Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations

scientific article published on 01 February 2020

Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.4093/DMJ.2019.0208
P932PMC publication ID7043991
P698PubMed publication ID32097996

P50authorWayne Huey-Herng SheuQ89111214
Kun Ho YoonQ89368209
P2093author name stringChaicharn Deerochanawong
Andrea Luk
Ketut Suastika
Ambrish Mithal
Siew Pheng Chan
Chin Meng Khoo
Bien J Matawaran
Juliana Chan
Ji Linong
Huu Man Nguyen
P2860cites workEctopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventionsQ21285128
Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes MellitusQ22241140
Metformin monotherapy for type 2 diabetes mellitusQ24246552
The role of fatty acids in insulin resistanceQ26785440
Metabolic syndrome and kidney disease: a systematic review and meta-analysisQ26863240
GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patientsQ28276621
Effect of anti-obesity drug on cardiovascular risk factors: a systematic review and meta-analysis of randomized controlled trialsQ28480564
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategiesQ29614505
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013Q29616834
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialQ29619886
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
Health Effects of Overweight and Obesity in 195 Countries over 25 YearsQ30402965
Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trialQ30539603
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetesQ30548796
Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trialQ30651606
A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: an overview of individual participant data from 32 prospective cohorts from the Asia-Pacific RegionQ30828094
Efficacy and safety of empagliflozin in patients with type 2 diabetes from Asian countries: pooled data from four phase III trialsQ31105792
Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparQ33612741
Efficacy and safety of canagliflozin as add-on therapy to teneligliptin in Japanese patients with type 2 diabetes mellitus: Results of a 24-week, randomized, double-blind, placebo-controlled trialQ33835558
A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trialsQ33874163
A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD studyQ33888204
Long-term safety and efficacy of tofogliflozin add-on to insulin in patients with type 2 diabetes: results from a 52-week, multicenter, randomized, double-blind, open-label extension, Phase 4 study in Japan (J-STEP/INS).Q48279607
Comparison of Ipragliflozin and Pioglitazone Effects on Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Randomized, 24-Week, Open-Label, Active-Controlled Trial.Q48333756
Long-term efficacy and safety of canagliflozin in combination with insulin in Japanese patients with type 2 diabetes mellitusQ48353746
Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label periodQ49963630
Dapagliflozin Reduces Fat Mass without Affecting Muscle Mass in Type 2 DiabetesQ49963693
Dapagliflozin as add-on therapy in Asian patients with type 2 diabetes inadequately controlled on insulin with or without oral antihyperglycemic drugs: A randomized controlled trial.Q50035752
Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week, open-label, phase IV study.Q51246665
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.Q51304272
Efficacy and safety of empagliflozin monotherapy for 52 weeks in Japanese patients with type 2 diabetes: a randomized, double-blind, parallel-group study.Q51305217
Efficacy and safety of canagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled with diet and exercise: a 24-week, randomized, double-blind, placebo-controlled, Phase III study.Q51319263
Empagliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: a randomized, 12-week, double-blind, placebo-controlled, phase II trial.Q51320301
Efficacy and safety of dapagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise.Q51321207
Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study.Q51329266
Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial.Q51348266
Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women.Q51473217
Appropriate waist circumference cutoff points for central obesity in Korean adults.Q51497292
Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice.Q51561479
CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis.Q51707689
Dapagliflozin improves treatment satisfaction in overweight patients with type 2 diabetes mellitus: a patient reported outcome study (PRO study).Q51744128
Ipragliflozin effectively reduced visceral fat in Japanese patients with type 2 diabetes under adequate diet therapy.Q53128290
Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment.Q55386487
Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)Q56979722
Weight loss associated with sodium-glucose cotransporter-2 inhibition: a review of evidence and underlying mechanismsQ57150764
Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participantsQ57265839
Measures of Abdominal Adiposity and the Risk of StrokeQ57605696
C-Reactive Protein and Cerebral Small-Vessel DiseaseQ57781994
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?Q58036996
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in AdultsQ61985181
Adverse Effect Profile and Effectiveness of Sodium Glucose Co-transporter 2 Inhibitors (SGLT2i) - A Prospective Real-world Setting StudyQ64294876
Central obesity and risk of cardiovascular disease in the Asia Pacific RegionQ79892212
Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitusQ86932366
Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)Q89080794
Comparison of pancreatic volume and fat amount linked with glucose homeostasis between healthy Caucasians and KoreansQ89208553
Use of sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors: An Asian perspective and expert recommendationsQ91544396
Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current StatusQ92141984
2019 Clinical Practice Guidelines for Type 2 Diabetes Mellitus in KoreaQ92807729
Dapagliflozin and Cardiovascular Outcomes in Type 2 DiabetesQ92980564
Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomized contQ93146539
Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysisQ34031108
Randomized, placebo-controlled, double-blind glycemic control trial of novel sodium-dependent glucose cotransporter 2 inhibitor ipragliflozin in Japanese patients with type 2 diabetes mellitusQ34407893
Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of DiabetesQ34457919
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesQ34673134
Dapagliflozin as monotherapy or combination therapy in Japanese patients with type 2 diabetes: an open-label studyQ34726376
Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysisQ34985373
SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trialsQ35181821
Efficacy and safety of canagliflozin alone or as add-on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: A 52-week open-label study.Q35192198
Long-term follow-up after bariatric surgery: a systematic review.Q35237039
One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD studyQ35819788
Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass indexQ35825660
Efficacy and safety of luseogliflozin added to various oral antidiabetic drugs in Japanese patients with type 2 diabetes mellitusQ35879325
Lifestyle change and mobility in obese adults with type 2 diabetesQ35919090
Energy Balance After Sodium-Glucose Cotransporter 2 InhibitionQ35973288
Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trialQ36126490
Obesity and diabetic kidney diseaseQ36515043
International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countriesQ36777590
Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesisQ36825515
Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.Q36843902
Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus from IndiaQ36867463
Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors.Q36964821
Efficacy and safety of canagliflozin in combination with insulin: a double-blind, randomized, placebo-controlled study in Japanese patients with type 2 diabetes mellitusQ37018165
Efficacy and safety of dapagliflozin in addition to insulin therapy in Japanese patients with type 2 diabetes: Results of the interim analysis of 16-week double-blind treatment periodQ37060860
Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetesQ37250961
Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertensionQ37262554
Changes in Levels of Biomarkers Associated with Adipocyte Function and Insulin and Glucagon Kinetics During Treatment with Dapagliflozin Among Obese Type 2 Diabetes Mellitus PatientsQ37302700
Standards of care for type 2 diabetes in China.Q37412792
Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus living in hot climatesQ37456313
Impact of the 8-week Administration of Tofogliflozin for Glycemic Control and Body Composition in Japanese Patients with Type 2 Diabetes MellitusQ37521103
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patientsQ37524302
Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, 12-week studyQ37532069
Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot studyQ37679243
Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatmentQ37873715
Sleep apnoea and metabolic dysfunctionQ38133503
Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetesQ38204541
Effect of orlistat on glycaemic control in overweight and obese patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trialsQ38582254
Canagliflozin and Cardiovascular and Renal Events in Type 2 DiabetesQ38729780
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY.Q38843101
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.Q38912082
