Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation

scientific article published on 01 June 2019

Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.119.12832
P698PubMed publication ID31006330

P50authorKamal RahmouniQ57077889
Jiaxi XuQ88081680
P2093author name stringEric Lazartigues
Donald A Morgan
Andrea Zsombok
Snigdha Mukerjee
Adrien J R Molinas
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A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous SystemsQ28072451
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TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamateQ28575819
Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte developmentQ28591577
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Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertensionQ35776904
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Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.Q36917960
Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive miceQ37225431
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in miceQ37325289
Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failureQ37430939
AT2 receptor signaling and sympathetic regulationQ37821128
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Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.Q38781945
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A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communicationQ41344885
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TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptorsQ44734604
Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neuronsQ45244950
In vivo characterization of the angiotensin-(1-7)-induced dopamine and gamma-aminobutyric acid release in the striatum of the rat.Q46651527
Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive ratsQ48260358
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AT(1) and glutamatergic receptors in paraventricular nucleus support blood pressure during water deprivationQ48329753
Renin-angiotensin system modulates neurotransmitters in the paraventricular nucleus and contributes to angiotensin II-induced hypertensive responseQ48379915
Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in HypertensionQ48447355
Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic OutflowQ48489132
Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive ratsQ48541426
P433issue6
P304page(s)1266-1274
P577publication date2019-06-01
P1433published inHypertensionQ5958695
P1476titleActivation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation
P478volume73

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cites work (P2860)
Q90349742ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons
Q98224393Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension