Artificial generation of centromeres and kinetochores to understand their structure and function

scientific article published on 06 February 2020

Artificial generation of centromeres and kinetochores to understand their structure and function is …
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P356DOI10.1016/J.YEXCR.2020.111898
P698PubMed publication ID32035949

P2093author name stringTatsuo Fukagawa
Tetsuya Hori
P2860cites workEvolutionary history of chromosome 11 featuring four distinct centromere repositioning events in CatarrhiniQ40134828
Telomere directed fragmentation of mammalian chromosomesQ40404539
The 10q25 neocentromere and its inactive progenitor have identical primary nucleotide sequence: further evidence for epigenetic modificationQ40414103
Genome sequence, comparative analysis, and population genetics of the domestic horseQ22065900
Comparative and demographic analysis of orang-utan genomesQ22122185
Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomesQ24300684
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.Q24321321
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeresQ24321377
CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochoreQ24324027
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progressionQ24338563
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatinQ24537593
Massive genomic rearrangement acquired in a single catastrophic event during cancer developmentQ24631164
Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeresQ24654940
A chromosomal memory triggered by Xist regulates histone methylation in X inactivationQ24802695
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylationQ25257502
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionQ26823191
Comprehensive mapping of long-range interactions reveals folding principles of the human genomeQ28131819
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeresQ28235274
Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromereQ28292622
Formation of de novo centromeres and construction of first-generation human artificial microchromosomesQ28306987
Molecular architecture of the kinetochore-microtubule interfaceQ29620741
HJURP interaction with the condensin II complex during G1 promotes CENP-A depositionQ30275512
Identification of the Post-translational Modifications Present in Centromeric ChromatinQ30277890
Histone variants and epigeneticsQ30301007
A two-step mechanism for epigenetic specification of centromere identity and functionQ30405362
The quantitative architecture of centromeric chromatinQ30411797
Putting CENP-A in its placeQ30412014
Posttranslational modification of CENP-A influences the conformation of centromeric chromatinQ30415280
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochoreQ30428662
Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errorsQ30433425
Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatidsQ40415592
Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.Q40460199
CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA.Q40686084
Sequence analysis of an 80 kb human neocentromereQ40825786
Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25.Q40829962
Centromeric protein B null mice are viable with no apparent abnormalitiesQ41008406
Construction of YAC-based mammalian artificial chromosomesQ41042021
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeresQ41887609
The Chromatin of Candida albicans Pericentromeres Bears Features of Both Euchromatin and Heterochromatin.Q42082600
The requirement for the Dam1 complex is dependent upon the number of kinetochore proteins and microtubulesQ42738105
Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeresQ43583151
Repeatless and repeat-based centromeres in potato: implications for centromere evolution.Q44446100
Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.Q46315066
Recurrent establishment of de novo centromeres in the pericentromeric region of maize chromosome 3.Q46317620
Decoding the centromeric nucleosome through CENP-N.Q47252230
Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.Q47263134
RNA interference demonstrates a novel role for H2A.Z in chromosome segregationQ47349040
Spindle asymmetry drives non-Mendelian chromosome segregation.Q47591701
Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis.Q47682737
Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian VertebratesQ47881808
Epigenetic modification of centromeric chromatin: hypomethylation of DNA sequences in the CENH3-associated chromatin in Arabidopsis thaliana and maizeQ48075232
Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genomeQ48265253
Non-B-form DNA is enriched at centromeres.Q49819293
Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore.Q49925401
Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Q50335532
Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas.Q51504406
A Kinesin-14 Motor Activates Neocentromeres to Promote Meiotic Drive in Maize.Q52328772
Heterochromatin integrity affects chromosome reorganization after centromere dysfunction.Q53458929
Dissecting the centromere of the human Y chromosome with cloned telomeric DNA.Q54692762
A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeastQ57887249
HJURP Involvement in De Novo CenH3CENP-A and CENP-C RecruitmentQ57898678
Sex and death: from cell fate specification to dynamic control of X-chromosome structure and gene expressionQ58083591
3D genomic architecture reveals that neocentromeres associate with heterochromatin regionsQ58610748
The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphismQ61800373
Centromere Repeats: Hidden Gems of the GenomeQ64084268
CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the CentromereQ64268218
A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNAQ73388111
Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomesQ83780163
Centromere repositioning causes inversion of meiosis and generates a reproductive barrierQ90616477
Sub-nucleosomal Genome Structure Reveals Distinct Nucleosome Folding MotifsQ91129373
Centromeric Satellite DNAs: Hidden Sequence Variation in the Human PopulationQ91891617
Human Artificial Chromosomes that Bypass Centromeric DNAQ92204339
Cis- and Trans-chromosomal Interactions Define Pericentric Boundaries in the Absence of Conventional HeterochromatinQ92381129
Multiple phosphorylations control recruitment of the KMN network onto kinetochoresQ93017200
H2A.Z contributes to the unique 3D structure of the centromereQ30478722
The cenpB gene is not essential in miceQ31915856
Intergenic locations of rice centromeric chromatinQ33391509
Neocentromeres form efficiently at multiple possible loci in Candida albicans.Q33415450
Human centromere repositioning "in progress"Q33695623
On the Anaphase Movement of ChromosomesQ33747011
A paucity of heterochromatin at functional human neocentromeresQ33751932
Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assemblyQ33844929
Transmission of a fully functional human neocentromere through three generationsQ33858852
A super-resolution map of the vertebrate kinetochoreQ33935029
Epigenetics in Saccharomyces cerevisiaeQ34037400
The case for epigenetic effects on centromere identity and function.Q34065789
Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequencesQ34085140
Neocentromeres: role in human disease, evolution, and centromere studyQ34146174
The centromere: chromatin foundation for the kinetochore machineryQ34160736
Cdk activity couples epigenetic centromere inheritance to cell cycle progression.Q34240608
Sequencing of a rice centromere uncovers active genesQ34289102
Histone chaperones, a supporting role in the limelightQ34305755
Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells.Q34321072
Chromosome engineering allows the efficient isolation of vertebrate neocentromeres.Q34333350
Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitroQ34451628
The architecture and evolution of cancer neochromosomesQ34454339
Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochoreQ34513328
Broad chromosomal domains of histone modification patterns in C. elegansQ34548272
Condensin-driven remodelling of X chromosome topology during dosage compensation.Q34670135
Neocentromeres: new insights into centromere structure, disease development, and karyotype evolutionQ34746589
H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phaseQ35079154
Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochoresQ35335808
Highly repeated DNA sequence limited to knob heterochromatin in maizeQ35406523
CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assemblyQ35514331
DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere FunctionQ35573549
Centromere repositioning in mammals.Q35614265
Centromere sliding on a mammalian chromosomeQ35657166
Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-CQ35871975
Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregationQ36061323
HJURP is involved in the expansion of centromeric chromatinQ36063750
Total centromere size and genome size are strongly correlated in ten grass speciesQ36080983
Propagation of centromeric chromatin requires exit from mitosis.Q36117994
Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weightsQ36289172
The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assemblyQ36525667
Inbreeding drives maize centromere evolutionQ36646304
Molecular architecture of the kinetochore-microtubule attachment site is conserved between point and regional centromeresQ36660656
Molecular underpinnings of centromere identity and maintenanceQ36734912
Genetic manipulation of centromere functionQ36843287
Epigenetic regulation of centromeric chromatin: old dogs, new tricks?Q36981211
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.Q37248320
Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeastQ37363489
Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeresQ37396227
Induction of centromeric activity in maize by suppressor of meiotic drive 1.Q37408565
Maize centromeres expand and adopt a uniform size in the genetic background of oat.Q37420321
Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakageQ37489797
Recurrent sites for new centromere seedingQ37496061
Constitutive centromere-associated network controls centromere drift in vertebrate cells.Q37576596
The ABCs of CENPsQ37900520
Establishment of the vertebrate kinetochoresQ38021698
The molecular basis for centromere identity and function.Q38645971
Conserved organization of centromeric chromatin in flies and humansQ38692366
Genetic complementation analysis showed distinct contributions of the N-terminal tail of H2A.Z to epigenetic regulationsQ38797473
Kinetochore assembly and function through the cell cycleQ38885455
Chromatin dynamics during the cell cycle at centromeresQ39110341
Critical histone post-translational modifications for centromere function and propagationQ39361927
Drosophila CENH3 is sufficient for centromere formation.Q39448107
Heterochromatin boundaries are hotspots for de novo kinetochore formationQ39521875
Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cellsQ39560198
Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachmentQ39859891
Heterochromatin, satellite DNA, and cell function. Structural DNA of eucaryotes may support and protect genes and aid in speciationQ40004460
CENP-B controls centromere formation depending on the chromatin contextQ40030884
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cellsQ40083781
P433issue2
P304page(s)111898
P577publication date2020-02-06
P1433published inExperimental Cell ResearchQ1524289
P1476titleArtificial generation of centromeres and kinetochores to understand their structure and function
P478volume389

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Q100295023Artificial chromosomescites workP2860

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