Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

scientific article published on 07 February 2020

Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/S41526-020-0097-9
P932PMC publication ID7005826
P698PubMed publication ID32047839

P2093author name stringAndrew G Lee
C Robert Gibson
Thomas H Mader
William Tarver
Tyson Brunstetter
Pejman Rabiei
Roy F Riascos
Laura A Galdamez
P2860cites workOptic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flightQ28245726
Orbital and Intracranial Effects of Microgravity: Findings at 3-T MR ImagingQ29041759
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Free radicals as triggers of brain edema formation after stroke.Q30990948
Effects of short-term mild hypercapnia during head-down tilt on intracranial pressure and ocular structures in healthy human subjects.Q33800250
Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflightsQ34112210
Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in spaceQ34249339
Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolismQ34251286
Ischemic optic neuropathyQ34898090
Venous system in acute brain injury: Mechanisms of pathophysiological change and functionQ36058993
Neuronal versus glial cell swelling in the ischaemic retinaQ36269637
Increased cerebral blood volume pulsatility during head-down tilt with elevated carbon dioxide: the SPACECOT Study.Q36329004
Pathogenesis of optic disc edema in raised intracranial pressureQ36422046
Ocular Outcomes Comparison Between 14- and 70-Day Head-Down-Tilt Bed RestQ36592572
Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressureQ36860290
Effects of short-term exposure to head-down tilt on cerebral hemodynamics: a prospective evaluation of a spaceflight analog using phase-contrast MRI.Q37009677
Cerebrospinal fluid outflow: an evolving perspectiveQ37269770
The effect of microgravity on ocular structures and visual function: a reviewQ38078107
Radiation therapy: posterior segment complicationsQ38132590
Compartmentalized cerebrospinal fluid.Q38168019
Lumbar puncture during spaceflight: operational considerations, constraints, concerns, and limitationsQ38283785
Space Flight-Associated Neuro-ocular SyndromeQ38400962
Neuro-Ophthalmology of Space FlightQ38439723
Spaceflight-Induced Intracranial HypertensionQ38534322
Mini-Review: Impaired Axonal Transport and GlaucomaQ38540617
Lower-body negative pressure decreases noninvasively measured intracranial pressure and internal jugular vein cross-sectional area during head-down tiltQ38790998
Elevated End-Tidal Pco2 During Long-Duration SpaceflightQ39357670
The translaminar pressure gradient in sustained zero gravity, idiopathic intracranial hypertension, and glaucomaQ39552265
Recent bed rest results and countermeasure development at NASA.Q40678799
Optic disc edema in raised intracranial pressure. I. Evolution and resolutionQ41278470
Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control studyQ43517619
Impaired cerebrovascular autoregulation and reduced CO₂ reactivity after long duration spaceflight.Q44672669
Doppler ultrasound of the central retinal artery in microgravityQ44698987
Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and CountermeasuresQ46434436
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virusQ47557035
Optical Coherence Tomography Analysis of the Optic Nerve Head and Surrounding Structures in Long-Duration International Space Station AstronautsQ47564682
Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronautsQ47966307
Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI.Q47991814
An international collaboration studying the physiological and anatomical cerebral effects of carbon dioxide during head-down tilt bed rest: the SPACECOT studyQ48195850
Quantitative MRI volumetry, diffusivity, cerebrovascular flow, and cranial hydrodynamics during head-down tilt and hypercapnia: the SPACECOT study.Q48226057
Human cerebral autoregulation before, during and after spaceflight.Q48329818
Effect of gravity and microgravity on intracranial pressure.Q48348877
Cerebrospinal fluid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional?Q48364902
The optic nerve: a new window into cerebrospinal fluid composition?Q48635006
Astronaut ophthalmic syndromeQ48643700
Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH).Q48658884
Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice.Q49294193
Why a One-Way Ticket to Mars May Result in One-Way Directional Glymphatic Flow to the Eye: ResponseQ49392340
Why a One-Way Ticket to Mars May Result in a One-Way Directional Glymphatic Flow to the Eye.Q49392349
Spaceflight and Neurosurgery: A Comprehensive Review of the Relevant LiteratureQ50072570
Author Response: Optic Nerve Sheath Distention as a Protective Mechanism Against the Visual Impairment and Intracranial Pressure Syndrome in AstronautsQ50152453
Alterations in adaptive immunity persist during long-duration spaceflight.Q50971022
Persistent Asymmetric Optic Disc Swelling After Long-Duration Space Flight: Implications for Pathogenesis.Q51022744
Volumetric Ophthalmic Ultrasound for Inflight Monitoring of Visual Impairment and Intracranial Pressure.Q51736994
Brain structural plasticity with spaceflight.Q51811291
Structural Brain Changes following Long-Term 6° Head-Down Tilt Bed Rest as an Analog for Spaceflight.Q52151917
Non-Invasive Intracranial Pressure Estimation During Combined Exposure to CO₂ and Head-Down Tilt.Q52382166
Space flight-associated neuro-ocular syndrome (SANS).Q52661826
Ophthalmic Changes Associated with Long-Term Exposure to Microgravity.Q52956674
Why Space Flight-Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension-Reply.Q53071202
Choroidal Folds in Astronauts.Q53087234
Relationship between carbon dioxide levels and reported headaches on the international space station.Q53090315
Unilateral loss of spontaneous venous pulsations in an astronaut.Q53093480
Lower body negative pressure reduces optic nerve sheath diameter during head-down tilt.Q53106369
Why Space Flight-Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension.Q53396420
Lower body negative pressure to safely reduce intracranial pressureQ57028895
Brain Tissue-Volume Changes in CosmonautsQ57788299
Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic AnalysisQ58697167
Intracranial and Intraocular Pressure During Various Degrees of Head-Down TiltQ60548654
Intraocular pressure, retinal vascular, and visual acuity changes during 48 hours of 10 degrees head-down tiltQ68605199
Intraocular pressure and retinal vascular changes during transient exposure to microgravityQ70583494
Cerebral blood velocity and other cardiovascular responses to 2 days of head-down tiltQ70589025
Physical examination during space flightQ73273659
Cardiac, arterial and venous adaptation to weightlessness during 6-month MIR spaceflights with and without thigh cuffs (bracelets)Q73633874
Circulation and axonal transport in the optic nerveQ80981254
Asymmetric Papilledema in Idiopathic Intracranial Hypertension: CommentQ87309609
Spaceflight-Induced Visual Impairment and Globe Deformations in Astronauts Are Linked to Orbital Cerebrospinal Fluid Volume IncreaseQ87916382
Internal Jugular Vein Volume During Head-Down Tilt and Carbon Dioxide Exposure in the SPACECOT StudyQ88122835
Microgravity-induced ocular changes are related to body weightQ88693107
Association of Space Flight With Problems of the Brain and EyesQ89440472
Ultrasound Guided Lumbar Puncture and Remote Guidance for Potential In-Flight Evaluation of VIIP/SANSQ90717664
Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid RedistributionQ91182370
Spaceflight-related ocular changes: the potential role of genetics, and the potential of B vitamins as a countermeasureQ91249471
Longitudinal Analysis of Quantitative Brain MRI in Astronauts Following Microgravity ExposureQ91734968
Dilated Prelaminar Paravascular Spaces as a Possible Mechanism for Optic Disc Edema in AstronautsQ93378856
P4510describes a project that usesVision Impairment and Intracranial PressureQ114813246
P921main subjectmicrogravityQ48655
P304page(s)7
P577publication date2020-02-07
P1433published innpj MicrogravityQ50817217
P1476titleSpaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update
P478volume6

Reverse relations

Q100467271Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flightcites workP2860

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