Redox regulation in tumor cell epithelial-mesenchymal transition: molecular basis and therapeutic strategy

scientific article published on 18 August 2017

Redox regulation in tumor cell epithelial-mesenchymal transition: molecular basis and therapeutic strategy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SIGTRANS.2017.36
P932PMC publication ID5661624
P698PubMed publication ID29263924

P2093author name stringYan Chen
Edouard C Nice
Kui Wang
Canhua Huang
Jingwen Jiang
Haining Chen
P2860cites workIncreased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubesQ23909385
Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2Q24296406
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growthQ24296787
Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumorsQ24296819
Redox switch for actin.Q52763666
Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.Q53317472
Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicinQ73253458
Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesionQ84279654
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cellsQ84623806
EMT: Matter of Life or Death?Q87377972
Integrin-regulated FAK-Src signaling in normal and cancer cellsQ24300271
FAK promotes recruitment of talin to nascent adhesions to control cell motilityQ24303404
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationQ24307387
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasionQ24321517
Redox modification of nuclear actin by MICAL-2 regulates SRF signalingQ24321526
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motilityQ24338202
Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347Q24647995
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
The basics of epithelial-mesenchymal transitionQ24652992
Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in CancerQ26741846
Cancer drug resistance: redox resetting renders a wayQ26750753
Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosisQ26779846
Therapeutic strategies targeting cancer stem cellsQ26781398
Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunitiesQ26828930
E-cadherin-integrin crosstalk in cancer invasion and metastasisQ26851155
Epithelial-mesenchymal plasticity in carcinoma metastasisQ26859804
Regulation of mTORC1 by PI3K signalingQ26995791
Beyond oxidative stress: an immunologist's guide to reactive oxygen speciesQ27011356
Nanomedicine therapeutic approaches to overcome cancer drug resistanceQ27011692
Molecular mechanisms of epithelial-mesenchymal transitionQ27013743
Cancer invasion and the microenvironment: plasticity and reciprocityQ27024382
FAK in cancer: mechanistic findings and clinical applicationsQ27026533
Reactive oxygen species regulate protrusion efficiency by controlling actin dynamicsQ27332266
Molecular and structural basis for redox regulation of beta-actinQ27644856
Distinctive properties of metastasis-initiating cellsQ28069801
Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer ProgressionQ28081012
Anoikis mechanismsQ28215553
Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cellsQ28297542
Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatmentQ28546067
N-acetylcysteine: multiple clinical applicationsQ37557560
Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesisQ37565029
Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapiesQ37610799
Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and diseaseQ37630599
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapyQ37662142
Targeting anoikis resistance in prostate cancer metastasisQ37691830
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factorsQ37693081
Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cellsQ37707761
EMT and oxidative stress: a bidirectional interplay affecting tumor malignancyQ37935008
Redox control of cell proliferationQ38040918
TGF-β signaling and epithelial-mesenchymal transition in cancer progressionQ38063807
Redox regulation in stem-like cancer cells by CD44 variant isoforms.Q38075424
Redox circuitries driving Src regulationQ38125488
Tumor and its microenvironment: a synergistic interplayQ38135172
Regulation of protein tyrosine phosphatase oxidation in cell adhesion and migrationQ38151172
Epithelial plasticity: a common theme in embryonic and cancer cells.Q38160727
Link between PI3K/AKT/PTEN Pathway and NOX Proteinin DiseasesQ38217855
Cellular and metabolic functions for autophagy in cancer cellsQ38256306
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.Q38311815
Intermediate filaments in cell migration and invasion: the unusual suspects.Q38347290
Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell deathQ38429249
Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitorQ38453542
Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial-mesenchymal transition in cancerQ38508400
High-throughput screening of cellular redox sensors using modern redox proteomics approachesQ38549071
Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic responseQ38603618
The front and rear of collective cell migration.Q38685677
TNF and ROS Crosstalk in InflammationQ38704621
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeuticsQ38722720
An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.Q38741291
Endosomes: Emerging Platforms for Integrin-Mediated FAK SignallingQ38761440
Coordinate Activation of Redox-Dependent ASK1/TGF-β Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in MiceQ38831339
Tight junctions: from simple barriers to multifunctional molecular gatesQ38879992
Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-κB axisQ38892839
Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expressionQ38912201
Hexavalent chromium induces expression of mesenchymal and stem cell markers in renal epithelial cellsQ28595762
Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cellsQ28686883
Reversible inactivation of the tumor suppressor PTEN by H2O2Q29615204
Modulation of oxidative stress as an anticancer strategyQ29615707
Collective cell migration in morphogenesis, regeneration and cancerQ29616634
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Q29616804
Cell adhesion: integrating cytoskeletal dynamics and cellular tensionQ29618066
Matrix metalloproteinases: regulators of the tumor microenvironmentQ29619858
An overview of epithelio-mesenchymal transformationQ30014826
Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transitionQ30164178
Evidence for thiol/disulfide exchange reactions between tubulin and glyceraldehyde-3-phosphate dehydrogenase.Q30370225
CD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: A target for cholangiocarcinoma treatment.Q30378139
CetZ tubulin-like proteins control archaeal cell shapeQ30630847
F-actin dismantling through a redox-driven synergy between Mical and cofilinQ30791894
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breastQ33502878
The therapeutic promise of the cancer stem cell conceptQ33559711
Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidationQ33630136
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativityQ33724429
ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of SnailQ33757116
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS releaseQ33913079
Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growthQ33925322
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.Q34045380
Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent mannerQ34135937
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
The epigenetics of epithelial-mesenchymal plasticity in cancerQ34310378
Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cellsQ34334633
A mitochondrial thioredoxin-sensitive mechanism regulates TGF-β-mediated gene expression associated with epithelial-mesenchymal transitionQ34392183
Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationshipsQ35117865
Redox modulation of FAK controls melanoma survival--role of NOX4.Q35183930
Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma modelQ35207685
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancerQ35230326
Crosstalk of reactive oxygen species and NF-κB signalingQ35347850
Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathwayQ35632587
HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal CancerQ35658289
Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complexQ35744526
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling.Q35800372
Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axisQ38919625
Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cellsQ39070884
Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cellsQ39079470
Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanismQ39092295
Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasionQ39160417
Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD.Q39167027
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxiaQ39224802
FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migrationQ39272171
BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondriaQ39352908
Epithelial mesenchymal transition correlates with CD24+CD44+ and CD133+ cells in pancreatic cancerQ39398830
Radiation induces epithelial-mesenchymal transition in colorectal cancer cellsQ39463233
Increased expression of urokinase-type plasminogen activator mRNA determines adverse prognosis in ErbB2-positive primary breast cancerQ39768210
Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.Q40015294
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.Q40016539
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.Q40121429
TGFβ1 rapidly activates Src through a non-canonical redox mechanismQ40438170
TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells.Q40462552
Antioxidant effect of zinc in humansQ40510598
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizerQ40558625
Asbestos-derived reactive oxygen species activate TGF-beta1.Q40560323
Nickel-induced histone hypoacetylation: the role of reactive oxygen speciesQ40644037
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established diseaseQ40666383
Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulationQ40795994
Redox changes of cultured endothelial cells and actin dynamicsQ40893463
Translational Activation of HIF1α by YB-1 Promotes Sarcoma MetastasisQ40948678
Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transductionQ41028632
Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosisQ41312477
Integrins and anoikisQ41612562
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses CysteineQ41851711
Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism.Q41865139
H2O2-treated actin: assembly and polymer interactions with cross-linking proteinsQ42171687
Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.Q42707271
Redox regulation of beta-actin during integrin-mediated cell adhesion.Q42800696
Paraquat-induced cytoskeletal injury in cultured cellsQ42806571
Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species.Q42831305
Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase-2 (MMP-2) via NAD(P)H Oxidase–Derived Reactive Oxygen SpeciesQ44443254
Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.Q46021896
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α.Q46464793
Advanced Oxidation Protein Products Induce Epithelial-Mesenchymal Transition of Intestinal Epithelial Cells via a PKC δ-Mediated, Redox-Dependent Signaling PathwayQ46496553
Microscopic analysis of the chromium content in the chromium-induced malignant and premalignant bronchial lesions of the rat.Q46728411
Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivationQ46778434
Lung cancer among workers in chromium chemical productionQ47667127
Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteinsQ48418506
Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition.Q35852067
Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinomaQ35865016
Redox regulation of cell migration and adhesionQ35889032
Glucose oxidation modulates anoikis and tumor metastasis.Q35943920
Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.Q36044398
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylationQ36127152
Copper-zinc superoxide dismutase and amyotrophic lateral sclerosisQ36161189
Carcinogenic effect of nickel compoundsQ36311595
Phosphorylation and isoform use in p120-catenin during development and tumorigenesisQ36315812
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancerQ36544947
Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate CancerQ36586089
ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cellsQ36625600
Loss of α-Tubulin Acetylation Is Associated with TGF-β-induced Epithelial-Mesenchymal TransitionQ36650414
Oxidants, antioxidants and the current incurability of metastatic cancersQ36702422
Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinomaQ36817344
Molecular basis of NF-κB signalingQ36918115
Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunitiesQ36960756
NF-kappaB and epithelial to mesenchymal transition of cancerQ37078242
Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast CarcinomaQ37190619
Reactive oxygen species regulate a slingshot-cofilin activation pathwayQ37207711
Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cellsQ37233640
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarityQ37342290
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasionQ37374521
EMT, the cytoskeleton, and cancer cell invasionQ37377630
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbetaQ37406535
Chromium-induced kidney diseaseQ37439842
Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinomaQ37520250
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)17036
P577publication date2017-08-18
P1476titleRedox regulation in tumor cell epithelial-mesenchymal transition: molecular basis and therapeutic strategy
P478volume2

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cites work (P2860)
Q89551953A Network-Based Approach for Identification of Subtype-Specific Master Regulators in Pancreatic Ductal Adenocarcinoma
Q91725356A Quantitative Method to Measure Low Levels of ROS in Nonphagocytic Cells by Using a Chemiluminescent Imaging System
Q102388835CDX2 inhibits epithelial-mesenchymal transition in colorectal cancer by modulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression
Q53689438DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells.
Q90613463Deferoxamine Enhanced Mitochondrial Iron Accumulation and Promoted Cell Migration in Triple-Negative MDA-MB-231 Breast Cancer Cells Via a ROS-Dependent Mechanism
Q64055917EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology
Q58721561Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
Q92543211Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve
Q92005533Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA
Q99591516Green Synthesis of Lutein-Based Carbon Dots Applied for Free-Radical Scavenging within Cells
Q92309626HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist
Q62771966Integrative network biology analysis identifies miR-508-3p as the determinant for the mesenchymal identity and a strong prognostic biomarker of ovarian cancer
Q91826299Metabolic rewiring and redox alterations in malignant pleural mesothelioma
Q92542993Mitochondrial Involvement in Migration, Invasion and Metastasis
Q91761860Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments
Q64104859Modulation of Antioxidant Potential with Coenzyme Q10 Suppressed Invasion of Temozolomide-Resistant Rat Glioma and
Q64386940PARP3 comes to light as a prime target in cancer therapy
Q92070166PM2.5, Fine Particulate Matter: A Novel Player in the Epithelial-Mesenchymal Transition?
Q64257929Protective Effect of Extract against Irradiation-Induced Acute Hepatitis
Q99731951Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis
Q59810238Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways
Q91642619Treatment of Metastatic or High-Risk Solid Cancer Patients by Targeting the Immune System and/or Tumor Burden: Six Cases Reports
Q91792577ZEB1 promotes invasion and metastasis of endometrial cancer by interacting with HDGF and inducing its transcription
Q92701964p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines

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