Activation of a novel estrogen receptor GPR30 enhances cholesterol cholelithogenesis in female mice

scientific article published on 29 February 2020

Activation of a novel estrogen receptor GPR30 enhances cholesterol cholelithogenesis in female mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.31212
P932PMC publication ID8157628
P698PubMed publication ID32112420

P50authorChristopher K ArnattQ92410167
Min LiuQ110853237
P2093author name stringDavid Q-H Wang
Piero Portincasa
Helen H Wang
Ornella de Bari
P2860cites workDifferent hepatobiliary effects of oral and transdermal estradiol in postmenopausal womenQ67982204
Effect of female sex hormones on lithogenicity of bileQ70315498
Oral contraceptives raise the cholesterol saturation of bile by increasing biliary cholesterol secretionQ71130150
Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbitsQ73933606
A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell GrowthQ91789012
A transmembrane intracellular estrogen receptor mediates rapid cell signalingQ24294726
Bile acids: regulation of synthesisQ24658139
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Discovery of three novel G-protein-coupled receptor genesQ28115718
Effects of Oral Contraceptives on the Gallbladder Bile of Normal WomenQ28215666
Bile acids: trying to understand their chemistry and biology with the hope of helping patientsQ28238498
RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunitsQ28287870
Genome-wide analysis of estrogen receptor binding sitesQ29614765
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGFQ29615227
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacologyQ34132652
Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolismQ34177319
Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancerQ34446120
Production and actions of estrogensQ34513002
Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice.Q35994356
The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female miceQ36429659
Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genesQ36646394
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.Q37083658
Biliary lipids and cholesterol gallstone diseaseQ37328736
New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation.Q37374183
Lith genes and genetic analysis of cholesterol gallstone formationQ37755733
The diversity of sex steroid action: regulation of metabolism by estrogen signalingQ37867854
Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligandQ44193757
Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstonesQ44965240
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM.Q46440991
GPR30: a novel therapeutic target in estrogen-related diseaseQ46762264
Overexpression of estrogen receptor alpha increases hepatic cholesterogenesis, leading to biliary hypersecretion in miceQ46870354
Virtual and biomolecular screening converge on a selective agonist for GPR30.Q46978096
Hepatic cholesterol metabolism in estrogen-treated menQ50193329
Mouse models of gallstone disease.Q52406843
G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis.Q54403883
GPR30 Estrogen Receptor Expression in the Growth Plate Declines as Puberty ProgressesQ57247223
Effects of estrogen upon bile: implications with respect to gallstone formationQ67259454
P577publication date2020-02-29
P1433published inHepatologyQ15724398
P1476titleActivation of a novel estrogen receptor GPR30 enhances cholesterol cholelithogenesis in female mice

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