Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases

scientific article published on 01 April 2020

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/JNEN/NLAA007
P932PMC publication ID7092360
P698PubMed publication ID32106300

P2093author name stringDennis W Dickson
Benoit I Giasson
Stefan Prokop
Anthony T Yachnis
Zachary A Sorrentino
Cara J Riffe
Jorge A Trejo-Lopez
P2860cites workCullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signalingQ24308725
Second consensus statement on the diagnosis of multiple system atrophyQ24650965
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathyQ28085165
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse modelQ28115206
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathiesQ28205799
Protein aggregation and neurodegenerative diseaseQ28273600
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Autophagy gone awry in neurodegenerative diseasesQ29614849
Evaluation of alpha-synuclein immunohistochemical methods used by invited expertsQ30488694
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Q30585365
Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivityQ33735667
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB ConsortiumQ33869820
Mallory bodies revisitedQ33899979
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synucleinQ34091623
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistryQ34556945
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseQ34635272
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesisQ34768397
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagyQ35580643
Diffuse plaques do not accentuate synapse loss in Alzheimer's diseaseQ35812116
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.Q35990138
Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease.Q36626380
Signal integration and diversification through the p62 scaffold proteinQ36686435
Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders.Q36790701
Thinking laterally about neurodegenerative proteinopathiesQ36793466
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in miceQ36907399
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategyQ36932383
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse modelQ37063351
Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.Q37485777
p62/SQSTM1/A170: physiology and pathologyQ38030264
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.Q38084406
The neuropathology associated with repeat expansions in the C9ORF72 geneQ38172839
New Perspectives on the Neuropathology in Huntington's Disease in the Human Brain and its Relation to Symptom VariationQ38234070
Interactions of pathological proteins in neurodegenerative diseasesQ39236779
Relationship between plaques, tangles, and dystrophic processes in Alzheimer's diseaseQ40416719
Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Q41196178
Autophagy-deficient mice develop multiple liver tumorsQ42099409
p62 Is a common component of cytoplasmic inclusions in protein aggregation diseasesQ42184099
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.Q42491649
Neuropathological classification of Huntington's diseaseQ45297167
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.Q45967668
Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.Q47300849
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62Q48319617
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.Q48550878
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synucleinQ48581887
Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.Q53352974
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.Q54613756
Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.Q55392669
Physiological carboxy-truncation of α-synuclein potentiates the prion-like formation of pathological inclusionsQ57458019
p62 mutations, ubiquitin recognition and Paget's disease of boneQ58096580
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALSQ58477808
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.Q61718173
The ubiquitin-binding protein p62 identifies argyrophilic grain pathology with greater sensitivity than conventional silver stainsQ79405792
Use of p62/SQSTM1 antibodies for neuropathological diagnosisQ81500829
Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathologyQ91005182
Astrocytic degeneration in chronic traumatic encephalopathyQ91337171
Repeat-associated non-AUG (RAN) translation: insights from pathologyQ92659224
P433issue4
P304page(s)407-418
P577publication date2020-04-01
P1433published inJournal of Neuropathology & Experimental NeurologyQ15716771
P1476titleGeneration and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases
P478volume79

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