Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle-centering mechanism

scientific article published on 25 June 2018

Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle-centering mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201804166
P932PMC publication ID6122980
P698PubMed publication ID29941476

P50authorViji M. DraviamQ83955923
Ihsan N ZulkipliQ85452129
Roshan L ShresthaQ89239872
Izabela KujawiakQ89239875
Nishanth SastryQ57446873
P2093author name stringDavid Dang
Joanna Clark
Madeleine Hart
Parveen Gul
Tami Kasichiwin
P2860cites workCortical dynein is critical for proper spindle positioning in human cellsQ24300064
Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neuronsQ24306132
Aurora B regulates MCAK at the mitotic centromereQ24307822
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262Q24313123
The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cellsQ24313178
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruptionQ24313701
MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosisQ24319920
Epithelial homeostasisQ26864115
Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytesQ27316277
Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cellsQ27332112
Mechanism for astral microtubule capture by cortical Bud6p priming spindle polarity in S. cerevisiae.Q27930519
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachmentsQ28236606
Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamicsQ28278995
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning PredictionsQ28550159
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientationQ29871463
Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashionQ30477500
Molecular requirements for kinetochore-associated microtubule formation in mammalian cellsQ30477572
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent mannerQ30479119
Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cellsQ30481432
Dual role of Cdc42 in spindle orientation control of adherent cellsQ30487617
Finding the cell center by a balance of dynein and myosin pulling and microtubule pushing: a computational studyQ30497659
Regulated offloading of cytoplasmic dynein from microtubule plus ends to the cortexQ30500353
Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule astersQ30506063
Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioningQ73086391
ABL1 regulates spindle orientation in adherent cells and mammalian skin.Q30512982
Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientationQ30525035
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenanceQ30559683
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomesQ30582170
Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cellsQ30583150
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammalsQ33327076
Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioningQ33578600
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachmentQ34267263
A model for cleavage plane determination in early amphibian and fish embryosQ34540517
Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosisQ34738625
A novel mechanism of microtubule length-dependent force to pull centrosomes toward the cell centerQ35172271
Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosisQ35276904
MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membraneQ35389287
High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes.Q35552502
Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation.Q36146717
Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphaseQ36202736
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeletonQ36322073
The Par-1/MARK family of protein kinases: from polarity to metabolismQ36919801
MCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics.Q37127270
Spindle orientation and epidermal morphogenesisQ37204606
Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transitionQ37289381
Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.Q38066193
Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growthQ39484983
Kindlin1 regulates microtubule function to ensure normal mitosisQ39906864
Cytokeratin patterns of expression in human epithelial cell lines correlate with transcriptional activity of the human papillomavirus type 16 upstream regulatory regionQ41066994
The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.Q41069471
Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.Q41445584
A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset.Q42175728
Growing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axisQ42264164
Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancersQ42632502
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axonsQ42916183
The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior poleQ47071128
Cortical capture of microtubules and spindle polarity in budding yeast - where's the catch?Q48955209
PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.Q51970435
EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways.Q52174453
A force-generating machinery maintains the spindle at the cell center during mitosis.Q52867200
LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning.Q53510991
P433issue9
P1104number of pages14
P304page(s)3057-3070
P577publication date2018-06-25
P1433published inJournal of Cell BiologyQ1524550
P1476titleSpindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle-centering mechanism
P478volume217

Reverse relations

cites work (P2860)
Q83225300Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation
Q93019680MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly

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