Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression

scientific article published on 10 September 2019

Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-019-1879-4
P932PMC publication ID6736983
P698PubMed publication ID31506436

P50authorGunnar PejlerQ90307224
P2093author name stringChristian P Sommerhoff
Fabio Rabelo Melo
Sebastin Santosh Martin
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
The structure of the human betaII-tryptase tetramer: fo(u)r better or worseQ24615069
Neutralizing tumor-promoting chronic inflammation: a magic bullet?Q26830931
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Human beta-tryptase is a ring-like tetramer with active sites facing a central poreQ27748987
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Serglycin: the master of the mast cellQ83263851
BMP6-induced modulation of the tumor micro-milieuQ91254645
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Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of active tryptase monomers in the presence of low molecular weight heparinQ28590282
Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infectionQ34263777
Mast cell secretory granules: armed for battleQ35182662
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesisQ35198652
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Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor GrowthQ36837385
Mast cell proteasesQ36942528
Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesisQ37138610
The roles of mast cells in anticancer immunityQ37256987
The controversial role of mast cells in tumor growthQ37505656
Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule proteaseQ37635812
Mast cell proteases: multifaceted regulators of inflammatory diseaseQ37710252
hnRNP A1: the Swiss army knife of gene expressionQ38142712
Mast cells as targets for immunotherapy of solid tumors.Q38201926
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Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancerQ38827252
Mast cells play a protumorigenic role in primary cutaneous lymphomaQ39307433
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.Q39790514
Increased level of circulating U2 small nuclear RNA fragments indicates metastasis in melanoma patientsQ41290936
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanomaQ41443221
The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lungQ42074207
Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression.Q42282866
Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosisQ42619165
Selected contribution: tryptase-induced PAR-2-mediated Ca(2+) signaling in human airway smooth muscle cellsQ43678665
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.Q44213212
Nafamostat mesilate is an extremely potent inhibitor of human tryptaseQ44562382
The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infectionsQ45134515
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumorsQ46273904
Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells.Q51177448
Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma.Q55030529
Mechanism for Activation of Mouse Mast Cell Tryptase: Dependence on Heparin and Acidic pH for Formation of Active Tetramers of Mouse Mast Cell Protease 6†Q60602793
Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species productionQ64054376
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2Q73382005
P433issue9
P921main subjectmast cellQ191989
P304page(s)659
P577publication date2019-09-10
P1433published inCell Death and DiseaseQ2197222
P1476titleExosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression
P478volume10

Reverse relations

Q90461487The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cellscites workP2860

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