HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α

scientific article published on 07 February 2020

HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41388-020-1190-Y
P698PubMed publication ID32034309

P2093author name stringHui Wang
Xiaoguang Li
Jingquan Li
Qian Ba
Peizhan Chen
Xiaohua Duan
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HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.Q54588191
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.Q55043548
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MicroRNA-197 induces epithelial-mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinomaQ88391236
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancerQ92740315
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Sorafenib in advanced hepatocellular carcinomaQ27861075
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Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1Q33638575
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Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosisQ33864038
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.Q33928378
Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancerQ34340501
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.Q34616703
Transcatheter arterial chemoembolization: history for more than 30 years.Q34642418
HCC and angiogenesis: possible targets and future directionsQ35698574
Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.Q36380799
Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.Q37605156
Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapiesQ37746347
Hepatocellular Carcinoma: Review of Epidemiology, Screening, Imaging Diagnosis, Response Assessment, and Treatment.Q38483188
Heat shock modulates the subcellular localization, stability, and activity of HIPK2.Q38786741
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinomaQ38829170
MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinomaQ39480218
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradationQ39761954
Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.Q39898008
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.Q39910695
P433issue14
P304page(s)2863-2876
P577publication date2020-02-07
P1433published inOncogeneQ1568657
P1476titleHIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α
P478volume39

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