Chrysophanol improves memory ability of d-galactose and Aβ25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus

scientific article published on 13 February 2020

Chrysophanol improves memory ability of d-galactose and Aβ25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S13205-020-2103-Z
P932PMC publication ID7018885
P698PubMed publication ID32117672

P50authorBiao CaiQ88337145
P2093author name stringYan Wang
Peng Zhou
Shu Ye
Biao Cai
Xinquan Li
Junlong Ma
Huawu Gao
Rupeng Hua
P2860cites workCa(2+)/CaM-dependent kinases: from activation to functionQ28206372
Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's diseaseQ28387305
Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal miceQ34096005
Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Q35164866
Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microgliaQ35643566
Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal deathQ36069883
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signalingQ37065235
Tau phosphorylation: the therapeutic challenge for neurodegenerative diseaseQ37402114
Sex and the development of Alzheimer's disease.Q37432182
Axonal transport defects in neurodegenerative diseasesQ37614744
Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in MiceQ37721833
Analysis of CaM-kinase signaling in cellsQ37870268
Alzheimer's disease as oligomeropathyQ38618147
Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discoveryQ38962035
Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway.Q39817198
Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and SpinesQ42913207
Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fissionQ46336693
Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial FissionQ46345930
Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microgliaQ47107415
Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice.Q50421216
Chrysophanol ameliorates high-fat diet-induced obesity and inflammation in neonatal rats.Q51730794
Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease.Q52587490
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.Q53382756
Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathwaysQ57297194
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathwayQ61811004
Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic PotentialQ64245399
Protects d-Galactose/AlCl Mediated Alzheimer's Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their HippocampusQ64250215
RKIP-Mediated NF-κB Signaling is involved in ELF-MF-mediated improvement in AD rat.Q64972649
Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitabilityQ90673939
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategiesQ90836456
Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's DiseaseQ91093487
Antiapoptosis effect of ZiShen prescription to increase learning and memory abilities of compound Alzheimer's disease model ratsQ91798319
Protective Effects of Centella asiatica on Cognitive Deficits Induced by D-gal/AlCl₃ via Inhibition of Oxidative Stress and Attenuation of Acetylcholinesterase LevelQ92757758
PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's DiseaseQ93061615
P433issue3
P304page(s)111
P577publication date2020-02-13
P1433published in3 BiotechQ27723811
P1476titleChrysophanol improves memory ability of d-galactose and Aβ25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus
P478volume10

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