Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation

scientific article published on 05 July 2018

Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLCEL.2018.06.001
P932PMC publication ID6086580
P698PubMed publication ID29983320

P2093author name stringQi Liu
Jack W Szostak
Junho Choe
Richard I Gregory
Shuibin Lin
Victor S Lelyveld
P2860cites workDo all modifications benefit all tRNAs?Q37479913
Post-transcriptional gene regulation by mRNA modifications.Q37515917
Role of tRNA modifications in human diseasesQ38192152
Emerging roles of tRNA in adaptive translation, signalling dynamics and diseaseQ38298151
Further delineation of the phenotype caused by biallelic variants in the WDR4 geneQ41919459
tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8pQ42278299
Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational RegulationQ47337711
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.Q47352505
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.Q51534536
Rapid tRNA decay can result from lack of nonessential modifications.Q54342180
Tertiary structure interactions of 7-methylguanosine in yeast tRNA Phe as studied by borohydride reductionQ67481520
Specific fragmentation of tRNA and rRNA at a 7-methylguanine residue in the presence of methylated carrier RNAQ69381068
Ultrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusionsQ21999527
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cellsQ24301036
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.Q24313644
GENCODE: the reference human genome annotation for The ENCODE ProjectQ24608743
Multiplex genome engineering using CRISPR/Cas systemsQ24609428
The crystal structure of yeast phenylalanine tRNA at 2.0 A resolution: cleavage by Mg(2+) in 15-year old crystalsQ27625843
Structure of the yeast tRNA m7G methylation complexQ27649501
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.Q27938848
Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat proteinQ28144220
Loss of a conserved tRNA anticodon modification perturbs cellular signalingQ28535022
ALKBH1-Mediated tRNA Demethylation Regulates TranslationQ28590996
HTSeq--a Python framework to work with high-throughput sequencing dataQ29614489
Compilation of tRNA sequences and sequences of tRNA genesQ29615891
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monocultureQ29616806
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cellsQ34214788
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer CellsQ34523745
Identification of small molecule inhibitors of Zcchc11 TUTase activityQ35675564
Efficient and quantitative high-throughput tRNA sequencing.Q35715852
ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragmentsQ35734958
Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome IntegrityQ35855945
Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfismQ36105008
GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomesQ36434994
The many applications of acid urea polyacrylamide gel electrophoresis to studies of tRNAs and aminoacyl-tRNA synthetasesQ36513905
Analysis of aminoacyl- and peptidyl-tRNAs by gel electrophoresisQ36928542
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndromeQ37423613
P433issue2
P921main subjectstem cell self-renewalQ107637617
P304page(s)244-255.e5
P577publication date2018-07-05
P1433published inMolecular CellQ3319468
P1476titleMettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation
P478volume71

Reverse relations

cites work (P2860)
Q609516987-Methylguanosine Modifications in Transfer RNA (tRNA)
Q94564068Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma
Q61449486Codon-Specific Translation by mG37 Methylation of tRNA
Q93080003Comparative Analysis of MicroRNA and mRNA Profiles of Sperm with Different Freeze Tolerance Capacities in Boar (Sus scrofa) and Giant Panda (Ailuropoda melanoleuca)
Q93086724Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome
Q90029388Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing
Q94546007Direct activation of tRNA methyltransferase-like 1 (Mettl1) gene by thyroid hormone receptor implicates a role in adult intestinal stem cell development and proliferation during Xenopus tropicalis metamorphosis
Q91844964Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis
Q90101476Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation
Q90626546Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology
Q89710826Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
Q91577900METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation
Q61799430Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies
Q90066316Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis
Q91753653Multilevel defects in the hematopoietic niche in essential thrombocythemia
Q91763636N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
Q92600798N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer
Q90754874Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq
Q92350973Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
Q92186109Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis
Q98155076Prediction of N7-methylguanosine sites in human RNA based on optimal sequence features
Q90468329RNA-modifying enzymes and their function in a chromatin context
Q92420300RNAmod: an integrated system for the annotation of mRNA modifications
Q95839913The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis
Q102059167The epitranscriptome beyond m6A
Q92717031TrmB, a tRNA m7G46 methyltransferase, plays a role in hydrogen peroxide resistance and positively modulates the translation of katA and katB mRNAs in Pseudomonas aeruginosa

Search more.