Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis

scientific article published on 20 June 2018

Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41401-018-0007-9
P932PMC publication ID6289325
P698PubMed publication ID29925920

P50authorKexiong ZhangQ40021238
P2093author name stringYa Liu
Yao Shi
Ying-Ying Liu
Xing-Hua Pan
P2860cites workTelomerase modulates Wnt signalling by association with target gene chromatinQ24310084
The telomere syndromesQ24632444
Alveolar epithelial type II cell: defender of the alveolus revisitedQ24791750
When stem cells grow old: phenotypes and mechanisms of stem cell agingQ26770845
Changing the idiopathic pulmonary fibrosis treatment approach and improving patient outcomesQ26859044
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespanQ28005547
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersQ28252088
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injuryQ28504566
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisQ28943334
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
Telomerase mutations in families with idiopathic pulmonary fibrosisQ29615671
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental programQ33315569
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutationsQ33587591
Telomerase deficiency does not alter bleomycin-induced fibrosis in miceQ33714052
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.Q33877362
Telomerase activity in normal and malignant hematopoietic cellsQ33883794
Inflammatory networks during cellular senescence: causes and consequencesQ33889156
Incidence and prevalence of idiopathic pulmonary fibrosisQ33997249
Four faces of cellular senescence.Q34025754
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in miceQ34045591
ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosisQ34537989
Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosisQ35010171
Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth responseQ35057063
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycinQ35085416
Idiopathic pulmonary fibrosis: update on genetic discoveriesQ35092480
Telomerase activity in human germline and embryonic tissues and cells.Q49024139
IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.Q51687384
Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation.Q51688171
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.Q52617872
Relationship between mammalian target of rapamycin and autophagy in lipopolysaccharide-induced lung injury.Q54204696
Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.Q54261111
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.Q54446398
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient MiceQ56508064
Idiopathic pulmonary fibrosisQ56764887
Early-Onset Inflammatory ResponsesIn Vivoto Adenoviral Vectors in the Presence or Absence of Lipopolysaccharide-Induced InflammationQ56960180
Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammationQ77569805
Decreased alveolar oxygen induces lung inflammationQ78396790
Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsisQ79156239
Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell functionQ83344193
Telomere dysfunction causes alveolar stem cell failureQ35549158
RGD-tagged helical rosette nanotubes aggravate acute lipopolysaccharide-induced lung inflammation.Q35662217
Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosisQ35850237
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient miceQ35855163
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosisQ35863725
Inflammasome-regulated cytokines are critical mediators of acute lung injuryQ36026253
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.Q36407242
A new development in senescenceQ36433786
Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in miceQ36591501
Short telomeres are a risk factor for idiopathic pulmonary fibrosisQ36861819
Telomere shortening in familial and sporadic pulmonary fibrosisQ36915503
Type 2 alveolar cells are stem cells in adult lung.Q36966911
Molecular targets in pulmonary fibrosis: the myofibroblast in focus.Q36969931
Lung alveolar integrity is compromised by telomere shortening in telomerase-null miceQ37086294
Senescence at a glanceQ37168870
Immunodesign of experimental sepsis by cecal ligation and punctureQ37368111
The pathogenesis of idiopathic pulmonary fibrosis.Q37800756
Viral infection and aging as cofactors for the development of pulmonary fibrosisQ37815487
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.Q37880150
Diverse roles of TGF-β/Smads in renal fibrosis and inflammationQ37934555
TGF-β/Smad signaling in kidney disease.Q38029818
Molecular mechanisms of regulated necrosisQ38192325
hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanismsQ39390523
Analysis of cellular senescence induced by lipopolysaccharide in pulmonary alveolar epithelial cells.Q39483639
Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blotQ39552773
ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responsesQ39766332
NF-κB inhibition delays DNA damage-induced senescence and aging in miceQ42220488
Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunctionQ42740080
Biphasic effects of selective inhibition of transforming growth factor beta1 activin receptor-like kinase on LPS-induced lung injuryQ43187310
Inhibition of activin receptor-like kinase 5 induces matrix metallopeptidase 9 expression and aggravates lipopolysaccharide-induced pulmonary injury in miceQ43952880
Neutrophils play a critical role in development of LPS-induced airway diseaseQ44176949
Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation.Q47829848
Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expressionQ47877799
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injuryQ47926105
Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injuryQ48105507
Introduction of antisense oligonucleotides to heat shock protein 47 prevents pulmonary fibrosis in lipopolysaccharide-induced pneumopathy of the rat.Q48222101
P4510describes a project that usesImageJQ1659584
P433issue11
P921main subjectpulmonary fibrosisQ32446
lipopolysaccharideQ421804
P304page(s)1735-1745
P577publication date2018-06-20
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleTelomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis
P478volume39

Reverse relations

cites work (P2860)
Q92701873Telomere Abnormalities in the Pathobiology of Idiopathic Pulmonary Fibrosis
Q93082066The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications
Q99550259[Role of microRNA-17-5p in the pathogenesis of pediatric nephrotic syndrome and related mechanisms]

Search more.