Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis

scientific article published on 17 August 2017

Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis is …
instance of (P31):
case reportQ2782326
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOODADVANCES.2017007526
P932PMC publication ID5728466
P698PubMed publication ID29296794

P50authorJulie-An TalanoQ73392651
Larisa BroglieQ89777235
P2093author name stringSridhar Rao
David Margolis
Rachel Phelan
Lauren Pommert
Monica Thakar
P2860cites workSuccessful use of the anti-CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosisQ42576897
Alpha-CD25 antibody treatment in a child with hemophagocytic lymphohistiocytosisQ43867826
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.Q45930884
Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.Q53916622
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis.Q54533845
Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroidsQ82950882
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritisQ84751886
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosisQ33399977
Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor ruxolitinibQ33402522
Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosisQ33429617
Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controlsQ33843390
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.Q34433867
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.Q34561113
Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocolQ35525318
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter surveyQ36862931
Biology and significance of the JAK/STAT signalling pathwaysQ37146441
Salvage therapy for refractory hemophagocytic lymphohistiocytosis: A review of the published experienceQ38992336
Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosisQ40360876
Success with infliximab in treating refractory hemophagocytic lymphohistiocytosisQ40490433
Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.Q42260141
P433issue19
P921main subjecthemophagocytic lymphohistiocytosisQ1642170
ruxolitinibQ7383611
P304page(s)1533-1536
P577publication date2017-08-17
P1476titleRuxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis
P478volume1

Reverse relations

cites work (P2860)
Q90857636A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Q95840998Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity
Q91973589Diagnosis and Management of Secondary HLH/MAS Following HSCT and CAR-T Cell Therapy in Adults; A Review of the Literature and a Survey of Practice Within EBMT Centres on Behalf of the Autoimmune Diseases Working Party (ADWP) and Transplant Complicat
Q91763430Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis
Q90249953Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis
Q99561362Primary immune regulatory disorders: a growing universe of immune dysregulation
Q90746855Recent advances in primary immunodeficiency: from molecular diagnosis to treatment
Q91844259Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib
Q90181685Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial
Q92525829Salvage therapy with dose-escalating ruxolitinib as a bridge to allogeneic stem cell transplantation for refractory hemophagocytic lymphohistiocytosis
Q90745265The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature
Q95637970The immunology of COVID-19: is immune modulation an option for treatment?
Q89540069Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid
Q95264258Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

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