Chlamydomonas reinhardtii as a plant model system to study mitochondrial complex I dysfunction

scientific article published on 03 February 2020

Chlamydomonas reinhardtii as a plant model system to study mitochondrial complex I dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PLD3.200
P932PMC publication ID6996877
P698PubMed publication ID32025618

P2093author name stringNitya Subrahmanian
Patrice Paul Hamel
Thea Aspelund Fatnes
Andrew David Castonguay
P2860cites workNDUFB7 and NDUFA8 are located at the intermembrane surface of complex IQ24292839
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathyQ24302105
C6ORF66 is an assembly factor of mitochondrial complex IQ24305552
Mitochondrial disorders in children: toward development of small-molecule treatment strategiesQ26767327
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathwayQ27931352
A mitochondrial RNA maturase gene transferred to the yeast nucleus can control mitochondrial mRNA splicingQ27936770
Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondriaQ27938029
Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative DiseasesQ28069775
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
The nuclear encoded subunits of complex I from bovine heart mitochondriaQ28183992
Mutants of Chlamydomonas reinhardtii deficient in mitochondrial complex I: characterization of two mutations affecting the nd1 coding sequenceQ28343957
A study on the effect of surface lysine to arginine mutagenesis on protein stability and structure using green fluorescent proteinQ28481191
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanismQ29616055
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active formQ29619372
Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complexQ31135188
Accessory subunits are integral for assembly and function of human mitochondrial complex I.Q32884468
Mitochondrial NADH:ubiquinone oxidoreductase (complex I) in eukaryotes: a highly conserved subunit composition highlighted by mining of protein databasesQ34199841
Higher plant-like subunit composition of mitochondrial complex I from Chlamydomonas reinhardtii: 31 conserved components among eukaryotesQ34353422
Nuclear genetic defects of oxidative phosphorylationQ34416723
Structure of bacterial respiratory complex I.Q51552650
Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population.Q51658567
Efficient isolation and mapping of Arabidopsis thaliana T-DNA insert junctions by thermal asymmetric interlaced PCR.Q54164416
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined statesQ56559238
Cryo-EM structure of respiratory complex I at workQ57045684
Human diseases associated with defects in assembly of OXPHOS complexesQ57175222
Application of the obligate aerobic yeast Yarrowia lipolytica as a eucaryotic model to analyse Leigh syndrome mutations in the complex I core subunits PSST and TYKYQ58782665
Classical mitochondrial phenotypes without mtDNA mutations: The possible role of nuclear genesQ61797337
Long range control circuits within mitochondria and between nucleus and mitochondria. I. Methodology and phenomenology of suppressorsQ67248033
The Chlamydomonas Sourcebook. A Comprehensive Guide to Biology and Laboratory Use. Elizabeth H. Harris. Academic Press, San Diego, CA, 1989. xiv, 780 pp., illus. $145Q80952365
Pathogenic mutations in NUBPL affect complex I activity and cold tolerance in the yeast model Yarrowia lipolyticaQ89457267
Mammalian Mitochondrial Complex I Structure and Disease-Causing MutationsQ90589438
Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational CrosstalkQ93160398
High-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genesQ34574990
High-efficiency transformation of Chlamydomonas reinhardtii by electroporationQ34603847
The mitochondrial electron transfer chainQ34697908
A forward genetic screen identifies mutants deficient for mitochondrial complex I assembly in Chlamydomonas reinhardtii.Q35065469
High-Throughput Genotyping of Green Algal Mutants Reveals Random Distribution of Mutagenic Insertion Sites and Endonucleolytic Cleavage of Transforming DNA.Q35140604
Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson's diseaseQ35240670
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapiesQ35687142
Application of the yeast Yarrowia lipolytica as a model to analyse human pathogenic mutations in mitochondrial complex I (NADH:ubiquinone oxidoreductase).Q35970225
Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignmentsQ36120239
Mitochondrial respiratory complex I: structure, function and implication in human diseasesQ36444688
Complementation of a Chlamydomonas reinhardtii mutant using a genomic cosmid libraryQ36743948
The three families of respiratory NADH dehydrogenasesQ36827215
Human mitochondrial complex I assembly: a dynamic and versatile processQ36940191
Eukaryotic complex I: functional diversity and experimental systems to unravel the assembly processQ37194604
Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.Q37428322
Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potentialQ37502598
Mitochondrial complex I deficiency of nuclear origin I. Structural genesQ37964862
Mitochondrial complex I.Q38092859
Accessory subunits of mitochondrial complex I.Q38141073
Respiratory-deficient mutants of the unicellular green alga Chlamydomonas: a reviewQ38153971
Three approaches to one problem: protein folding in the periplasm, the endoplasmic reticulum, and the intermembrane spaceQ38183879
Plant mitochondrial Complex I composition and assembly: A reviewQ38708399
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.Q38741912
Isolation of Chlamydomonas reinhardtii mutants with altered mitochondrial respiration by chlorophyll fluorescence measurementQ40891935
Structure of mammalian respiratory complex IQ41121933
Architecture of mammalian respiratory complex I.Q41607512
Neurospora strains harboring mitochondrial disease-associated mutations in iron-sulfur subunits of complex I.Q42708849
Sequence variation in mitochondrial complex I genes: mutation or polymorphism?Q43170644
Mutations inactivating mitochondrial genes in Chlamydomonas reinhardtiiQ43702698
Impact of mutations affecting ND mitochondria-encoded subunits on the activity and assembly of complex I in Chlamydomonas. Implication for the structural organization of the enzymeQ44038167
Photosynthesis and state transitions in mitochondrial mutants of Chlamydomonas reinhardtii affected in respirationQ44664120
Functional genomics of eukaryotic photosynthesis using insertional mutagenesis of Chlamydomonas reinhardtii.Q45969865
Mitochondrial complex I-linked diseaseQ46591466
In vivo chlorophyll fluorescence screening allows the isolation of a Chlamydomonas mutant defective for NDUFAF3, an assembly factor involved in mitochondrial complex I assemblyQ47787889
Impact of a mutation in the mitochondrial LSU rRNA gene from Chlamydomonas reinhardtii on the activity and the assembly of respiratory-chain complexesQ47967222
Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly.Q48008156
Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndromeQ48160532
Characterization of an internal type-II NADH dehydrogenase from Chlamydomonas reinhardtii mitochondria.Q50493348
Reconstruction of a human mitochondrial complex I mutation in the unicellular green alga Chlamydomonas.Q50503815
In Chlamydomonas, the loss of ND5 subunit prevents the assembly of whole mitochondrial complex I and leads to the formation of a low abundant 700 kDa subcomplex.Q50647154
P433issue2
P921main subjectChlamydomonas reinhardtiiQ291827
P304page(s)e00200
P577publication date2020-02-03
P1433published inPlant DirectQ73379286
P1476titleChlamydomonas reinhardtii as a plant model system to study mitochondrial complex I dysfunction
P478volume4

Reverse relations

Q89789479Assembly of Mitochondrial Complex I Requires the Low-Complexity Protein AMC1 in Chlamydomonas reinhardtiicites workP2860

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