A novel BCL-2 inhibitor APG-2575 exerts synthetic lethality with BTK or MDM2-P53 inhibitor in Diffuse Large B-Cell Lymphoma

scientific article published on 24 February 2020

A novel BCL-2 inhibitor APG-2575 exerts synthetic lethality with BTK or MDM2-P53 inhibitor in Diffuse Large B-Cell Lymphoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3727/096504020X15825405463920
P932PMC publication ID7851508
P698PubMed publication ID32093809

P2093author name stringLin Yang
Jing Wang
Jian Sun
Suna Zhou
Zhenyi Liu
Haibo Chen
Hanjie Yi
Qiuyun Luo
Xianglei Yan
Guangfeng Wang
Luping Yuan
DaJun Yang
MiaoZhen Qiu
Wentao Pan
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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitorQ29616727
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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.Q35250940
Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaQ35958056
Immunoexpression of Ki-67, MCM2, and MCM3 in Ameloblastoma and Ameloblastic Carcinoma and Their Correlations with Clinical and Histopathological PatternsQ36448578
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BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphomaQ40357519
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.Q40716705
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocationQ44926251
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic EfficacyQ47302512
A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma.Q52714998
Targeting the B cell receptor pathway in non-Hodgkin lymphoma.Q54977449
Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicineQ57496075
Diffuse large B-cell lymphomaQ60019700
Non-Hodgkin lymphomaQ84629067
Selective targeting of antiapoptotic BCL-2 proteins in cancerQ88918023
Venetoclax active and safe in non-Hodgkin lymphomaQ89895543
P4510describes a project that usesImageJQ1659584
P921main subjectdiffuse large B-cell lymphomaQ2626074
P577publication date2020-02-24
P1433published inOncology ResearchQ15750114
P1476titleA novel BCL-2 inhibitor APG-2575 exerts synthetic lethality with BTK or MDM2-P53 inhibitor in Diffuse Large B-Cell Lymphoma

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Q97531386MDM2 inhibition: an important step forward in cancer therapycites workP2860

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