Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer

scientific article published on 12 July 2018

Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JCMM.13752
P932PMC publication ID6156240
P698PubMed publication ID29999571

P50authorTao WenQ64913488
P2093author name stringLei Yang
Jian Liu
Haili Qian
Zhe Liu
Feng Xu
Guangyu An
Yuliang Jiang
Xingyuan Jia
Tianbo Gao
Xichen Dong
Yurong Cheng
Yizhang Hu
P2860cites workCloning and expression of human core 1 beta1,3-galactosyltransferaseQ24291836
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycansQ24292241
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in miceQ24295254
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferaseQ24543917
Mucins in cancer: function, prognosis and therapyQ24633765
Roles of the gel-forming MUC2 mucin and its O-glycosylation in the protection against colitis and colorectal cancerQ26995226
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin VQ28294206
Cosmc is an essential chaperone for correct protein O-glycosylationQ28506209
Colorectal cancer in mice genetically deficient in the mucin Muc2Q28588769
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactionsQ29617847
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionQ29618129
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosaQ33582232
The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthaseQ33593911
Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling.Q33918398
Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.Q33934190
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.Q34035601
Immature truncated O-glycophenotype of cancer directly induces oncogenic featuresQ34314283
A novel fluorescent assay for T-synthase activityQ34552242
Colorectal cancer statistics, 2017.Q34552373
NF-kappaB protects human papillomavirus type 38 E6/E7-immortalized human keratinocytes against tumor necrosis factor alpha and UV-mediated apoptosis.Q35193057
Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.Q35865937
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in MiceQ35983991
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycansQ36229430
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigenQ36436153
Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness.Q37117895
Loss of intestinal O-glycans promotes spontaneous duodenal tumorsQ37139510
Carbohydrate markers in colon carcinomaQ37363702
Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.Q37534378
Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigenQ37552405
The Tn antigen-structural simplicity and biological complexityQ37831859
The Cosmc connection to the Tn antigen in cancerQ38197051
Glycosylation in cancer: mechanisms and clinical implicationsQ38569702
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.Q38869978
Cancer Statistics, 2017.Q39038674
Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymesQ39700918
Human tumor antigens Tn and sialyl Tn arise from mutations in CosmcQ40002603
Cancer statistics in China, 2015.Q40064386
A mutant chaperone converts a wild-type protein into a tumor-specific antigenQ40220542
The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.Q44392892
Expression of Tn, sialosyl-Tn, and T antigens in human colon cancerQ44572570
Protein glycosylation: chaperone mutation in Tn syndromeQ46776454
Expression of Tn, sialosyl Tn, and T antigens in human pancreasQ46842675
Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in miceQ48365705
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.Q51767552
Carbohydrate expression profile of colorectal cancer cells is relevant to metastatic pattern and prognosis.Q52842975
Helix pomatia agglutinin binding is a useful prognostic indicator in colorectal carcinomaQ57222452
O-linked mucin-type glycoproteins in normal and malignant colon mucosa: lack of T-antigen expression and accumulation of Tn and sialosyl-Tn antigens in carcinomasQ68749979
Blood group MN specific substances and precursors in normal and malignant human breast tissuesQ68802187
Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human seraQ70077073
Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: relationship with histopathology and prognosisQ73622361
Expression of sialyl-Tn, Tn and T antigens in primary liver cancerQ77872186
P433issue10
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)4875-4885
P577publication date2018-07-12
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleAberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer
P478volume22

Reverse relations

cites work (P2860)
Q89782685A Systematic Review on the Implications of O-linked Glycan Branching and Truncating Enzymes on Cancer Progression and Metastasis
Q98224783Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics
Q90217150Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44
Q89908247Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens
Q95839861Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans
Q64249139Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation

Search more.