
Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB.Q41584910
Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling.Q41873666
Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activationQ41914695
Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophyQ42097897
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.Q42114357
Optimized dosing of a CCR2 antagonist for amplification of vaccine immunityQ42771123
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in miceQ44196757
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouseQ45027851
Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failureQ45103986
Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblastsQ46046832
Complement-induced activation of the cardiac NLRP3 inflammasome in sepsisQ46499624
P4510describes a project that usesImageJQ1659584
P433issue12
P577publication date2018-06-21
P1433published inJCI insightQ27727187
P1476titleCaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis
P478volume3

Reverse relations

cites work (P2860)
Q91259754Autophagy and cardiac aging
Q91959121Ca2+/Calmodulin-dependent kinase II delta B is essential for cardiomyocyte hypertrophy and complement gene expression after LPS and HSP60 stimulation in vitro
Q93140729CaMKII Activity in the Inflammatory Response of Cardiac Diseases
Q91003117CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy
Q91722872Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts
Q96166983NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases
Q91816034Postoperative atrial fibrillation: mechanisms, manifestations and management
Q97637714The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

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