Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

scientific article published on 30 January 2020

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JCMM.15026
P932PMC publication ID7131910
P698PubMed publication ID32000299

P50authorShi-Jie ZhangQ88190691
P2093author name stringQi Wang
Xiao-Qi Liu
Tian Hu
Yun-Bo Chen
Xin-Yi Lu
Jing-Jing Shi
Qu-Bo Chen
P2860cites workBiochemical effects of SIRT1 activatorsQ24633830
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Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berriesQ34508570
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionQ34534198
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The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose TissueQ36279200
Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathwayQ36410706
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Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse VasculitisQ37620412
The inflammasomes in kidney diseaseQ37874866
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Autoinflammation and autoimmunity: bridging the divide.Q38033406
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neuronsQ38543012
Proliferative Properties of 17β-aminoestrogens in MCF-7 Human Breast Cancer Cells.Q38745892
The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes modelQ38844106
Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathyQ39003277
Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic ratsQ39155883
Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.Q39351131
Neuroactive steroids and diabetic complications in the nervous system.Q39455313
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.Q40694285
Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury ModelQ40941919
Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection.Q41192250
Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed ratsQ42707016
Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of ratsQ42713198
Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male ratsQ42713561
Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries studyQ43885250
Sirt1 regulates aging and resistance to oxidative stress in the heartQ44830459
Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Q44897378
Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1.Q46236638
Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell LinesQ46399998
Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injuryQ46612218
Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stressQ47372651
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db MiceQ47939966
Anti-inflammatory effects of flavonoids in neurodegenerative disorders.Q47965744
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy inductionQ47981400
Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.Q48146151
Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats.Q48153937
Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic ratsQ48254377
Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesisQ48404189
Role of angiotensin II in the brain inflammatory events during experimental diabetes in ratsQ48589533
Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 InflammasomeQ50175498
Maternal quercetin administration during gestation and lactation decrease endoplasmic reticulum stress and related inflammation in the adult offspring of obese female rats.Q51158217
SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells.Q51582475
Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences.Q51971957
Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.Q52672952
Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cellsQ58586873
Cardiovascular risk factors and cognitive decline in middle-aged adultsQ60692491
Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse BrainQ60960128
Type 2 diabetes and cognitive impairmentQ78766613
Prevalence of other diabetes-associated complications and comorbidities and its impact on health care charges among patients with diabetic neuropathyQ79637538
Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosidesQ81119441
Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistanceQ83069122
Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanismsQ84016180
Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1Q89151888
Senolytics improve physical function and increase lifespan in old ageQ89486364
NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosisQ90398382
Morphological and Pathological Characteristics of Brain in Diabetic EncephalopathyQ90442029
Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic ratsQ90655613
Glucose area under the curve during oral glucose tolerance test as an index of glucose intoleranceQ90856455
P921main subjectdiabetic encephalopathyQ18553513
P577publication date2020-01-30
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleQuercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Reverse relations

Q125244629Quercetin modulates expression of serum exosomal long noncoding RNA NEAT1 to regulate the miR-129-5p/BDNF axis and attenuate cognitive impairment in diabetic micecites workP2860

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