A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings

scientific article published on 26 February 2020

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings is …
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scholarly articleQ13442814

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P356DOI10.1016/J.JCMGH.2020.02.005
P932PMC publication ID7240226
P698PubMed publication ID32112828

P50authorKirill PeskovQ84712562
Gabriel HelmlingerQ87899082
Bo AngelinQ89178973
P2093author name stringChanchal Kumar
Mats Rudling
Victor Sokolov
Sara Straniero
Veronika Voronova
Amani Al-Khaifi
P2860cites workBile acids: natural ligands for an orphan nuclear receptorQ22010063
Bile acid transportersQ24652624
Recent advances in the understanding of bile acid malabsorptionQ28264279
The effect of cholecystectomy on bile salt metabolismQ28364050
Bile salt biotransformations by human intestinal bacteriaQ29622858
Short bowel syndrome: a nutritional and medical approach.Q33787695
Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisitedQ34146325
Bile salt transporters: molecular characterization, function, and regulationQ34186800
Variability of gastrointestinal transit in healthy women and men.Q34410247
The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid.Q34444158
Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjectsQ34471927
Enterohepatic circulation of bile acids after cholecystectomyQ34474514
Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestineQ34476471
Kinetics of bile acid metabolism in experimental blind loop syndromeQ34477367
Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunumQ34519450
Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte culturesQ34736335
Bile acid-mediated hepatocyte apoptosis and cholestatic liver diseaseQ34753740
A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesisQ34979989
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.Q35062300
Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy manQ35205903
Intestinal transport and metabolism of bile acidsQ35247159
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.Q35444103
Interactions between the intestinal microbiota and bile acids in gallstones patientsQ35684716
Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver DiseaseQ36023779
Determinants of post-prandial plasma bile acid kinetics in human volunteersQ36414100
Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serumQ36986629
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling moleculesQ36987335
The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in manQ37052975
Mechanism-Based Modeling of Gastric Emptying Rate and Gallbladder Emptying in Response to Caloric IntakeQ37540015
Hepatic FXR: key regulator of whole-body energy metabolismQ37921452
Bile salts and their importance for drug absorptionQ38099993
Bile acid receptors as targets for drug development.Q38132058
Bile Acid Uptake Transporters as Targets for Therapy.Q39156569
Colonic absorption of unconjugated bile acids: perfusion studies in manQ41679182
Serum concentrations of unconjugated and conjugated cholic acid in portal venous and systemic venous blood of fasting man.Q42198023
Effects of artificial depletion of the bile acid pool in man.Q43197952
Bile acid levels are increased in the liver of patients with steatohepatitisQ46604037
Individual serum bile acid concentrations in normo- and hyperlipoproteinemia as determined by mass fragmentography: relation to bile acid pool sizeQ47317813
Complex interaction between circadian rhythm and diet on bile acid homeostasis in male ratsQ48020702
Portal venous bile acids in cholesterol gallstone disease: effect of treatment with chenodeoxycholic and cholic acidsQ50181668
Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated.Q50660119
Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.Q51485180
Effects of fasting on bile acid metabolism and biliary lipid composition in manQ51671071
In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism.Q55333816
Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolismQ57113773
An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy VolunteersQ57117057
Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure-Activity Relationships and Rate-Limiting StepsQ57120132
Simulation of the metabolism and enterohepatic circulation of endogenous deoxycholic acid in humans using a physiologic pharmacokinetic model for bile acid metabolismQ69215026
Simulation of the metabolism and enterohepatic circulation of endogenous chenodeoxycholic acid in man using a physiological pharmacokinetic modelQ70321442
Regional distribution of solute carrier mRNA expression along the human intestinal tractQ79551075
Human cecal bile acids: concentration and spectrumQ80107957
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and healthQ83637970
P4510describes a project that usesggplot2Q326489
P577publication date2020-02-26
P1433published inCellular and molecular gastroenterology and hepatologyQ27726289
P1476titleA Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings

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