Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

scientific article published on 07 February 2020

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism is …
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scholarly articleQ13442814

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P356DOI10.1073/PNAS.1920202117
P932PMC publication ID7049152
P698PubMed publication ID32034094

P50authorMichael PlougQ39427971
Haydyn D MertensQ58205910
Gabriel BirraneQ59611108
Thomas J.D. JørgensenQ63412829
P2093author name stringStephen G Young
Gunilla Olivecrona
Katrine Zinck Leth-Espensen
Kristian K Kristensen
Muthuraman Meiyappan
P2860cites workGPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesQ24338437
GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4Q24338849
The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanismsQ28118447
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissueQ28272732
Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formationQ28296885
Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodiesQ28624276
Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domainQ33888534
Lipoprotein lipase domain function.Q34338487
EX1 hydrogen exchange and protein foldingQ35632716
Lipase maturation factor 1: a lipase chaperone involved in lipid metabolismQ35784094
A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipaseQ36151990
The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.Q36585939
Biochemistry and pathophysiology of intravascular and intracellular lipolysisQ36708030
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary DiseaseQ36851336
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery DiseaseQ36988623
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.Q37036119
Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectraQ37373776
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride MetabolismQ91586192
Structure of lipoprotein lipase in complex with GPIHBP1Q91897805
New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease riskQ92503344
Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?Q92510521
Endoplasmic reticulum quality control in lipoprotein metabolismQ92818571
Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in HypertriglyceridemiaQ93049588
Calcium triggers folding of lipoprotein lipase into active dimersQ38320722
Chylomicronaemia--current diagnosis and future therapiesQ38366873
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.Q38729657
An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.Q38805219
GPIHBP1 and Plasma Triglyceride MetabolismQ38835828
Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseasesQ38988355
The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillariesQ39004975
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary diseaseQ39804212
ANGPTL3 Deficiency and Protection Against Coronary Artery DiseaseQ40254292
Apolipoprotein cii enhances hydrolysis of monoglycerides by lipoprotein lipase, but the effect is abolished by fatty acidsQ40266894
GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding.Q41877871
A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.Q42178295
Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipaseQ42184230
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.Q42355233
Autoantibodies against GPIHBP1 as a Cause of HypertriglyceridemiaQ42535148
Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysisQ42612557
Rapid subunit exchange in dimeric lipoprotein lipase and properties of the inactive monomerQ45072791
Phospholipase activity of milk lipoprotein lipaseQ45236292
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.Q46503166
We FRET so You Don't Have To: New Models of the Lipoprotein Lipase DimerQ47206557
An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum.Q47288042
Angiopoietin-like 3 in lipoprotein metabolismQ47688043
Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.Q51512763
Studies on inactivation of lipoprotein lipase: role of the dimer to monomer dissociation.Q52661682
Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase.Q54005021
Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activityQ57840170
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysisQ61990260
Lipoprotein lipase is active as a monomerQ64118093
Detection and characterization of the heterozygote state for lipoprotein lipase deficiencyQ69608002
Mutation of tryptophan residues in lipoprotein lipase. Effects on stability, immunoreactivity, and catalytic propertiesQ71973560
Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domainQ74786238
Detailed characterization of the binding site of the lipoprotein lipase-specific monoclonal antibody 5D2Q77609917
Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitisQ87320688
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipaseQ89093967
Syndecan-1 Mediates Sorting of Soluble Lipoprotein Lipase with Sphingomyelin-Rich Membrane in the Golgi ApparatusQ90205234
Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibitionQ90784980
A lipoprotein lipase-GPI-anchored high-density lipoprotein-binding protein 1 fusion lowers triglycerides in mice: Implications for managing familial chylomicronemia syndromeQ90910334
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activityQ91241822
P433issue8
P304page(s)4337-4346
P577publication date2020-02-07
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleUnfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism
P478volume117