Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo

scientific article published on 29 June 2018

Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00432-018-2696-3
P698PubMed publication ID29959569

P50authorFrancesco MaramponQ39185685
Annunziata MauroQ59682742
Marina BouchéQ59691899
P2093author name stringPaolo Berardinelli
Claudio Festuccia
Giovanni Luca Gravina
Vincenzo Tombolini
Daniela Musio
Francesca De Felice
Andrea Del Fattore
Bianca Maria Zani
Carmela Ciccarelli
Agnese Di Rocco
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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesisQ35207795
Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cellsQ35579329
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c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.Q38776254
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KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approachQ38849399
Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model.Q38857929
Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay.Q39010806
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PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90, and CRM1 in preclinical models of prostate cancerQ39178894
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Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors.Q40245452
Myc confers androgen-independent prostate cancer cell growthQ40271517
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Discovery of a selective irreversible BMX inhibitor for prostate cancer.Q42711869
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Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.Q47848908
Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion.Q52575009
Immortalization of primary human prostate epithelial cells by c-Myc.Q53359625
Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapyQ57790286
Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasiaQ68952062
Detection of chromosomal anomalies and c-myc gene amplification in the cribriform pattern of prostatic intraepithelial neoplasia and carcinoma by fluorescence in situ hybridizationQ73919482
P433issue9
P304page(s)1685-1699
P577publication date2018-06-29
P1433published inJournal of Cancer Research and Clinical OncologyQ2081599
P1476titleDisruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo
P478volume144

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cites work (P2860)
Q64951143Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation.
Q98158987Dual effects of active ERK in cancer: A potential target for enhancing radiosensitivity
Q64266350HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells
Q92243738IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway
Q92134426KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma

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