Diuretic Action of Sodium-Glucose Cotransporter 2 Inhibitors and Its Importance in the Management of Heart FailureQ38947399
Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis.Q39393777
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP LevelsQ39629318
Comprehensive risk assessments of diabetic patients from seven Asian countries: The Joint Asia Diabetes Evaluation (JADE) programQ39983936
Efficacy and safety of tofogliflozin in Japanese patients with type 2 diabetes mellitus with inadequate glycaemic control on insulin therapy (J-STEP/INS): Results of a 16-week randomized, double-blind, placebo-controlled multicentre trialQ40266818
Safety and Effectiveness of Tofogliflozin in Elderly Japanese Patients with Type 2 Diabetes Mellitus: a Post-Marketing Study (J-STEP/EL Study).Q40363925
Efficacy and safety of dapagliflozin over 1 year as add-on to insulin therapy in Japanese patients with type 2 diabetes: the DAISY (Dapagliflozin Added to patients under InSulin therapY) trialQ40405896
Hypertension, Obesity, Diabetes, and Heart Failure-Free Survival: The Cardiovascular Disease Lifetime Risk Pooling ProjectQ40446172
Efficacy and safety of ipragliflozin as add-on therapy to insulin in Japanese patients with type 2 diabetes mellitus (IOLITE): a multi-centre, randomized, placebo-controlled, double-blind studyQ40606871
Efficacy and safety of dapagliflozin in Asian patients with type 2 diabetes after metformin failure: A randomized controlled trialQ40901927
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.Q41084455
Fifty-two-week long-term clinical study of luseogliflozin as monotherapy in Japanese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise.Q41234175
Ipragliflozin Reduces Epicardial Fat Accumulation in Non-Obese Type 2 Diabetic Patients with Visceral Obesity: A Pilot StudyQ41259429
Comparison of Combined Tofogliflozin and Glargine, Tofogliflozin Added to Insulin, and Insulin Dose-Increase Therapy in Uncontrolled Type 2 DiabetesQ41277849
Canagliflozin in Asian patients with type 2 diabetes on metformin alone or metformin in combination with sulphonylureaQ41759692
Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 DiabetesQ42718201
Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trialQ42732735
Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetesQ43100917
Ipragliflozin in combination with metformin for the treatment of Japanese patients with type 2 diabetes: ILLUMINATE, a randomized, double-blind, placebo-controlled studyQ43165555
Relationship of abdominal obesity with cardiovascular disease, diabetes and hyperlipidaemia in SpainQ43260778
Commentary: Why are South Asians susceptible to central obesity?--the El Niño hypothesisQ44128167
Obesity and kidney disease in type 1 and 2 diabetes: an analysis of the National Diabetes AuditQ44154005
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular eventsQ44216708
A central body fat distribution is related to renal function impairment, even in lean subjectsQ44383378
Repaglinide versus nateglinide monotherapy: a randomized, multicenter studyQ44909493
Body mass index, diabetes, and C-reactive protein among U.S. adultsQ46780760
Long-term safety and efficacy of canagliflozin as add-on therapy to teneligliptin in Japanese patients with type 2 diabetes.Q47148933
The Association Between the Dosage of SGLT2 Inhibitor and Weight Reduction in Type 2 Diabetes Patients: A Meta-Analysis.Q47175811
Changes in weight loss-related quality of life among type 2 diabetes mellitus patients treated with dapagliflozinQ47187857
Impact of Canagliflozin Treatment on Health-Related Quality of Life among People with Type 2 Diabetes Mellitus: A Pooled Analysis of Patient-Reported Outcomes from Randomized Controlled TrialsQ47192734
A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.Q47374718
Safety and efficacy of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice: interim results of the STELLA-LONG TERM post-marketing surveillance studyQ47398293
CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2018 EXECUTIVE SUMMARY.Q47556600
Ipragliflozin, a sodium glucose co-transporter 2 inhibitor, reduces intrahepatic lipid content and abdominal visceral fat volume in patients with type 2 diabetesQ47996942
Sodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: A 52-week, open-label,Q48147721
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue1
P921main subjecttype 2 diabetesQ3025883
P304page(s)11-32
P577publication date2020-02-01
P1433published inDiabetes & metabolism journalQ26842420
P1476titleUse of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations
P478volume44

Reverse relations

cites work (P2860)
Q90453455Lowering the Risk of Gout: Another Benefits from Use of SGLT2 Inhibitors
Q98612863SGLT2 Inhibitors as Add-On Therapy to Metformin for People with Type 2 Diabetes: A Review of Placebo-Controlled Trials in Asian versus Non-Asian Patients

Search more.